PMID- 30604578 OWN - NLM STAT- MEDLINE DCOM- 20200303 LR - 20200303 IS - 2042-6984 (Electronic) IS - 2042-6976 (Linking) VI - 9 IP - 5 DP - 2019 May TI - Atopy in chronic rhinosinusitis: impact on quality of life outcomes. PG - 501-507 LID - 10.1002/alr.22272 [doi] AB - BACKGROUND: Chronic rhinosinusitis (CRS), in particular with nasal polyps (CRSwNP), has been linked with skewed T-helper 2 and immunoglobulin E (IgE)-mediated allergic responses. The role of atopy in CRS, however, remains unclear. Correlations between immunological allergic markers and patient-reported outcomes measures (PROMs) were investigated. METHODS: A cross-sectional study of adult patients with CRS undergoing endoscopic sinus surgery was conducted. Immunological allergic markers included automated immunoassay testing for serum-specific IgE to common allergens (house dust mite, grass, mold, animal epithelia) and total IgE. PROMs were assessed using the 22-item Sino-Nasal Outcome Test (SNOT-22). Patients were defined as atopic based on either a positive specific IgE or elevated total IgE (>160 kU/L). RESULTS: A total of 446 patients (45.7% female, age 49.05 +/- 14.96 years) were recruited, of which 42.8% had asthma, 51.6% had CRSwNP, and 63.0% had eosinophilic CRS. Positive allergen sensitization was detected in 52.9% patients. Total IgE levels were elevated in 28.0% with mean IgE level of 161 +/- 269 kU/L. Atopy was associated with younger age at the time of surgery, CRSwNP, asthma, and eosinophilic CRS (eCRS). Atopy was also associated with increased severity in nasal symptom score (13.1 +/- 6.4 vs 11.9 +/- 6.0, p = 0.04), as well as worse scores in the loss of smell/taste (chi(2) (1) = 5.97, p = 0.02) and need to blow nose (chi(2) (1) = 4.26, p = 0.04) questions in the CRS population. In the CRSwNP population, there was no significant association between atopy and PROMs. CONCLUSION: Comorbid atopy in CRS is associated with additional symptom burden, reflected mainly within the nasal symptom quality of life markers. Atopy assessment in CRS is important to ensure appropriate and successful treatment of the disease. CI - (c) 2018 ARS-AAOA, LLC. FAU - Ho, Jacqueline AU - Ho J AUID- ORCID: 0000-0002-2765-8684 AD - Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia. AD - St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. FAU - Alvarado, Raquel AU - Alvarado R AD - Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia. FAU - Rimmer, Janet AU - Rimmer J AD - Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia. AD - Woolcock Institute, University of Sydney, Sydney, Australia. AD - Faculty of Medicine, Notre Dame University, Sydney, Australia. FAU - Sewell, William A AU - Sewell WA AD - St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. AD - Immunology Division, Garvan Institute of Medical Research, Sydney, Australia. FAU - Harvey, Richard J AU - Harvey RJ AD - Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia. AD - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia. LA - eng PT - Journal Article DEP - 20190103 PL - United States TA - Int Forum Allergy Rhinol JT - International forum of allergy & rhinology JID - 101550261 RN - 0 (Allergens) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adult MH - Allergens/immunology MH - Chronic Disease MH - Endoscopy MH - Female MH - Humans MH - Hypersensitivity, Immediate/blood/*epidemiology/immunology/surgery MH - Immunoglobulin E/blood/immunology MH - Male MH - Middle Aged MH - Nasal Polyps/blood/*epidemiology/immunology/surgery MH - Nasal Surgical Procedures MH - Quality of Life MH - Rhinitis/blood/*epidemiology/immunology/surgery MH - Severity of Illness Index MH - Sino-Nasal Outcome Test MH - Sinusitis/blood/*epidemiology/immunology/surgery OTO - NOTNLM OT - ImmunoCAP OT - allergy OT - atopy OT - chronic rhinosinusitis OT - immunoglobulin E OT - nasal polyps OT - patient-reported outcome measures OT - quality of life EDAT- 2019/01/04 06:00 MHDA- 2020/03/04 06:00 CRDT- 2019/01/04 06:00 PHST- 2018/09/05 00:00 [received] PHST- 2018/11/08 00:00 [revised] PHST- 2018/11/29 00:00 [accepted] PHST- 2019/01/04 06:00 [pubmed] PHST- 2020/03/04 06:00 [medline] PHST- 2019/01/04 06:00 [entrez] AID - 10.1002/alr.22272 [doi] PST - ppublish SO - Int Forum Allergy Rhinol. 2019 May;9(5):501-507. doi: 10.1002/alr.22272. Epub 2019 Jan 3.