PMID- 30604659
OWN - NLM
STAT- MEDLINE
DCOM- 20200819
LR  - 20200819
IS  - 1092-8529 (Print)
IS  - 1092-8529 (Linking)
VI  - 24
IP  - 4
DP  - 2019 Aug
TI  - Increased risk of type 2 diabetes among the siblings of patients with 
      schizophrenia.
PG  - 453-459
LID - 10.1017/S1092852918001396 [doi]
AB  - BACKGROUND: Research suggests an association between metabolic disorders, such as 
      type 2 diabetes mellitus (T2DM), and schizophrenia. However, the risk of 
      metabolic disorders in the unaffected siblings of patients with schizophrenia 
      remains unclear. METHODS: Using the Taiwan National Health Insurance Research 
      Database, 3135 unaffected siblings of schizophrenia probands and 12,540 
      age-/sex-matched control subjects were included and followed up to the end of 
      2011. Individuals who developed metabolic disorders during the follow-up period 
      were identified. RESULTS: The unaffected siblings of schizophrenia probands had a 
      higher prevalence of T2DM (3.4% vs. 2.6%, p = 0.010) than the controls. Logistic 
      regression analyses with the adjustment of demographic data revealed that the 
      unaffected siblings of patients with schizophrenia were more likely to develop 
      T2DM (odds ratio [OR]: 1.39, 95% confidence interval [CI]: 1.10-1.75) later in 
      life compared with the control group. Moreover, only female siblings of 
      schizophrenia probands had an increased risk of hypertension (OR: 1.47, 95% CI: 
      1.07-2.01) during the follow-up compared with the controls.DiscussionThe 
      unaffected siblings, especially sisters, of schizophrenia probands had a higher 
      prevalence of T2DM and hypertension compared with the controls. Our study 
      revealed a familial link between schizophrenia and T2DM in a large sample. 
      Additional studies are required to investigate the shared pathophysiology of 
      schizophrenia and T2DM.
FAU - Huang, Mao-Hsuan
AU  - Huang MH
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Chen, Mu-Hong
AU  - Chen MH
AUID- ORCID: 0000-0001-6516-1073
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Huang, Kai-Lin
AU  - Huang KL
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Hsu, Ju-Wei
AU  - Hsu JW
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Bai, Ya-Mei
AU  - Bai YM
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Cheng, Chih-Ming
AU  - Cheng CM
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Su, Tung-Ping
AU  - Su TP
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Li, Cheng-Ta
AU  - Li CT
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Lin, Wei-Chen
AU  - Lin WC
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Yang, Albert C
AU  - Yang AC
AD  - Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
FAU - Chen, Tzeng-Ji
AU  - Chen TJ
AD  - Department of Family Medicine,Taipei Veterans General Hospital,Taipei,Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190103
PL  - United States
TA  - CNS Spectr
JT  - CNS spectrums
JID - 9702877
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/*epidemiology/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Schizophrenia/*epidemiology/genetics
MH  - *Siblings
OTO - NOTNLM
OT  - Epidemiology
OT  - metabolic disorders
OT  - schizophrenia
OT  - siblings
OT  - type 2 diabetes mellitus
EDAT- 2019/01/04 06:00
MHDA- 2020/08/20 06:00
CRDT- 2019/01/04 06:00
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2020/08/20 06:00 [medline]
PHST- 2019/01/04 06:00 [entrez]
AID - S1092852918001396 [pii]
AID - 10.1017/S1092852918001396 [doi]
PST - ppublish
SO  - CNS Spectr. 2019 Aug;24(4):453-459. doi: 10.1017/S1092852918001396. Epub 2019 Jan 
      3.