PMID- 30604666
OWN - NLM
STAT- MEDLINE
DCOM- 20190130
LR  - 20190226
IS  - 1522-6662 (Electronic)
IS  - 1098-3511 (Linking)
VI  - 21
IP  - 6
DP  - 2018 Nov 7
TI  - Surgical Treatment for Hypertrophic Obstructive Cardiomyopathy with Concomitant 
      Mitral Valve Abnormalities: A Cohort of 26 Cases.
PG  - E443-E447
LID - 10.1532/hsf.2013 [doi]
AB  - BACKGROUND: We sought to analyze the pathological characteristics of hypertrophic 
      obstructive cardiomyopathy (HOCM) with concomitant mitral valve abnormalities and 
      to discuss the surgical treatment strategies. METHODS: The clinical data of 26 
      HOCM patients treated from January 2014 to March 2016 were retrospectively 
      analyzed. There were 19 males and 7 females with a mean age of 47 +/- 16 years 
      (range, 10-70 years). Echocardiography showed HOCM, systolic anterior motion of 
      the mitral apparatus, and concomitant mitral regurgitation. Modified Morrow 
      procedure with expanded resection area was performed in 21 patients. Concomitant 
      mitral valvuloplasty was performed in 4 patients, coronary artery bypass grafting 
      was performed in one patient, and aortic valve replacement was performed in one 
      patient. Echocardiography was performed intraoperatively at postoperative 1 week 
      and at postoperative 1 year to evaluate the left ventricular obstruction and the 
      mitral regurgitation. RESULTS: The left ventricular outflow tract gradient, left 
      ventricular outflow tract velocity, septal thickness, and mitral regurgitation 
      area decreased significantly at postoperative 1 week and 1 year in comparison 
      with the baseline (all P < .001). The postoperative mitral regurgitation and 
      systolic anterior motion of the mitral apparatus were completely abolished or 
      significantly relieved. Only one patient had moderate mitral regurgitation of 7 
      cm2 after the surgery. At postoperative 1 year, all patients were asymptomatic, 
      and the quality of life was significantly improved. The New York Heart 
      Association (NYHA) class was I-II. Echocardiography showed good anatomy and 
      function of the mitral valve. CONCLUSIONS: Concomitant mitral valve abnormality 
      is not uncommon in HOCM. Septal myectomy can adequately expand the left 
      ventricular outflow tract and abolish mitral regurgitation and systolic anterior 
      motion of the mitral apparatus. Concomitant mitral valvuloplasty is indicated for 
      severe congenital abnormalities or secondary lesions of the mitral valve, and the 
      outcomes are satisfactory.
FAU - Song, Bang-Rong
AU  - Song BR
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
FAU - Ren, Yanlong
AU  - Ren Y
AD  - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, China.
FAU - Zhang, Hong-Jia
AU  - Zhang HJ
AD  - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
LA  - eng
PT  - Journal Article
DEP - 20181107
PL  - United States
TA  - Heart Surg Forum
JT  - The heart surgery forum
JID - 100891112
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiac Surgical Procedures/methods
MH  - Cardiomyopathy, Hypertrophic/*complications/diagnostic imaging/pathology/*surgery
MH  - Child
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/diagnostic imaging/physiopathology/surgery
MH  - Mitral Valve Insufficiency/*complications/diagnostic 
      imaging/physiopathology/*surgery
MH  - Retrospective Studies
MH  - Ultrasonography, Doppler
MH  - Young Adult
EDAT- 2019/01/04 06:00
MHDA- 2019/01/31 06:00
CRDT- 2019/01/04 06:00
PHST- 2018/03/30 00:00 [received]
PHST- 2018/09/28 00:00 [accepted]
PHST- 2019/01/04 06:00 [entrez]
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2019/01/31 06:00 [medline]
AID - 10.1532/hsf.2013 [doi]
PST - epublish
SO  - Heart Surg Forum. 2018 Nov 7;21(6):E443-E447. doi: 10.1532/hsf.2013.