PMID- 30605362
OWN - NLM
STAT- MEDLINE
DCOM- 20200130
LR  - 20200130
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 96
IP  - 1
DP  - 2020 Jan
TI  - Development of a biodosimeter for radiation triage using novel blood protein 
      biomarker panels in humans and non-human primates.
PG  - 22-34
LID - 10.1080/09553002.2018.1532611 [doi]
AB  - Purpose: In a significant nuclear event, hundreds of thousands of individuals 
      will require rapid triage for absorbed radiation to ensure effective medical 
      treatment and efficient use of medical resources. We are developing a rapid 
      screening method to assess whether an individual received an absorbed dose of 
      >/=2 Gy based on the analysis of a specific panel of blood proteins in a 
      fingerstick blood sample.Materials and methods: We studied a data set of 1051 
      human blood samples obtained from radiotherapy patients, normal healthy 
      individuals, and several special population groups. We compared the findings in 
      humans with those from irradiation studies in non-human primates (NHPs).Results: 
      We identified a panel of three protein biomarkers, salivary alpha amylase (AMY1), 
      Flt3 ligand (FLT3L), and monocyte chemotactic protein 1 (MCP1), which are 
      upregulated in human patients receiving fractionated doses of total body 
      irradiation (TBI) therapy as a treatment for cancer. These proteins exhibited a 
      similar radiation response in NHPs after single acute or fractionated doses of 
      ionizing radiation.Conclusion: Our work provides confidence in this biomarker 
      panel for biodosimetry triage using fingerstick blood samples and in the use of 
      NHPs as a model for irradiated humans.
FAU - Balog, Robert P
AU  - Balog RP
AD  - SRI International, Menlo Park, CA, USA.
FAU - Bacher, Rowena
AU  - Bacher R
AD  - SRI International, Menlo Park, CA, USA.
FAU - Chang, Polly
AU  - Chang P
AD  - SRI International, Menlo Park, CA, USA.
FAU - Greenstein, Michael
AU  - Greenstein M
AD  - SRI International, Menlo Park, CA, USA.
FAU - Jammalamadaka, Songeeta
AU  - Jammalamadaka S
AD  - SRI International, Menlo Park, CA, USA.
FAU - Javitz, Harold
AU  - Javitz H
AD  - SRI International, Menlo Park, CA, USA.
FAU - Knox, Susan J
AU  - Knox SJ
AD  - Department of Radiation Oncology, Stanford University, Stanford, CA, USA.
FAU - Lee, Shirley
AU  - Lee S
AD  - SRI International, Menlo Park, CA, USA.
FAU - Lin, Hua
AU  - Lin H
AD  - SRI International, Menlo Park, CA, USA.
FAU - Shaler, Thomas
AU  - Shaler T
AD  - SRI International, Menlo Park, CA, USA.
FAU - Shura, Lei
AU  - Shura L
AD  - Department of Radiation Oncology, Stanford University, Stanford, CA, USA.
FAU - Stein, Paul
AU  - Stein P
AD  - SRI International, Menlo Park, CA, USA.
FAU - Todd, Kathryn
AU  - Todd K
AD  - SRI International, Menlo Park, CA, USA.
FAU - Cooper, David E
AU  - Cooper DE
AD  - SRI International, Menlo Park, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190103
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Biomarkers)
RN  - 0 (Blood Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Biomarkers/blood
MH  - Blood Proteins/*analysis
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunoassay
MH  - Macaca mulatta
MH  - Male
MH  - Middle Aged
MH  - Radiometry/*methods
MH  - Triage/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - Radiation biodosimetry
OT  - blood biomarkers
OT  - human radiotherapy patient studies
OT  - immunoassays
OT  - point of care test
EDAT- 2019/01/04 06:00
MHDA- 2020/01/31 06:00
CRDT- 2019/01/04 06:00
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2020/01/31 06:00 [medline]
PHST- 2019/01/04 06:00 [entrez]
AID - 10.1080/09553002.2018.1532611 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2020 Jan;96(1):22-34. doi: 10.1080/09553002.2018.1532611. Epub 
      2019 Jan 3.