PMID- 30605399
OWN - NLM
STAT- MEDLINE
DCOM- 20200617
LR  - 20200617
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 126
IP  - 3
DP  - 2019 Mar 1
TI  - Exercise-induced hyperemia is associated with knee extensor fatigability in 
      adults with type 2 diabetes.
PG  - 658-667
LID - 10.1152/japplphysiol.00854.2018 [doi]
AB  - The aim of this study was to compare fatigability, contractile function, and 
      blood flow to the knee extensor muscles after dynamic exercise in patients with 
      type 2 diabetes mellitus (T2DM) and controls. The hypotheses were that patients 
      with T2DM would demonstrate greater fatigability than controls, and greater 
      fatigability would be associated with a lower exercise-induced increase in blood 
      flow and greater impairments in contractile function. Patients with T2DM ( n = 
      15; 8 men; 62.4 +/- 9.0 yr; 30.4 +/- 7.7 kg/m(2); 7,144 +/- 3,294 steps/day) and 15 
      healthy control subjects (8 men, 58.4 +/- 6.9 yr; 28.4 +/- 4.6 kg/m(2); 7,893 +/- 2,323 
      steps/day) were matched for age, sex, body mass index, and physical activity. 
      Fatigability was quantified as the reduction in knee extensor power during a 
      6-min dynamic exercise. Before and after exercise, vascular ultrasonography and 
      electrical stimulation were used to assess skeletal muscle blood flow and 
      contractile properties, respectively. Patients with T2DM had greater fatigability 
      (30.0 +/- 20.1% vs. 14.6 +/- 19.0%, P < 0.001) and lower exercise-induced hyperemia 
      (177 +/- 90% vs. 194 +/- 79%, P = 0.04) than controls but similar reductions in the 
      electrically evoked twitch amplitude (37.6 +/- 24.8% vs. 31.6 +/- 30.1%, P = 0.98). 
      Greater fatigability of the knee extensor muscles was associated with 
      postexercise reductions in twitch amplitude ( r = 0.64, P = 0.001) and lesser 
      exercise-induced hyperemia ( r = -0.56, P = 0.009). Patients with T2DM had 
      greater lower-limb fatigability during dynamic exercise, which was associated 
      with reduced contractile function and lower skeletal muscle blood flow. Thus, 
      treatments focused on enhancing perfusion and reversing impairments in 
      contractile function in patients with T2DM may offset lower-limb fatigability and 
      aid in increasing exercise capacity. NEW & NOTEWORTHY Although prior studies 
      compare patients with type 2 diabetes mellitus (T2DM) with lean controls, our 
      study includes controls matched for age, body mass, and physical activity to more 
      closely assess the effects of T2DM. Patients with T2DM demonstrated no impairment 
      in macrovascular endothelial function, evidenced by similar flow-mediated 
      dilation to controls. However, patients with T2DM had greater fatigability and 
      reduced exercise-induced increase in blood flow (hyperemia) after a lower-limb 
      dynamic fatiguing exercise compared with controls.
FAU - Senefeld, Jonathon W
AU  - Senefeld JW
AUID- ORCID: 0000-0001-8116-3538
AD  - Clinical and Translational Rehabilitation Health Sciences Program, Marquette 
      University , Milwaukee, Wisconsin.
AD  - Department of Physical Therapy, Marquette University , Milwaukee, Wisconsin.
FAU - Limberg, Jacqueline K
AU  - Limberg JK
AD  - Department of Nutrition and Exercise Physiology, University of Missouri , 
      Columbia, Missouri.
FAU - Lukaszewicz, Kathleen M
AU  - Lukaszewicz KM
AD  - Clinical and Translational Rehabilitation Health Sciences Program, Marquette 
      University , Milwaukee, Wisconsin.
AD  - Department of Physical Therapy, Marquette University , Milwaukee, Wisconsin.
FAU - Hunter, Sandra K
AU  - Hunter SK
AUID- ORCID: 0000-0001-8013-2051
AD  - Clinical and Translational Rehabilitation Health Sciences Program, Marquette 
      University , Milwaukee, Wisconsin.
AD  - Department of Physical Therapy, Marquette University , Milwaukee, Wisconsin.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190103
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Electric Stimulation/methods
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Hyperemia/*physiopathology
MH  - Isometric Contraction/physiology
MH  - Knee/*physiopathology
MH  - Knee Joint/physiopathology
MH  - Lower Extremity/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction/physiology
MH  - Muscle Fatigue/*physiology
MH  - Muscle, Skeletal/physiopathology
MH  - Regional Blood Flow/physiology
OTO - NOTNLM
OT  - blood flow
OT  - diabetes
OT  - fatigue
OT  - reactive hyperemia
OT  - skeletal muscle
EDAT- 2019/01/04 06:00
MHDA- 2020/06/18 06:00
CRDT- 2019/01/04 06:00
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2020/06/18 06:00 [medline]
PHST- 2019/01/04 06:00 [entrez]
AID - 10.1152/japplphysiol.00854.2018 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2019 Mar 1;126(3):658-667. doi: 
      10.1152/japplphysiol.00854.2018. Epub 2019 Jan 3.