PMID- 30605424
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20190415
IS  - 1105-2333 (Print)
IS  - 1105-2333 (Linking)
VI  - 29
IP  - 3
DP  - 2018 Jul-Sep
TI  - Hypothalamus-pituitary-adrenal (HPA) axis parameters and neurocognitive 
      evaluation in patients with bipolar disorder.
PG  - 199-208
LID - 10.22365/jpsych.2018.293.199 [doi]
AB  - Bipolar disorder is associated with neurocognitive impairment but the etiology of 
      such impairment remains largely unknown. The present study aimed at investigating 
      the performance of bipolar patients in various neuropsychological tasks within 
      the framework of HPA axis hyperactivity model and also the impact of disease 
      characteristics on neuropsychological functioning. Cognitive performance of 60 
      bipolar-I patients and 30 healthy controls was evaluated by using tasks from the 
      CANTAB battery targeting visual memory, executive function and inhibitory 
      control. Current symptoms were evaluated via administration of the Hamilton 
      Depression Rating Scale (HAMD) and Young Mania Rating Scale (YMRS) whereas 
      assessment of functioning was performed with the Global Assessment of Functioning 
      (GAF). Basal cortisol levels were determined and all patients were administered 
      the Dexamethasone Suppression Test (DST). Statistically significant differences 
      between patients and controls were found in visuo-spatial associative learning 
      and memory, planning, attentional set shifting and inhibitory control. Worse 
      performance in visuospatial associative memory correlated with longer duration of 
      illness and higher levels of basal cortisol. Poorer attentional set shifting was 
      related to higher number of manic episodes. We found no relationship of 
      neurocognitive measures with DST suppression status, current symptom severity or 
      history of psychosis. The results of our study confirm the presence of cognitive 
      deficits in bipolar disorder and provide evidence on the relation of cortisol 
      with neuropsychological functioning, especially visuo-spatial associative memory. 
      Moreover, we have found that number of previous manic episodes and duration of 
      illness is associated with worse cognitive performance. It is known that 
      neurocognitive deficits are evident in many patients with bipolar disorder. These 
      deficits are often a cause of considerable distress and can lead to impairment of 
      psychosocial and occupational functioning. The role of HPA axis needs to be 
      further examined in bipolar disorder. Nevertheless, the identification of factors 
      affecting neurocognitive functioning, like basal cortisol and number of manic 
      episodes, may contribute to the implementation of more appropriate prevention 
      strategies.
FAU - Tournikioti, K
AU  - Tournikioti K
AD  - Second Department of Psychiatry, Attikon General Hospital, University of Athens, 
      Medical School, Athens.
FAU - Dikeos, D
AU  - Dikeos D
AD  - First Department of Psychiatry, Eginition Hospital, University of Athens, Medical 
      School, Athens.
FAU - Alevizaki, M
AU  - Alevizaki M
AD  - Endocrine Unit, Department of Medical Therapeutics, Alexandra Hospital, 
      University of Athens, Medical School, Athens.
FAU - Michopoulos, I
AU  - Michopoulos I
AD  - Second Department of Psychiatry, Attikon General Hospital, University of Athens, 
      Medical School, Athens.
FAU - Ferentinos, P
AU  - Ferentinos P
AD  - Second Department of Psychiatry, Attikon General Hospital, University of Athens, 
      Medical School, Athens.
FAU - Porichi, E
AU  - Porichi E
AD  - Second Department of Psychiatry, Attikon General Hospital, University of Athens, 
      Medical School, Athens.
FAU - Soldatos, C R
AU  - Soldatos CR
AD  - Mental Health Care Unit, Evgenidion Hospital, University of Athens, Medical 
      School, Athens, Greece.
FAU - Douzenis, A
AU  - Douzenis A
AD  - Second Department of Psychiatry, Attikon General Hospital, University of Athens, 
      Medical School, Athens.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Psychiatriki
JT  - Psychiatrike = Psychiatriki
JID - 101534363
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*physiopathology/*psychology
MH  - Cognitive Dysfunction/etiology/psychology
MH  - Executive Function
MH  - Female
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Neuropsychological Tests
MH  - Pituitary-Adrenal System/*physiopathology
MH  - Spatial Memory
EDAT- 2019/01/04 06:00
MHDA- 2019/04/16 06:00
CRDT- 2019/01/04 06:00
PHST- 2019/01/04 06:00 [entrez]
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
AID - 10.22365/jpsych.2018.293.199 [doi]
PST - ppublish
SO  - Psychiatriki. 2018 Jul-Sep;29(3):199-208. doi: 10.22365/jpsych.2018.293.199.