PMID- 30605622
OWN - NLM
STAT- MEDLINE
DCOM- 20200122
LR  - 20231005
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 108
DP  - 2019 Feb
TI  - Site-specific effects of aromatase inhibition on the activation of male sexual 
      behavior in male Japanese quail (Coturnix japonica).
PG  - 42-49
LID - S0018-506X(18)30404-5 [pii]
LID - 10.1016/j.yhbeh.2018.12.015 [doi]
AB  - Aromatization within the medial preoptic nucleus (POM) is essential for the 
      expression of male copulatory behavior in Japanese quail. However, several nuclei 
      within the social behavior network (SBN) also express aromatase. Whether 
      aromatase in these loci participates in the behavioral activation is not known. 
      Castrated male Japanese quail were implanted with 2 subcutaneous Silastic 
      capsules filled with crystalline testosterone and with bilateral stereotaxic 
      implants filled with the aromatase inhibitor Vorozole targeting the POM, the bed 
      nucleus of the stria terminalis (BST) or the ventromedial nucleus of the 
      hypothalamus (VMN). Control animals were implanted with testosterone and empty 
      bilateral stereotaxic implants. Starting 2 days after the surgery, subjects were 
      tested for the expression of consummatory sexual behavior (CSB) every other day 
      for a total of 10 tests. They were also tested once for appetitive sexual 
      behavior (ASB) as measured by the rhythmic cloacal sphincter movements displayed 
      in response to the visual presentation of a female. CSB was drastically reduced 
      when the Vorozole implants were localized in the POM, but not in the BST nor in 
      the VMN. Birds with implants in the BST took longer to show CSB in the first 6 
      tests than controls, suggesting a role of the BST in the acquisition of the full 
      copulatory ability. ASB was not significantly affected by aromatase blockade in 
      any region. These data confirm the key role played by the POM in the control of 
      male sexual behavior and suggest a minor role for aromatization in the BST or 
      VMN.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - de Bournonville, Marie-Pierre
AU  - de Bournonville MP
AD  - GIGA Neurosciences, University of Liege, Belgium.
FAU - Vandries, Laura M
AU  - Vandries LM
AD  - GIGA Neurosciences, University of Liege, Belgium.
FAU - Ball, Gregory F
AU  - Ball GF
AD  - Department of Psychology, University of Maryland, College Park, MD, United States 
      of America.
FAU - Balthazart, Jacques
AU  - Balthazart J
AD  - GIGA Neurosciences, University of Liege, Belgium.
FAU - Cornil, Charlotte A
AU  - Cornil CA
AD  - GIGA Neurosciences, University of Liege, Belgium. Electronic address: 
      charlotte.cornil@uliege.be.
LA  - eng
GR  - R01 MH050388/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190109
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Aromatase Inhibitors)
RN  - 0 (Triazoles)
RN  - 1E2S9YXV2A (vorozole)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Animals
MH  - Appetitive Behavior/drug effects
MH  - Aromatase/*metabolism
MH  - Aromatase Inhibitors/*pharmacology
MH  - Brain Mapping/methods/veterinary
MH  - Consummatory Behavior/drug effects
MH  - Coturnix/*physiology
MH  - Female
MH  - Male
MH  - Organ Specificity/drug effects
MH  - Preoptic Area/drug effects/metabolism
MH  - Septal Nuclei/drug effects/metabolism
MH  - Sex Factors
MH  - Sexual Behavior, Animal/*drug effects/physiology
MH  - Testosterone/pharmacology
MH  - Triazoles/*pharmacology
MH  - Ventromedial Hypothalamic Nucleus/drug effects/metabolism
PMC - PMC6377315
MID - NIHMS1518344
OTO - NOTNLM
OT  - Bed nucleus of the stria terminalis
OT  - Bird
OT  - Consummatory sexual behavior
OT  - Medial preoptic area
OT  - Neuroestrogens
EDAT- 2019/01/04 06:00
MHDA- 2020/01/23 06:00
PMCR- 2020/02/01
CRDT- 2019/01/04 06:00
PHST- 2018/09/13 00:00 [received]
PHST- 2018/12/21 00:00 [revised]
PHST- 2018/12/30 00:00 [accepted]
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2020/01/23 06:00 [medline]
PHST- 2019/01/04 06:00 [entrez]
PHST- 2020/02/01 00:00 [pmc-release]
AID - S0018-506X(18)30404-5 [pii]
AID - 10.1016/j.yhbeh.2018.12.015 [doi]
PST - ppublish
SO  - Horm Behav. 2019 Feb;108:42-49. doi: 10.1016/j.yhbeh.2018.12.015. Epub 2019 Jan 
      9.