PMID- 30605646
OWN - NLM
STAT- MEDLINE
DCOM- 20190301
LR  - 20190301
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 218
DP  - 2019 Feb 1
TI  - Proton pump inhibitors therapy and risk of bone diseases: An update 
      meta-analysis.
PG  - 213-223
LID - S0024-3205(18)30859-2 [pii]
LID - 10.1016/j.lfs.2018.12.058 [doi]
AB  - AIMS: Large observational studies have yielded conflicting results regarding 
      whether the use of proton pump inhibitors (PPI) increases the risk of bone 
      diseases. Here, we performed a meta-analysis to examine the link between PPI and 
      risk of bone fractures, osteoporosis and bone mineral density (BMD) loss. 
      MATERIALS AND METHODS: We systematically performed a search for published reports 
      on PubMed, EMBASE and the Cochrane Library. We considered articles published in 
      English, and restricted the search to studies on human participants. Studies that 
      reported adjusted Hazard ratio (HR) estimates with 95% confidence intervals (CI) 
      for the associations of interest were included. Data from the articles which can 
      be used to estimate standardized mean difference (SMD) were also obtained and 
      utilized to assess the risk of BMD loss. KEY FINDINGS: Compared with patients not 
      taking PPI, those taking PPI, had the increased risk of developing any-site 
      fractures (HR: 1.30; 95%CI: 1.16 to 1.45), hip fracture (HR:1.22; 95%CI:1.15 to 
      1.31), spine fracture (HR:1.49; 95%CI:1.31 to 1.68), and osteoporosis (HR:1.23; 
      95%CI:1.06 to 1.42) based on a random model, but there was no correlation with 
      developing BMD loss in the femoral (SMD: -0.27; 95%CI: -0.62 to 0.09), or in the 
      spine (SMD: -0.06; 95%CI: -0.54 to 0.41). SIGNIFICANCE: Results of this 
      meta-analysis suggest that PPI may moderately increase the risk of any-site, hip, 
      spine fracture. Due to the widespread use of PPI and the impact of fractures on 
      human health, clinicians should carefully evaluate the patient condition before 
      prescribing PPI therapy.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Liu, Jian
AU  - Liu J
AD  - Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Li, Xianqing
AU  - Li X
AD  - Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Fan, Lei
AU  - Fan L
AD  - Department of Urology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Yang, Jie
AU  - Yang J
AD  - Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Wang, Jiecong
AU  - Wang J
AD  - Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Sun, Jiaming
AU  - Sun J
AD  - Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China. Electronic address: 
      sunjm1592@sina.com.
FAU - Wang, Zhenxing
AU  - Wang Z
AD  - Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China. Electronic address: 
      benjamin.wzx@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20181231
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Bone Diseases/*etiology
MH  - Humans
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Risk Factors
OTO - NOTNLM
OT  - Bone mineral density
OT  - Fracture
OT  - Meta-analysis
OT  - Osteoporosis
OT  - Proton pump inhibitors
EDAT- 2019/01/04 06:00
MHDA- 2019/03/02 06:00
CRDT- 2019/01/04 06:00
PHST- 2018/10/28 00:00 [received]
PHST- 2018/12/12 00:00 [revised]
PHST- 2018/12/29 00:00 [accepted]
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2019/03/02 06:00 [medline]
PHST- 2019/01/04 06:00 [entrez]
AID - S0024-3205(18)30859-2 [pii]
AID - 10.1016/j.lfs.2018.12.058 [doi]
PST - ppublish
SO  - Life Sci. 2019 Feb 1;218:213-223. doi: 10.1016/j.lfs.2018.12.058. Epub 2018 Dec 
      31.