PMID- 30605876
OWN - NLM
STAT- MEDLINE
DCOM- 20190411
LR  - 20210831
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 246
DP  - 2019 Mar 1
TI  - Predictors of longitudinal psychosocial functioning in bipolar youth 
      transitioning to adults.
PG  - 578-585
LID - S0165-0327(18)31936-0 [pii]
LID - 10.1016/j.jad.2018.12.108 [doi]
AB  - OBJECTIVES: In a sample of participants diagnosed with Bipolar Disorder (BD) in 
      youth, we aim: (1) to examine longitudinal psychosocial functioning; (2) to 
      determine whether psychosocial impairment remains in those who remitted from mood 
      disorders during later periods of follow-up; (3) to examine predictors of 
      psychosocial impairment despite symptomatic remission. METHOD: A Course and 
      Outcome of Bipolar Youth subsample of 367 (>/= 4 years follow-up data) were grouped 
      into mood trajectories: Class 1 Predominantly Euthymic; Class 2 Moderately 
      Euthymic; Class 3 Ill with Improving Course; Class 4 Predominantly Ill. 
      Psychosocial functioning was assessed via Children's Global Assessment Scale 
      (C-GAS) for those under age 22; Global Assessment of Functioning (GAF) scale 
      after 22. Current school, employment, and disability status were examined. 
      Established predictors of symptomatic impairment were analyzed. RESULTS: The 
      Predominantly Euthymic Class had better psychosocial functioning, and were more 
      likely to be in school/employed. The Persistently Ill Class had worse 
      psychosocial functioning, and were more likely to receive disability. However, 
      44% of Predominantly Euthymic and 93% of Ill with Improving Course participants 
      continued to experience current psychosocial impairment. Early BD onset, low 
      Socioeconomic Status (SES), and current comorbidity, predicted poor psychosocial 
      functioning. Low SES, and current comorbidity, predicted no school 
      enrollment/unemployment. LIMITATIONS: The study does not have a healthy control 
      group to compare functioning findings. CONCLUSIONS: In general, youth with 
      persistent mood symptoms had worse psychosocial functioning, moreover, those with 
      remitted symptoms still exhibited current psychosocial functioning deficits. High 
      risk individuals with predictors of impairment should be targeted for functioning 
      interventions.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hower, Heather
AU  - Hower H
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA; Department of Health Services, 
      Policy, and Practice, Brown University School of Public Health, 121 South Main 
      Street, Providence, RI 02903, USA.
FAU - Lee, Erica J
AU  - Lee EJ
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA; Butler Hospital, 700 Butler 
      Drive, Providence, RI 02906, USA.
FAU - Jones, Richard N
AU  - Jones RN
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA.
FAU - Birmaher, Boris
AU  - Birmaher B
AD  - Department of Psychiatry, Western Psychiatric Institute and Clinic, University of 
      Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Strober, Michael
AU  - Strober M
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California at Los Angeles, 760 Westwood Plaza, Mail Code 
      175919, Los Angeles, CA 90095, USA.
FAU - Goldstein, Benjamin I
AU  - Goldstein BI
AD  - Department of Psychiatry, Sunnybrook Health Sciences Centre, University of 
      Toronto Faculty of Medicine, 2075 Bayview Ave., FG-53, Toronto, ON M4N-3M5, 
      Canada.
FAU - Merranko, John
AU  - Merranko J
AD  - Department of Psychiatry, Western Psychiatric Institute and Clinic, University of 
      Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Keller, Martin B
AU  - Keller MB
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA; Bradley Hospital, 1011 Veterans 
      Memorial Parkway, East Providence, RI 02915, USA.
FAU - Goldstein, Tina R
AU  - Goldstein TR
AD  - Department of Psychiatry, Western Psychiatric Institute and Clinic, University of 
      Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Weinstock, Lauren M
AU  - Weinstock LM
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA; Butler Hospital, 700 Butler 
      Drive, Providence, RI 02906, USA.
FAU - Dickstein, Daniel P
AU  - Dickstein DP
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA; Bradley Hospital, 1011 Veterans 
      Memorial Parkway, East Providence, RI 02915, USA.
FAU - Hunt, Jeffrey I
AU  - Hunt JI
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA; Bradley Hospital, 1011 Veterans 
      Memorial Parkway, East Providence, RI 02915, USA.
FAU - Diler, Rasim S
AU  - Diler RS
AD  - Department of Psychiatry, Western Psychiatric Institute and Clinic, University of 
      Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Ryan, Neal D
AU  - Ryan ND
AD  - Department of Psychiatry, Western Psychiatric Institute and Clinic, University of 
      Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Gill, Mary Kay
AU  - Gill MK
AD  - Department of Psychiatry, Western Psychiatric Institute and Clinic, University of 
      Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
FAU - Axelson, David
AU  - Axelson D
AD  - Department of Psychiatry, Nationwide Children's Hospital and The Ohio State 
      College of Medicine, 1670 Upham Dr., Columbus, OH 43210, USA.
FAU - Yen, Shirley
AU  - Yen S
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Box G-BH, Providence, RI 02912, USA; Beth Israel Deaconess Medical 
      Center, Boston, MA 02115, USA.
LA  - eng
GR  - R01 MH059691/MH/NIMH NIH HHS/United States
GR  - R01 MH059929/MH/NIMH NIH HHS/United States
GR  - R01 MH112543/MH/NIMH NIH HHS/United States
GR  - R01 MH112544/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181226
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aging/*psychology
MH  - Bipolar Disorder/*psychology
MH  - Disability Evaluation
MH  - Employment/psychology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Social Adjustment
MH  - Young Adult
PMC - PMC6363880
MID - NIHMS1517735
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Longitudinal studies
OT  - Predictors
OT  - Psychosocial functioning
EDAT- 2019/01/04 06:00
MHDA- 2019/04/12 06:00
PMCR- 2020/03/01
CRDT- 2019/01/04 06:00
PHST- 2018/08/30 00:00 [received]
PHST- 2018/12/13 00:00 [revised]
PHST- 2018/12/24 00:00 [accepted]
PHST- 2019/01/04 06:00 [pubmed]
PHST- 2019/04/12 06:00 [medline]
PHST- 2019/01/04 06:00 [entrez]
PHST- 2020/03/01 00:00 [pmc-release]
AID - S0165-0327(18)31936-0 [pii]
AID - 10.1016/j.jad.2018.12.108 [doi]
PST - ppublish
SO  - J Affect Disord. 2019 Mar 1;246:578-585. doi: 10.1016/j.jad.2018.12.108. Epub 
      2018 Dec 26.