PMID- 30606444
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20190114
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 243
DP  - 2019 Jan
TI  - Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid 
      and homocysteine concentrations in dogs with chronic enteropathies and low 
      cobalamin concentrations.
PG  - 8-14
LID - S1090-0233(18)30165-5 [pii]
LID - 10.1016/j.tvjl.2018.11.004 [doi]
AB  - The objective of this study was to compare the effects of parenteral (PE) versus 
      oral (PO) cobalamin supplementation on serum methylmalonic acid (MMA) and 
      homocysteine (HCY) concentrations in dogs with hypocobalaminaemia. Thirty-six 
      dogs with serum cobalamin concentrations below 285ng/L (reference interval (RI): 
      244-959ng/L) were treated with PO (0.25-1.0mg daily) or PE cobalamin 
      (0.25-1.2mg/injection) using a block-randomized schedule. Serum MMA and HCY 
      concentrations were analysed at day 0, 28 and 90 after start of supplementation. 
      There was no significant difference between the PO and PE group regarding serum 
      MMA or HCY concentrations at any time point. Median (range, P comparing baseline 
      and 28 days, P comparing 28days and 90 days) serum MMA concentrations (nmol/L; RI 
      415-1193) were 932 (566-2468) in the PO and 943 (508-1900) in the PE group at 
      baseline, respectively, 705 (386-1465, P<0.0001) and 696 (377-932, P<0.0001) 
      after 28 days, and 739 (450-1221, P=0.58) and 690 (349-1145, P=0.76) after 90 
      days. Serum HCY concentrations (median (range), P comparing baseline and 28 days, 
      P comparing 28days and 90 days, mumol/L; RI 5.9-31.9) in the PO and PE groups were 
      12.2 (3.3-62.2) and 8.4 (3.7-34.8) at baseline, 12.5 (5.0-45.0, P=0.61) and 8.0 
      (3.8-18.3, P=0.28) after 28 days, and 17.7 (7.3-60.0 P=0.07) and 12.4 (6.3-33.1, 
      P=0.0007) after 90 days, respectively. Oral and parenteral cobalamin 
      supplementation had the same effect on serum MMA concentrations in this group of 
      dogs.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Toresson, L
AU  - Toresson L
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      Helsinki University, Agnes Sjobergin katu 2, 00014 Helsinki, Finland; Evidensia 
      Specialist Animal Hospital, Bergavagen 3, 25466 Helsingborg, Sweden. Electronic 
      address: linda.toresson@evidensia.se.
FAU - Steiner, J M
AU  - Steiner JM
AD  - Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas 
      A&M University, 4474 TAMU, College Station, TX 77843-4474, USA.
FAU - Spodsberg, E
AU  - Spodsberg E
AD  - Evidensia Specialist Animal Hospital, Bergavagen 3, 25466 Helsingborg, Sweden.
FAU - Olmedal, G
AU  - Olmedal G
AD  - Evidensia Specialist Animal Hospital, Bergavagen 3, 25466 Helsingborg, Sweden.
FAU - Suchodolski, J S
AU  - Suchodolski JS
AD  - Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas 
      A&M University, 4474 TAMU, College Station, TX 77843-4474, USA.
FAU - Lidbury, J A
AU  - Lidbury JA
AD  - Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas 
      A&M University, 4474 TAMU, College Station, TX 77843-4474, USA.
FAU - Spillmann, T
AU  - Spillmann T
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      Helsinki University, Agnes Sjobergin katu 2, 00014 Helsinki, Finland.
LA  - eng
PT  - Clinical Trial, Veterinary
PT  - Comparative Study
PT  - Journal Article
DEP - 20181112
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 8LL8S712J7 (Methylmalonic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - *Administration, Oral
MH  - Animals
MH  - Dietary Supplements/analysis
MH  - Dog Diseases/*drug therapy/etiology
MH  - Dogs
MH  - Female
MH  - Homocysteine/*blood
MH  - Infusions, Parenteral/*veterinary
MH  - Intestinal Diseases/complications/veterinary
MH  - Male
MH  - Methylmalonic Acid/*blood
MH  - Prospective Studies
MH  - Random Allocation
MH  - Vitamin B 12/*administration & dosage
MH  - Vitamin B 12 Deficiency/drug therapy/etiology/*veterinary
OTO - NOTNLM
OT  - Chronic enteropathy
OT  - Dog
OT  - Inflammatory bowel disease
OT  - Oral supplementation
OT  - Vitamin B12
EDAT- 2019/01/05 06:00
MHDA- 2019/01/15 06:00
CRDT- 2019/01/05 06:00
PHST- 2018/05/15 00:00 [received]
PHST- 2018/11/05 00:00 [revised]
PHST- 2018/11/07 00:00 [accepted]
PHST- 2019/01/05 06:00 [entrez]
PHST- 2019/01/05 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
AID - S1090-0233(18)30165-5 [pii]
AID - 10.1016/j.tvjl.2018.11.004 [doi]
PST - ppublish
SO  - Vet J. 2019 Jan;243:8-14. doi: 10.1016/j.tvjl.2018.11.004. Epub 2018 Nov 12.