PMID- 30606928
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20190422
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 139
IP  - 1
DP  - 2019
TI  - [The Investigation of Genes, Using an Improved Adenovirus Vector, and Food for 
      the Treatment and Prevention of Type 2 Diabetes Mellitus].
PG  - 47-51
LID - 10.1248/yakushi.18-00163-2 [doi]
AB  - Although many treatments for type 2 diabetes mellitus (T2DM) have been developed, 
      the quality of life for people with T2DM still tends to be lower than in those 
      without the disease. Thus, the development of new T2DM treatments and prevention 
      methods is required. Genetic predisposition and environmental factors are 
      understood to be involved in the onset and pathology of T2DM. Therefore, we have 
      attempted to explore genes and foods with potential for use in the treatment and 
      prevention of T2DM. LipoQuality, which describes the functional features of 
      diverse lipid species, has recently been a focus of study in the pathology of 
      metabolic diseases. Phospholipids, the major components of biological membranes, 
      are known to change in composition during the development of obesity and 
      diabetes. Therefore, for our research, we focused on genes that regulate the 
      composition of phospholipids. We examined the effects of such genes on T2DM using 
      an improved adenovirus vector that demonstrates safer, higher, and longer-term 
      transgene expression than that of the conventional adenovirus vector. We also 
      found that certain foods inhibit the progression of non-alcoholic fatty liver 
      disease, which is related to T2DM. In this review, we introduce our research 
      results, demonstrating how genes and food independently contribute to the 
      mechanisms of T2DM pathology.
FAU - Shimizu, Kahori
AU  - Shimizu K
AD  - Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University.
FAU - Nishinaka, Toru
AU  - Nishinaka T
AD  - Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University.
FAU - Tomita, Koji
AU  - Tomita K
AD  - Laboratory of Molecular Biology, Faculty of Pharmacy, Osaka Ohtani University.
FAU - Terada, Tomoyuki
AU  - Terada T
AD  - Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University.
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Phospholipids)
RN  - EC 2.3.1.23 (1-Acylglycerophosphocholine O-Acyltransferase)
SB  - IM
MH  - 1-Acylglycerophosphocholine O-Acyltransferase/physiology
MH  - *Adenoviridae
MH  - Animals
MH  - Diabetes Mellitus, Type 2/etiology/*prevention & control/*therapy
MH  - *Functional Food
MH  - Gene-Environment Interaction
MH  - *Genetic Vectors
MH  - Humans
MH  - Liver/metabolism
MH  - Mice
MH  - Non-alcoholic Fatty Liver Disease/prevention & control
MH  - Oxidative Stress
MH  - *Phospholipids/metabolism
MH  - *Vaccinium macrocarpon
OTO - NOTNLM
OT  - adenovirus vector
OT  - cranberry
OT  - diabetes
OT  - lysophospholipid acyltransferase
OT  - oxidative stress
EDAT- 2019/01/05 06:00
MHDA- 2019/04/23 06:00
CRDT- 2019/01/05 06:00
PHST- 2019/01/05 06:00 [entrez]
PHST- 2019/01/05 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
AID - 10.1248/yakushi.18-00163-2 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2019;139(1):47-51. doi: 10.1248/yakushi.18-00163-2.