PMID- 30607389
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240506
IS  - 2586-7296 (Electronic)
IS  - 2586-7210 (Print)
VI  - 26
IP  - 4
DP  - 2018 Dec
TI  - Pseudonormal or Restrictive Filling Pattern of Left Ventricle Predicts Poor 
      Prognosis in Patients with Ischemic Heart Disease Presenting as Acute Heart 
      Failure.
PG  - 217-225
LID - 10.4250/jcvi.2018.26.e22 [doi]
AB  - BACKGROUND: In patients with acute heart failure (AHF), diastolic dysfunction, 
      especially pseudonormal (PN) or restrictive filling pattern (RFP) of left 
      ventricle (LV), is considered to be implicated in a poor prognosis. However, 
      prognostic significance of diastolic dysfunction in patients with ischemic heart 
      disease (IHD) has been rarely investigated in Korea. METHODS: We enrolled 138 
      patients with IHD presenting as AHF and sinus rhythm during echocardiographic 
      study. Diastolic dysfunction of LV was graded as >/= 2 (group 1) or 1 (group 2) 
      according to usual algorithm using E/A ratio and deceleration time of mitral 
      inflow, E'/A' ratio of tissue Doppler echocardiography and left atrial size. 
      RESULTS: Patients in group 1 showed higher 2-year mortality rate (36.2% +/- 6.7%) 
      than those in group 2 (13.6% +/- 4.5%; p = 0.008). Two-year mortality rate of 
      patient with LV ejection fraction (LVEF) < 40% (26.8% +/- 6.0%) was not different 
      from those with LVEF 40%-49% (28.0% +/- 8.0%) or >/= 50% (13.7% +/- 7.4%; p = 0.442). 
      On univariate analysis, PN or RFP of LV, higher stage of chronic kidney disease 
      (CKD) and higher New York Heart Association (NYHA) functional class were poor 
      prognostic factors, but LVEF or older age >/= 75 years did not predict 2-year 
      mortality. On multivariate analysis, PN or RFP of LV (hazard ratio [HR], 2.52; 
      95% confidence interval [CI], 1.09-5.84; p = 0.031), higher stage of CKD (HR, 
      1.57; 95% CI, 1.14-2.17; p = 0.006) and higher NYHA functional class (HR, 1.81; 
      95% CI, 1.11-2.94; p = 0.017) were still significant prognostic factors for 
      2-year mortality. CONCLUSIONS: PN or RFP of LV was a more useful prognostic 
      factor for long-term mortality than LVEF in patients with IHD presenting as AHF.
FAU - Lee, Jae-Geun
AU  - Lee JG
AUID- ORCID: 0000-0003-4915-9584
AD  - Department of Internal Medicine, Jeju National University Hospital, Jeju National 
      University School of Medicine, Jeju, Korea.
FAU - Beom, Jong Wook
AU  - Beom JW
AUID- ORCID: 0000-0002-4503-6133
AD  - Department of Internal Medicine, Jeju National University Hospital, Jeju National 
      University School of Medicine, Jeju, Korea.
FAU - Choi, Joon Hyouk
AU  - Choi JH
AUID- ORCID: 0000-0003-4245-1582
AD  - Department of Internal Medicine, Jeju National University Hospital, Jeju National 
      University School of Medicine, Jeju, Korea.
FAU - Kim, Song-Yi
AU  - Kim SY
AUID- ORCID: 0000-0002-1170-8165
AD  - Department of Internal Medicine, Jeju National University Hospital, Jeju National 
      University School of Medicine, Jeju, Korea.
FAU - Kim, Ki-Seok
AU  - Kim KS
AUID- ORCID: 0000-0003-2847-7196
AD  - Department of Internal Medicine, Jeju National University Hospital, Jeju National 
      University School of Medicine, Jeju, Korea.
FAU - Joo, Seung-Jae
AU  - Joo SJ
AUID- ORCID: 0000-0002-4322-0703
AD  - Department of Internal Medicine, Jeju National University Hospital, Jeju National 
      University School of Medicine, Jeju, Korea.
LA  - eng
PT  - Journal Article
DEP - 20181001
PL  - Korea (South)
TA  - J Cardiovasc Imaging
JT  - Journal of cardiovascular imaging
JID - 101728106
PMC - PMC6310756
OTO - NOTNLM
OT  - Dysfunctions
OT  - Heart failure
OT  - Ischemic heart disease
OT  - Left ventricle
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2019/01/05 06:00
MHDA- 2019/01/05 06:01
PMCR- 2018/12/01
CRDT- 2019/01/05 06:00
PHST- 2018/07/04 00:00 [received]
PHST- 2018/09/09 00:00 [revised]
PHST- 2018/09/18 00:00 [accepted]
PHST- 2019/01/05 06:00 [entrez]
PHST- 2019/01/05 06:00 [pubmed]
PHST- 2019/01/05 06:01 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.4250/jcvi.2018.26.e22 [doi]
PST - ppublish
SO  - J Cardiovasc Imaging. 2018 Dec;26(4):217-225. doi: 10.4250/jcvi.2018.26.e22. Epub 
      2018 Oct 1.