PMID- 30607809
OWN - NLM
STAT- MEDLINE
DCOM- 20200318
LR  - 20200318
IS  - 1178-1661 (Electronic)
IS  - 1178-1653 (Linking)
VI  - 12
IP  - 4
DP  - 2019 Aug
TI  - EQ-5D-5L is More Responsive than EQ-5D-3L to Treatment Benefit of Cataract 
      Surgery.
PG  - 383-392
LID - 10.1007/s40271-018-00354-7 [doi]
AB  - BACKGROUND: It is not clear whether 5-level EQ-5D (EQ-5D-5L) utilities based on 
      recently developed value sets are more responsive than 3-level EQ-5D (EQ-5D-3L) 
      utilities. OBJECTIVES: The study aims were to compare (1) the responsiveness of 
      EQ-5D-5L and EQ-5D-3L utilities and (2) the responsiveness of these utilities 
      with the Short Form-6 Dimension (SF-6D) and Health Utilities Index Mark 3 (HUI3) 
      utilities to the treatment benefit of cataract surgery. METHODS: A total of 148 
      patients were interviewed before and after their cataract surgery using EQ-5D-3L, 
      EQ-5D-5L, SF-6D, and HUI3. Responsiveness was assessed for all measures using the 
      mean change (post-treatment-pre-treatment), standardized effect size (SES), 
      standardized response mean (SRM), and F-statistic. RESULTS: Using the Singapore 
      value sets, mean change for EQ-5D-3L and EQ-5D-5L utilities was 0.016 and 0.028, 
      SES was 0.097 and 0.199; SRM was 0.091 and 0.196; and F-statistic was 1.2 and 
      5.7, respectively. Similar trends were observed using the UK/England EQ-5D value 
      sets, although the magnitude was slightly smaller. The mean change, SES, SRM and 
      F-statistics for SF-6D (UK value set) were 0.020, 0.234, 0.249, and 9.2, 
      respectively. The values of mean change, SES, SRM and F-statistics for HUI3 
      (Canada value set) were 0.080, 0.472, 0.474, and 33.3, respectively. CONCLUSIONS: 
      The EQ-5D-5L utilities tend to be more responsive than the EQ-5D-3L utilities to 
      treatment benefits of cataract surgery. The HUI3 utilities are more responsive 
      than both the EQ-5D-5L and SF-6D, and SF-6D utilities may be slightly more 
      responsive than the EQ-5D-5L for assessing patients undergoing cataract surgery.
FAU - Gandhi, Mihir
AU  - Gandhi M
AUID- ORCID: 0000-0002-8902-2710
AD  - Department of Biostatistics, Singapore Clinical Research Institute, Singapore, 
      Singapore.
AD  - Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
AD  - Tampere Center for Child Health Research, University of Tampere and Tampere 
      University Hospital, Tampere, Finland.
FAU - Ang, Marcus
AU  - Ang M
AD  - Corneal and External Eye Disease Department, Singapore National Eye Centre, 11 
      Third Hospital Avenue, Singapore, Singapore. Marcus.Ang@Singhealth.com.sg.
AD  - Opthamology and Visual Sciences, Duke-NUS Medical School, Singapore, Singapore. 
      Marcus.Ang@Singhealth.com.sg.
FAU - Teo, Kelvin
AU  - Teo K
AD  - Corneal and External Eye Disease Department, Singapore National Eye Centre, 11 
      Third Hospital Avenue, Singapore, Singapore.
FAU - Wong, Chee Wai
AU  - Wong CW
AD  - Corneal and External Eye Disease Department, Singapore National Eye Centre, 11 
      Third Hospital Avenue, Singapore, Singapore.
FAU - Wei, Yvonne Chung-Hsi
AU  - Wei YC
AD  - Corneal and External Eye Disease Department, Singapore National Eye Centre, 11 
      Third Hospital Avenue, Singapore, Singapore.
FAU - Tan, Rachel Lee-Yin
AU  - Tan RL
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore, Singapore.
FAU - Janssen, Mathieu F
AU  - Janssen MF
AD  - Section Medical Psychology and Psychotherapy, Department of Psychiatry, Erasmus 
      MC, Rotterdam, Netherlands.
FAU - Luo, Nan
AU  - Luo N
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Patient
JT  - The patient
JID - 101309314
SB  - IM
MH  - Aged
MH  - Cataract Extraction/*statistics & numerical data
MH  - Cost-Benefit Analysis/*methods
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Interviews as Topic
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Patient Preference
MH  - Prospective Studies
MH  - Psychometrics
MH  - Quality of Life
MH  - Reproducibility of Results
MH  - Singapore
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires/*standards
MH  - Visual Acuity
EDAT- 2019/01/05 06:00
MHDA- 2020/03/19 06:00
CRDT- 2019/01/05 06:00
PHST- 2019/01/05 06:00 [pubmed]
PHST- 2020/03/19 06:00 [medline]
PHST- 2019/01/05 06:00 [entrez]
AID - 10.1007/s40271-018-00354-7 [pii]
AID - 10.1007/s40271-018-00354-7 [doi]
PST - ppublish
SO  - Patient. 2019 Aug;12(4):383-392. doi: 10.1007/s40271-018-00354-7.