PMID- 30610911
OWN - NLM
STAT- MEDLINE
DCOM- 20190711
LR  - 20190711
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 99
DP  - 2019 Apr
TI  - Social, self, (situational), and affective processes in medial prefrontal cortex 
      (MPFC): Causal, multivariate, and reverse inference evidence.
PG  - 311-328
LID - S0149-7634(18)30537-2 [pii]
LID - 10.1016/j.neubiorev.2018.12.021 [doi]
AB  - The medial prefrontal cortex (MPFC) has been posited to serve a variety of 
      social, affective, and cognitive functions. These conclusions have largely been 
      driven by forward inference analyses (e.g. GLM fMRI studies and meta-analyses) 
      that indicate where domain-specific tasks tend to produce activity but tell us 
      little about what those regions do. Here, we take a multi-method, multi-domain 
      approach to the functionality of MPFC subdivisions within Brodmann areas 9-11. We 
      consider four methods that each have reverse inference or causal inference value: 
      lesion work, transcranial magnetic stimulation, multivariate pattern analysis, 
      and Neurosynth analyses. The Neurosynth analyses include multi-term reverse 
      inference analyses that compare several domains of interest to one another at 
      once. We examine the evidence supporting structure-function links in five 
      domains: social cognition, self, value, emotional experience, and mental time 
      travel. The evidence is considered for each of three MPFC subdivisions: 
      dorsomedial prefrontal cortex (DMPFC), anteromedial prefrontal cortex (AMPFC), 
      and ventromedial prefrontal cortex (VMPFC). Although there is evidentiary 
      variability across methods, the results suggest that social processes are 
      functionally linked to DMPFC (and somewhat surprisingly in VMPFC), self processes 
      are linked to AMPFC, and affective processes are linked to AMPFC and VMPFC. There 
      is also a relatively non-selective region of VMPFC that may support situational 
      processing, a process key to each domain, but also independent of each.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Lieberman, Matthew D
AU  - Lieberman MD
AD  - UCLA Psychology Department, 1248 Franz Hall, Los Angeles, CA, 90095-1563, United 
      States. Electronic address: lieber@ucla.edu.
FAU - Straccia, Mark A
AU  - Straccia MA
AD  - UCLA Psychology Department, 1248 Franz Hall, Los Angeles, CA, 90095-1563, United 
      States.
FAU - Meyer, Meghan L
AU  - Meyer ML
AD  - Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 
      03755, USA.
FAU - Du, Meng
AU  - Du M
AD  - UCLA Psychology Department, 1248 Franz Hall, Los Angeles, CA, 90095-1563, United 
      States.
FAU - Tan, Kevin M
AU  - Tan KM
AD  - UCLA Psychology Department, 1248 Franz Hall, Los Angeles, CA, 90095-1563, United 
      States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190102
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
SB  - IM
CIN - Neurosci Biobehav Rev. 2019 May;100:208-210. PMID: 30836123
MH  - Brain Mapping/methods
MH  - Cognition/*physiology
MH  - Emotions/physiology
MH  - Humans
MH  - Prefrontal Cortex/*physiology
MH  - *Reward
MH  - *Social Behavior
OTO - NOTNLM
OT  - Medial prefrontal
OT  - Neurosynth
OT  - Reverse inference
EDAT- 2019/01/06 06:00
MHDA- 2019/07/12 06:00
CRDT- 2019/01/06 06:00
PHST- 2018/07/19 00:00 [received]
PHST- 2018/11/20 00:00 [revised]
PHST- 2018/12/18 00:00 [accepted]
PHST- 2019/01/06 06:00 [pubmed]
PHST- 2019/07/12 06:00 [medline]
PHST- 2019/01/06 06:00 [entrez]
AID - S0149-7634(18)30537-2 [pii]
AID - 10.1016/j.neubiorev.2018.12.021 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2019 Apr;99:311-328. doi: 10.1016/j.neubiorev.2018.12.021. 
      Epub 2019 Jan 2.