PMID- 30611552
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20210816
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 111
IP  - 3
DP  - 2019 Mar
TI  - Association between estrogen receptor 1 (ESR1) and leukemia inhibitory factor 
      (LIF) polymorphisms can help in the prediction of recurrent implantation failure.
PG  - 527-534
LID - S0015-0282(18)32211-8 [pii]
LID - 10.1016/j.fertnstert.2018.11.016 [doi]
AB  - OBJECTIVE: To investigate an association between polymorphisms related to the 
      implantation process that together could help in the prediction of recurrent 
      implantation failure (RIF). DESIGN: Cohort study. SETTING: Private fertility 
      center and reproductive genetics laboratory. PATIENT(S): Forty-four women 
      presenting RIF, who were included in study group (RIF group), and two control 
      groups, one with 63 women who were attended at our service and became pregnant 
      after the first IVF/intracytoplasmic sperm injection attempt (control group I) 
      and other with 65 fertile women who had at least two children without any 
      treatment and no history of miscarriage (control group II). INTERVENTION(S): 
      None. MAIN OUTCOME MEASURE(S): Genotyping was performed in the intron region of 
      TP63, VEGFA, MMP2, ESR1, and ESR2 genes and in the 3' untranslated region of the 
      LIF gene on genomic DNA using real-time polymerase chain reaction. RESULT(S): The 
      presence of ESR1/AA (rs12199722) and LIF/GT (rs929271) genotypes was more 
      frequent in the RIF group, leading to a 7.9-fold increase in the chance of women 
      presenting with RIF when compared with women who became pregnant on their first 
      cycle of IVF/intracytoplasmic sperm injection and a 2.8-fold increase when 
      compared with women who became pregnant without treatment. CONCLUSION(S): The 
      association between ESR1 and LIF polymorphisms can help in the prediction of RIF.
CI  - Copyright (c) 2018 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Vagnini, Laura Diniz
AU  - Vagnini LD
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil. 
      Electronic address: vagninilaura@cpdp.com.br.
FAU - Renzi, Adriana
AU  - Renzi A
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil.
FAU - Petersen, Bruna
AU  - Petersen B
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil.
FAU - Canas, Maria do Carmo Tomitao
AU  - Canas MDCT
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil.
FAU - Petersen, Claudia Guilhermino
AU  - Petersen CG
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil; 
      Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
FAU - Mauri, Ana Lucia
AU  - Mauri AL
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil; 
      Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
FAU - Mattila, Mariana Coltri
AU  - Mattila MC
AD  - Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
FAU - Ricci, Juliana
AU  - Ricci J
AD  - Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
FAU - Dieamant, Felipe
AU  - Dieamant F
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil; 
      Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
FAU - Oliveira, Joao Batista Alcantara
AU  - Oliveira JBA
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil; 
      Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
FAU - Baruffi, Ricardo Luiz Razera
AU  - Baruffi RLR
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil; 
      Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
FAU - Franco, Jose Goncalves Jr
AU  - Franco JG Jr
AD  - Paulista Center for Diagnosis, Research and Training, Ribeirao Preto, Brazil; 
      Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190102
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (3' Untranslated Regions)
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (LIF protein, human)
RN  - 0 (Leukemia Inhibitory Factor)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Adult
MH  - Case-Control Studies
MH  - Embryo Implantation/*genetics
MH  - Embryo Transfer/*adverse effects
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Fertilization in Vitro/*adverse effects
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Infertility, Female/diagnosis/*genetics/physiopathology/*therapy
MH  - Introns
MH  - Leukemia Inhibitory Factor/*genetics
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Real-Time Polymerase Chain Reaction
MH  - Sperm Injections, Intracytoplasmic/adverse effects
MH  - Treatment Failure
OTO - NOTNLM
OT  - ESR1
OT  - IVF/ICSI
OT  - LIF
OT  - recurrent implantation failure (RIF)
EDAT- 2019/01/07 06:00
MHDA- 2019/07/16 06:00
CRDT- 2019/01/07 06:00
PHST- 2018/08/04 00:00 [received]
PHST- 2018/10/19 00:00 [revised]
PHST- 2018/11/12 00:00 [accepted]
PHST- 2019/01/07 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2019/01/07 06:00 [entrez]
AID - S0015-0282(18)32211-8 [pii]
AID - 10.1016/j.fertnstert.2018.11.016 [doi]
PST - ppublish
SO  - Fertil Steril. 2019 Mar;111(3):527-534. doi: 10.1016/j.fertnstert.2018.11.016. 
      Epub 2019 Jan 2.