PMID- 30611942
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190318
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 246
DP  - 2019 Mar
TI  - Contaminants in Atlantic walruses in Svalbard Part 2: Relationships with 
      endocrine and immune systems.
PG  - 658-667
LID - S0269-7491(18)32196-1 [pii]
LID - 10.1016/j.envpol.2018.11.097 [doi]
AB  - Marine mammals in the Barents Sea region have among the highest levels of 
      contaminants recorded in the Arctic and the Atlantic walrus (Odobenus rosmarus 
      rosmarus) is one of the most contaminated species within this region. We 
      therefore investigated the relationships bewteen blubber concentrations of 
      lipophilic persistent organic pollutants (POPs) and plasma concentrations of 
      perfluoroalkyl substances (PFASs) and markers of endocrine and immune functions 
      in adult male Atlantic walruses (n = 38) from Svalbard, Norway. To do so, we 
      assessed plasma concentrations of five forms of thyroid hormones and transcript 
      levels of genes related to the endocrine and immune systems as endpoints; 
      transcript levels of seven genes in blubber and 23 genes in blood cells were 
      studied. Results indicated that plasma total thyroxine (TT4) concentrations and 
      ratio of TT4 and reverse triiodothyronine decreased with increasing blubber 
      concentrations of lipophilic POPs. Blood cell transcript levels of genes involved 
      in the function of T and B cells (FC like receptors 2 and 5, cytotoxic 
      T-lymphocyte associated protein 4 and protein tyrosine phosphatase non-receptor 
      type 22) were increased with plasma PFAS concentrations. These results suggest 
      that changes in thyroid and immune systems in adult male walruses are linked to 
      current levels of contaminant exposure.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Routti, Heli
AU  - Routti H
AD  - Norwegian Polar Institute, Fram Centre, Tromso, Norway; University of Siena, 
      Siena, Italy. Electronic address: heli.routti@npolar.no.
FAU - Diot, Beatrice
AU  - Diot B
AD  - UiT, The Arctic University of Norway, Tromso, Norway.
FAU - Panti, Cristina
AU  - Panti C
AD  - University of Siena, Siena, Italy.
FAU - Duale, Nur
AU  - Duale N
AD  - Norwegian Institute of Public Health, Oslo, Norway.
FAU - Fossi, Maria Cristina
AU  - Fossi MC
AD  - University of Siena, Siena, Italy.
FAU - Harju, Mikael
AU  - Harju M
AD  - Norwegian Institute for Air Research, Fram Centre, Tromso, Norway.
FAU - Kovacs, Kit M
AU  - Kovacs KM
AD  - Norwegian Polar Institute, Fram Centre, Tromso, Norway.
FAU - Lydersen, Christian
AU  - Lydersen C
AD  - Norwegian Polar Institute, Fram Centre, Tromso, Norway.
FAU - Scotter, Sophie E
AU  - Scotter SE
AD  - UiT, The Arctic University of Norway, Tromso, Norway.
FAU - Villanger, Gro D
AU  - Villanger GD
AD  - Norwegian Institute of Public Health, Oslo, Norway.
FAU - Bourgeon, Sophie
AU  - Bourgeon S
AD  - UiT, The Arctic University of Norway, Tromso, Norway.
LA  - eng
PT  - Journal Article
DEP - 20181130
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 0 (Thyroid Hormones)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Animals
MH  - Arctic Regions
MH  - Endocrine Disruptors/*analysis/blood
MH  - Hydrocarbons, Fluorinated/*analysis/blood
MH  - Immune System/*drug effects
MH  - Male
MH  - Svalbard
MH  - Thyroid Hormones/*blood/genetics
MH  - Walruses/*blood/immunology
MH  - Water Pollutants, Chemical/*analysis/blood
OTO - NOTNLM
OT  - Marine mammal
OT  - Pollutant
OT  - Thyroid hormone
OT  - mRNA
OT  - qPCR
EDAT- 2019/01/07 06:00
MHDA- 2019/03/19 06:00
CRDT- 2019/01/07 06:00
PHST- 2018/05/16 00:00 [received]
PHST- 2018/11/27 00:00 [revised]
PHST- 2018/11/28 00:00 [accepted]
PHST- 2019/01/07 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2019/01/07 06:00 [entrez]
AID - S0269-7491(18)32196-1 [pii]
AID - 10.1016/j.envpol.2018.11.097 [doi]
PST - ppublish
SO  - Environ Pollut. 2019 Mar;246:658-667. doi: 10.1016/j.envpol.2018.11.097. Epub 
      2018 Nov 30.