PMID- 30614019
OWN - NLM
STAT- MEDLINE
DCOM- 20190605
LR  - 20200225
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 42
IP  - 3
DP  - 2019 Mar
TI  - Pulmonary vascular resistance index: Getting the units right and why it matters.
PG  - 334-338
LID - 10.1002/clc.23151 [doi]
AB  - Pulmonary vascular resistance (PVR) and PVR index (PVRI) are key variables in a 
      broad range of contexts, including prediction of outcomes in heart and liver 
      transplantation, determining candidacy for closure of atrial or ventricular 
      septal defects, and guiding treatment of pulmonary hypertension. Significant 
      variability exists among the units used to report PVRI in current literature, 
      making the interpretation of data and translation into clinical practice 
      difficult. Here, we will review the measurement and derivation of PVR and PVRI 
      and demonstrate the extent of confusion in the literature. We conducted a 
      literature search of all published articles in PubMed using the term "PVRI." This 
      yielded 218 sources with defined units for PVRI, including 33 unique variants. 
      Among all reviewed literature, 45.4% of sources reported PVRI with units ending 
      in m(2) (meters squared), which we defined as correct, whereas 54.6% reported 
      PVRI with units not ending in m(2) , which we defined as incorrect. This lack of 
      uniformity has led to considerable confusion among researchers and clinicians, 
      with potentially life-altering consequences.
CI  - (c) 2019 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.
FAU - Kwan, Wilson C
AU  - Kwan WC
AUID- ORCID: 0000-0002-5313-3646
AD  - Division of Cardiovascular Medicine, Keck School of Medicine of the University of 
      Southern California, Los Angeles, California.
FAU - Shavelle, David M
AU  - Shavelle DM
AD  - Division of Cardiovascular Medicine, Keck School of Medicine of the University of 
      Southern California, Los Angeles, California.
FAU - Laughrun, David R
AU  - Laughrun DR
AD  - Division of Cardiovascular Medicine, Keck School of Medicine of the University of 
      Southern California, Los Angeles, California.
LA  - eng
PT  - Editorial
PT  - Review
DEP - 20190227
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Humans
MH  - Hypertension, Pulmonary/*physiopathology
MH  - Pulmonary Artery/*physiopathology
MH  - Pulmonary Wedge Pressure/*physiology
MH  - Risk Factors
MH  - Vascular Resistance/*physiology
PMC - PMC6712411
COIS- The authors declare no potential conflict of interests.
EDAT- 2019/01/08 06:00
MHDA- 2019/06/06 06:00
PMCR- 2019/02/27
CRDT- 2019/01/08 06:00
PHST- 2018/10/30 00:00 [received]
PHST- 2018/12/20 00:00 [revised]
PHST- 2019/01/03 00:00 [accepted]
PHST- 2019/01/08 06:00 [pubmed]
PHST- 2019/06/06 06:00 [medline]
PHST- 2019/01/08 06:00 [entrez]
PHST- 2019/02/27 00:00 [pmc-release]
AID - CLC23151 [pii]
AID - 10.1002/clc.23151 [doi]
PST - ppublish
SO  - Clin Cardiol. 2019 Mar;42(3):334-338. doi: 10.1002/clc.23151. Epub 2019 Feb 27.