PMID- 30614662
OWN - NLM
STAT- MEDLINE
DCOM- 20200312
LR  - 20200312
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 11
IP  - 9
DP  - 2019 Sep
TI  - Diverse human leukocyte antigen association of type 1 diabetes in north India.
PG  - 719-728
LID - 10.1111/1753-0407.12898 [doi]
AB  - BACKGROUND: Type 1 diabetes (T1D) is a complex disease, with involvement of 
      various susceptibility genes. Human leukocyte antigen (HLA) on chromosome 6p21 is 
      major susceptibility region. This study examined genetic association of HLA genes 
      with T1D. METHODS: The study recruited 259 T1D patients and 706 controls from 
      north India. PCR-SSP and LiPA were used to type HLA Class I and II alleles. 
      RESULTS: At HLA Class I locus, HLA-A*02, A*26, B*08 and B*50 were significantly 
      increased in patients vs controls (39.8% vs 28.9% [Bonferroni-corrected P P(c) 
       = 0.032], 24.7% vs 9.6% [P(c)  = 4.83 x 10(-8) ], 37.2% vs 15.7% [P(c) 
       = 1.92 x 10(-9) ], and 19.4% vs 5.5% [P(c)  = 4.62 x 10(-9) ], respectively). 
      Similarly, in Class II region, DRB1*03 showed a strong positive association with 
      T1D (78.7% vs 17.5% in controls; P = 1.02 x 10(-9) ). Association of DRB1*04 with 
      T1D (28.3% vs 15.5% in controls; P(c)  = 3.86 x 10(-4) ) was not independent of 
      DRB1*03. Negative associations were found between T1D and DRB1*07, *11, *13, and 
      *15 (13.8% vs 26.1% in controls [P(c)  = 0.00175], 3.9% vs 16.9% in controls 
      [P(c)  = 6.55x 10(-6) ], 5.5% vs 21.6% in controls [P(c)  = 2.51 x 10(-7) ], and 
      16.9% vs 43.9% in controls [P(c)  = 9.94x 10(-10) ], respectively). Compared with 
      controls, patients had significantly higher haplotype frequencies of 
      A*26-B*08-DRB1*03-DQA1*05-DQB1*02 (10.43% vs 1.96%; P = 7.62 x 10(-11) ), 
      A*02-B*50-DRB1*03-DQA1*05-DQB1*02 (6.1% vs 0.71%; P = 2.19 x 10(-10) ), 
      A*24-B*08-DRB1*03-DQA1*05-DQB1*02 (4.72% vs 0.8%; P = 5.4 x 10(-7) ), 
      A*02-B*08-DRB1*03-DQA1*05-DQB1*02 (2.36% vs 0.18%; P = 3.6 x 10(-5) ), and 
      A*33-B*58-DRB1*03-DQA1*05-DQB1*02 (4.33% vs 1.25%; P = 0.00019). CONCLUSIONS: In 
      north India, T1D is independently associated only with HLA-DRB1*03 haplotypes, 
      and is negatively associated with DRB1*07, *11, *13, and *15.
CI  - (c) 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Kumar, Neeraj
AU  - Kumar N
AUID- ORCID: 0000-0002-3535-9019
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Mehra, Narinder K
AU  - Mehra NK
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Kanga, Uma
AU  - Kanga U
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Kaur, Gurvinder
AU  - Kaur G
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Tandon, Nikhil
AU  - Tandon N
AUID- ORCID: 0000-0003-4604-1986
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, New Delhi, India.
FAU - Chuzho, Neihenuo
AU  - Chuzho N
AD  - Indian Council of Medical Research (ICMR)-National Institute of Pathology, 
      Safdarjang Hospital Campus, New Delhi, India.
FAU - Mishra, Gunja
AU  - Mishra G
AD  - Indian Council of Medical Research (ICMR)-National Institute of Pathology, 
      Safdarjang Hospital Campus, New Delhi, India.
FAU - Neolia, Shekhar C
AU  - Neolia SC
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi, India.
LA  - eng
GR  - Department of Biotechnology, Ministry of Science and Technology, Science and 
      Engineering Research Board, Government of India/
GR  - Indian Council of Medical Research/
PT  - Journal Article
DEP - 20190207
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/pathology
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - India/epidemiology
MH  - Prognosis
OTO - NOTNLM
OT  - 1型糖尿病
OT  - association
OT  - human leukocyte antigen
OT  - north India
OT  - type 1 diabetes
OT  - 人类白细胞抗原
OT  - 印度北部
OT  - 相关性
EDAT- 2019/01/08 06:00
MHDA- 2020/03/13 06:00
CRDT- 2019/01/08 06:00
PHST- 2018/09/10 00:00 [received]
PHST- 2018/11/29 00:00 [revised]
PHST- 2019/01/03 00:00 [accepted]
PHST- 2019/01/08 06:00 [pubmed]
PHST- 2020/03/13 06:00 [medline]
PHST- 2019/01/08 06:00 [entrez]
AID - 10.1111/1753-0407.12898 [doi]
PST - ppublish
SO  - J Diabetes. 2019 Sep;11(9):719-728. doi: 10.1111/1753-0407.12898. Epub 2019 Feb 
      7.