PMID- 30615542
OWN - NLM
STAT- MEDLINE
DCOM- 20190626
LR  - 20190626
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 22
IP  - 3
DP  - 2019 Mar
TI  - LB-9, Novel Probiotic Lactic Acid Bacteria, Ameliorates Dextran Sodium 
      Sulfate-Induced Colitis in Mice by Inhibiting TNF-alpha-Mediated Apoptosis of 
      Intestinal Epithelial Cells.
PG  - 271-276
LID - 10.1089/jmf.2018.4236 [doi]
AB  - Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's 
      disease, is a group of chronic and relapsing inflammatory conditions within the 
      gastrointestinal tract. An increase in intestinal epithelial cell (IEC) apoptosis 
      is a major characteristic of UC. Tumor necrosis factor-alpha (TNF-alpha) plays an 
      essential role in the regulation of apoptosis. Aberrant activation of the immune 
      response to resident microflora contributes to overproduction of TNF-alpha in the 
      mucosal tissue of the gastrointestinal tract; a hallmark of UC. There are no 
      curative medications for IBD. Thus, establishment of novel strategies for the 
      treatment of this disease is imperative. Lactic acid bacteria (LAB) have been 
      characterized as probiotics that can alleviate imbalances in indigenous 
      microflora in UC, exhibiting beneficial effects for the treatment and prevention 
      of IBD. In this study, we elucidate the potential of LB-9, a novel probiotic LAB, 
      to protect against colitis development using a dextran sodium sulfate 
      (DSS)-induced mouse model of UC. Treatment using LB-9 reduced clinical symptoms 
      of colitis. In addition, both colitis-induced and NF-kappaB-mediated IEC apoptosis 
      was markedly reduced in mice treated with LB-9. Moreover, these results were 
      closely associated with reduced TNF-alpha levels. Our study demonstrates that the 
      LB-9 probiotic exhibits therapeutic potential for UC through suppression of 
      TNF-alpha-mediated IEC apoptosis in a murine DSS-induced colitis model, with 
      important biological implications for treatment of IBD in humans.
FAU - Chae, Jung Min
AU  - Chae JM
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Chang, Moon Han
AU  - Chang MH
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Heo, Wan
AU  - Heo W
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Cho, Hyung Taek
AU  - Cho HT
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Lee, Dong Hun
AU  - Lee DH
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Hwang, Bo Byeol
AU  - Hwang BB
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Kim, Jin Woo
AU  - Kim JW
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Yoon, Seok Min
AU  - Yoon SM
AD  - 2 Lotte R&D Center, Seoul, Korea.
FAU - Yang, Siyoung
AU  - Yang S
AD  - 2 Lotte R&D Center, Seoul, Korea.
FAU - Lee, Jin Hyup
AU  - Lee JH
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Kim, Young Jun
AU  - Kim YJ
AD  - 1 Department of Food and Biotechnology, Korea University, Sejong, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190107
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Colitis, Ulcerative/*drug therapy/etiology/metabolism/physiopathology
MH  - Dextran Sulfate/adverse effects
MH  - Epithelial Cells/cytology/*drug effects/metabolism
MH  - Humans
MH  - Intestines/cytology/drug effects
MH  - Lactobacillales/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/genetics/metabolism
MH  - Probiotics/*administration & dosage
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
EDAT- 2019/01/08 06:00
MHDA- 2019/06/27 06:00
CRDT- 2019/01/08 06:00
PHST- 2019/01/08 06:00 [pubmed]
PHST- 2019/06/27 06:00 [medline]
PHST- 2019/01/08 06:00 [entrez]
AID - 10.1089/jmf.2018.4236 [doi]
PST - ppublish
SO  - J Med Food. 2019 Mar;22(3):271-276. doi: 10.1089/jmf.2018.4236. Epub 2019 Jan 7.