PMID- 30616417
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20200225
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 47
IP  - 2
DP  - 2019 Feb
TI  - Effects of Xiaotan Tongfu decoction on hepatic metastasis in obesity-associated 
      colorectal cancer.
PG  - 915-925
LID - 10.1177/0300060518813689 [doi]
AB  - OBJECTIVE: This study was performed to assess the influence of obesity on 
      colorectal cancer (CRC) and investigate the efficacy of Xiaotan Tongfu (XTTF) 
      decoction to CRC treatment. METHODS: BALB/C mice were used to establish an 
      obesity-associated CRC model by a high-fat diet and tumor implantation. The 
      tumors were harvested from mice inoculated with CT26 cell suspension. Body 
      weight, liver weight, hepatic metastasis, and histological changes were observed. 
      Immunohistochemical analysis and real-time polymerase chain reaction were 
      performed to measure the levels of insulin-like growth factor 1 (IGF-1), IGF-1 
      receptor (IGF-1R), and IGF binding protein 3 (IGFBP-3). RESULTS: Obesity 
      influenced the secretion of IGFs and aggravated CRC, while XTTF decoction 
      inhibited the process of hepatic metastasis in CRC by upregulating the secretion 
      of IGF-1/IGF-1R and downregulating the secretion of IGFBP-3. CONCLUSIONS: This 
      study provides evidence that XTTF decoction can serve as a candidate curative 
      treatment for CRC.
FAU - Zhao, Ying
AU  - Zhao Y
AD  - Department of Traditional Chinese Medicine, Changzheng Hospital, Navy Medical 
      University (Second Military Medical University), Shanghai, China.
FAU - Xiu, Lijuan
AU  - Xiu L
AD  - Department of Traditional Chinese Medicine, Changzheng Hospital, Navy Medical 
      University (Second Military Medical University), Shanghai, China.
FAU - Li, Yongjin
AU  - Li Y
AD  - Department of Traditional Chinese Medicine, Changzheng Hospital, Navy Medical 
      University (Second Military Medical University), Shanghai, China.
FAU - Lu, Ye
AU  - Lu Y
AD  - Department of Traditional Chinese Medicine, Changzheng Hospital, Navy Medical 
      University (Second Military Medical University), Shanghai, China.
FAU - Wang, Xiaowei
AU  - Wang X
AD  - Department of Traditional Chinese Medicine, Changzheng Hospital, Navy Medical 
      University (Second Military Medical University), Shanghai, China.
FAU - Wei, Pinkang
AU  - Wei P
AD  - Department of Traditional Chinese Medicine, Changzheng Hospital, Navy Medical 
      University (Second Military Medical University), Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20190107
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (xiaotan tongfu)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Proliferation
MH  - Colorectal Neoplasms/*drug therapy/etiology/metabolism/pathology
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Insulin-Like Growth Factor Binding Protein 3/metabolism
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Liver Neoplasms/*drug therapy/etiology/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Obesity/*complications
MH  - Receptor, IGF Type 1/metabolism
MH  - Tumor Cells, Cultured
PMC - PMC6381456
OTO - NOTNLM
OT  - Colorectal cancer
OT  - Xiaotan Tongfu decoction
OT  - hepatic metastasis
OT  - insulin-like growth factor 1
OT  - insulin-like growth factor 1 receptor
OT  - insulin-like growth factor binding protein 3
OT  - obesity
EDAT- 2019/01/09 06:00
MHDA- 2019/06/14 06:00
PMCR- 2019/02/01
CRDT- 2019/01/09 06:00
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 10.1177_0300060518813689 [pii]
AID - 10.1177/0300060518813689 [doi]
PST - ppublish
SO  - J Int Med Res. 2019 Feb;47(2):915-925. doi: 10.1177/0300060518813689. Epub 2019 
      Jan 7.