PMID- 30618227
OWN - NLM
STAT- MEDLINE
DCOM- 20190702
LR  - 20190702
IS  - 1827-1839 (Electronic)
IS  - 0392-9590 (Linking)
VI  - 38
IP  - 1
DP  - 2019 Feb
TI  - The relationship between platelet-to-lymphocyte ratio and pulmonary embolism 
      severity in acute pulmonary embolism.
PG  - 4-9
LID - 10.23736/S0392-9590.18.04028-2 [doi]
AB  - BACKGROUND: The aim of this study was to determine the level of 
      platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in 
      patients with acute pulmonary embolism (APE) according to high and low risk for 
      early mortality based on simplified Pulmonary Embolism Severity Index (sPESI). In 
      addition, it was investigated the relationship between PLR and NLR with systolic 
      pulmonary artery pressure (sPAP), cardiac markers, disease severity and hospital, 
      1th month, 3th month and 3-month total mortality. METHODS: Our hospital's 
      electronic patient database was searched for the patients with APE during last 
      year and eighty-two patients retrospectively evaluated. Plasma D-dimer, troponin 
      I (TnI), brain natriuretic peptide (BNP), hemogram values, sPAP from 
      echocardiographic findings were recorded from database system. Hospital mortality 
      was determined from files of cases and 1th, 3th month mortality and survival 
      information were determined by phone calls with the patient and/or relatives. 
      RESULTS: A percentage of 67.1% (55) of APE cases had sPESI>/=1. There was no 
      significant difference for age and sex between high and low risk patients 
      according to sPESI (P>0.05). The mean serum BNP, TnI, sPAP, neutrophil counts, 
      platelet counts, PLR and NLR was statistically increased and lymphocyte counts 
      was statistically decreased in high risk patients according to sPESI compared 
      with low risk patients (P<0.01 for BNP, PLR and NLR; P<0.05 for TnI, sPAP, 
      neutrophil and platelet; P<0.01 for lymphocyte). There was no significantly 
      difference for hospital and total 3-month mortality between high and low risk 
      patients (P>0.05). When the cut-off value of PLO was taken as >/=156 by ROC 
      analysis for the predicting of high sPESI, PLR had an area under the curve (AUC) 
      in the receiver operating characteristic (ROC) curve of 0.704 (0.591-0.816; 95% 
      CI; P<0.01) and the cut-off value of NLR was taken as >/=3.56 by ROC analysis for 
      the predicting of high sPESI, NLR had an area under the curve (AUC) in the 
      receiver operating characteristic (ROC) curve of 0.675 (0.556-0.794; 95% CI; 
      P<0.05). An NLR level of 3.56 was taken as the cut-off between high and low risk 
      patients according to sPESI, NLR had a sensitivity of 66% and specificity of 53%. 
      When the cases were evaluated as two groups according to the cut-off value of 
      156; total 3-month mortality was statistically increased (chi2=6.896, P<0.01) and 
      when the cases were evaluated as two groups according to the based NLR cut-off 
      value of 3.56; hospital mortality, 3th month mortality and total 3-month 
      mortality was statistically increased (chi2=4.771, P<0.05; chi2=4.383, P<0.05; 
      chi2=9.101, P<0.01 respectively). CONCLUSIONS: PLR and NLR increased in patients 
      with high risk, and PLR may have predicting value for 3-month mortality while NLR 
      may have predicting value for hospital mortality, 3th month mortality and total 
      3-month mortality in patients with APE.
FAU - Telo, Selda
AU  - Telo S
AD  - Department of Biochemistry, School of Medicine, Firat University, Elazig, Turkey.
FAU - Kuluozturk, Mutlu
AU  - Kuluozturk M
AD  - Department of Chest Disease, Elazig Training and Research Hospital, Health 
      Sciences University, Elazig, Turkey.
FAU - Deveci, Figen
AU  - Deveci F
AD  - Department of Chest Disease, Firat University, School of Medicine, Elazig, Turkey 
      - fgndeveci@yahoo.com.
FAU - Kirkil, Gamze
AU  - Kirkil G
AD  - Department of Chest Disease, Firat University, School of Medicine, Elazig, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190104
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Platelets/*cytology
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Logistic Models
MH  - Lymphocyte Count
MH  - Lymphocytes/*cytology
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Pulmonary Embolism/blood/*diagnosis/mortality
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2019/01/09 06:00
MHDA- 2019/07/03 06:00
CRDT- 2019/01/09 06:00
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/07/03 06:00 [medline]
PHST- 2019/01/09 06:00 [entrez]
AID - S0392-9590.18.04028-2 [pii]
AID - 10.23736/S0392-9590.18.04028-2 [doi]
PST - ppublish
SO  - Int Angiol. 2019 Feb;38(1):4-9. doi: 10.23736/S0392-9590.18.04028-2. Epub 2019 
      Jan 4.