PMID- 30618393
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20190501
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 284
DP  - 2018 Nov
TI  - IMPLICATION OF RELATIONSHIP BETWEEN OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN 
      BLOOD SERUM.
PG  - 71-76
AB  - Aim of the study was to examine the relationship between oxidative stress and 
      overtraining syndrome in athletes by evaluation in serum oxidative and 
      antioxidant status. In 43 athletes with non-functional overreaching 
      (NFO)/overtraining syndrome(OTS) and 40 athletes without NFO/OTS -control 
      athletes (CA), diacron-reactive oxygen metabolites (d-ROMs) and biological 
      antioxidant potential (BAP) in serum, as well as ratio of d-ROMs and BAP test 
      measurements - marker of oxidative stress, were assessed. Baseline data 
      collection performed in both groups of athletes - with NFO/OTS and CA, followed 
      by data collection in athletes with NFO/OTS after 28 days of rest. In athletes 
      suspicious for OTS all measurements were performed after 2 more months of rest. 
      Results of the study showed higher baseline d-ROMs in NFO/OTS athletes than in 
      athletes without NFO/OTS, whereas antioxidant potential in CA was significantly 
      higher, than in NFO/OTS athletes, After 28 days of rest there was significant 
      decrease in d-ROM values in both: athletes with NFO and with OTS, as well as 
      normalization of antioxidant status in athletes with NFO. Total 3 month of rest 
      showed improvement in the oxidative status of athletes with OTS, reaching normal 
      values, though antioxidant status remained without significant improvement, 
      showing subnormal BAP values and decreased BAP/d-ROM ratio. The results 
      demonstrate increased oxidative stress in overtraining state, creating disbalance 
      between d-ROM production and antioxidant capacity. Thus, prolonged imbalance 
      between oxidant production and antioxidant protection via attenuation of 
      antioxidant capacity can be a cause of overtraining in highly trained athletes. 
      In this study most frequently NFO and OTS were seen in wrestling, which needs 
      further investigation and regular medical monitoring.
FAU - Kajaia, T
AU  - Kajaia T
AD  - Tbilisi State Medical University, Georgia.
FAU - Maskhulia, L
AU  - Maskhulia L
AD  - Tbilisi State Medical University, Georgia.
FAU - Chelidze, K
AU  - Chelidze K
AD  - Tbilisi State Medical University, Georgia.
FAU - Akhalkatsi, V
AU  - Akhalkatsi V
AD  - Tbilisi State Medical University, Georgia.
FAU - Mchedlidze, T
AU  - Mchedlidze T
AD  - Tbilisi State Medical University, Georgia.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Antioxidants/*analysis
MH  - Athletic Performance/*physiology
MH  - Biomarkers/blood
MH  - Humans
MH  - Male
MH  - Monitoring, Physiologic
MH  - Oxidative Stress/*physiology
MH  - Reactive Oxygen Species/*blood
MH  - Young Adult
EDAT- 2019/01/09 06:00
MHDA- 2019/05/02 06:00
CRDT- 2019/01/09 06:00
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2018 Nov;(284):71-76.