PMID- 30618575
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 12
DP  - 2018
TI  - Common Variants in PLXNA4 and Correlation to CSF-related Phenotypes in 
      Alzheimer's Disease.
PG  - 946
LID - 10.3389/fnins.2018.00946 [doi]
LID - 946
AB  - The Plexin-A 4 (PLXNA4) gene, has recently been identified in genome wide 
      association studies (GWAS), as a novel genetic player associated with Alzheimer's 
      disease (AD). Additionally, PLXNA4 genetic variations were also found to increase 
      AD risk by tau pathology in vitro. However, the potential roles of PLXNA4 
      variants in the amyloid-beta (Abeta) pathology, were not evaluated. Five targeted loci 
      capturing the top common variations in PLXNA4, were extracted using tagger 
      methods. Multiple linear regression models were used to explore whether these 
      variations can affect the cerebrospinal fluid (CSF) (Abeta(1-42), T-tau, and P-tau) 
      phenotypes in the Alzheimer's disease Neuroimaging Initiative (ADNI) dataset. We 
      detected that two loci (rs6467431, rs67468325) were significantly associated with 
      CSF Abeta(1-42) levels in the hybrid population (rs6467431: P = 0.01376, rs67468325: 
      P = 0.006536) and the significance remained after false discovery rate (FDR) 
      correction (rs6467431: Pc = 0.03441, rs67468325: Pc = 0.03268). In the subgroup 
      analysis, we further confirmed the association of rs6467431 in the cognitively 
      normal (CN) subgroup (P = 0.01904, Pc = 0.04761). Furthermore, rs6467431-A 
      carriers and rs67468325-G carriers showed higher CSF Abeta(1-42) levels than 
      non-carriers. Nevertheless, we did not detect any significant relationships 
      between the levels of T-tau, P-tau and these PLXNA4 loci. Our findings provided 
      preliminary evidence that PLXNA4 variants can confer AD risk through modulating 
      the Abeta deposition.
FAU - Han, Qiu
AU  - Han Q
AD  - Department of Neurology, Qingdao Clinical Medical School, Qingdao Municipal 
      Hospital, Nanjing Medical University, Qingdao, China.
AD  - Department of Neurology, The Affiliated Huaian Hosipital of Xuzhou Medical 
      University, Huai'an, China.
FAU - Sun, Yong-An
AU  - Sun YA
AD  - Department of Neurology, Qingdao Clinical Medical School, Qingdao Municipal 
      Hospital, Nanjing Medical University, Qingdao, China.
AD  - Department of Neurology, First Affiliated Hospital of Kangda School, Nanjing 
      Medical University, Lianyungang, China.
FAU - Zong, Yu
AU  - Zong Y
AD  - Department of Neurology, School of Medicine, Qingdao Municipal Hospital, Qingdao 
      University, Qingdao, China.
FAU - Chen, Chun
AU  - Chen C
AD  - Department of Neurology, Qingdao Clinical Medical School, Qingdao Municipal 
      Hospital, Nanjing Medical University, Qingdao, China.
AD  - Department of Neurology, Hongze Huai'an District People's Hospital, Huai'an, 
      China.
FAU - Wang, Hui-Fu
AU  - Wang HF
AD  - Department of Neurology, School of Medicine, Qingdao Municipal Hospital, Qingdao 
      University, Qingdao, China.
FAU - Tan, Lan
AU  - Tan L
AD  - Department of Neurology, Qingdao Clinical Medical School, Qingdao Municipal 
      Hospital, Nanjing Medical University, Qingdao, China.
CN  - Alzheimer's Disease Neuroimaging Initiative
LA  - eng
GR  - U01 AG024904/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20181218
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC6305543
OTO - NOTNLM
OT  - Alzheimer's disease (AD)
OT  - Plexin-A 4 (PLXNA4)
OT  - amyloid-beta (Abeta)
OT  - association
OT  - variant
EDAT- 2019/01/09 06:00
MHDA- 2019/01/09 06:01
PMCR- 2018/01/01
CRDT- 2019/01/09 06:00
PHST- 2018/09/06 00:00 [received]
PHST- 2018/11/29 00:00 [accepted]
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/01/09 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2018.00946 [doi]
PST - epublish
SO  - Front Neurosci. 2018 Dec 18;12:946. doi: 10.3389/fnins.2018.00946. eCollection 
      2018.