PMID- 30618656
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 1662-5137 (Print)
IS  - 1662-5137 (Electronic)
IS  - 1662-5137 (Linking)
VI  - 12
DP  - 2018
TI  - Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a 
      Model of Chronic Migraine-Associated Hyperalgesia.
PG  - 63
LID - 10.3389/fnsys.2018.00063 [doi]
LID - 63
AB  - The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia 
      in mice. This model has been used to study the neurological disorder of 
      trigeminovascular pain or migraine, a debilitating form of hyperalgesia. The 
      present study validates hyperalgesia in an established mouse model of chronic 
      migraine triggered by NTG and advances the understanding of the associated 
      molecular mechanisms. The RNA-seq profiles of two nervous system regions 
      associated with pain, the trigeminal ganglia (TG) and the nucleus accumbens 
      (NAc), were compared in mice receiving chronic NTG treatment relative to control 
      (CON) mice. Among the 109 genes that exhibited an NTG treatment-by-region 
      interaction, solute carrier family 32 (GABA vesicular transporter) member 1 
      (Slc32a1) and preproenkephalin (Penk) exhibited reversal of expression patterns 
      between the NTG and CON groups. Erb-b2 receptor tyrosine kinase 4 (Erbb4) and 
      solute carrier family 1 (glial high affinity glutamate transporter) member 2 
      (Slc1a2) exhibited consistent differential expression between treatments across 
      regions albeit at different magnitude. Period circadian clock 1 (Per1) was among 
      the 165 genes that exhibited significant NTG treatment effect. Biological 
      processes disrupted by NTG in a region-specific manner included adaptive and 
      innate immune responses; whereas glutamatergic and dopaminergic synapses and 
      rhythmic process were disrupted in both regions. Regulatory network 
      reconstruction highlighted the widespread role of several transcription factors 
      (including Snrnp70, Smad1, Pax6, Cebpa, and Smpx) among the NTG-disrupted target 
      genes. These results advance the understanding of the molecular mechanisms of 
      hyperalgesia that can be applied to therapies to ameliorate chronic pain and 
      migraine.
FAU - Jeong, Hyeonsoo
AU  - Jeong H
AD  - Department of Animal Sciences, University of Illinois at Urbana-Champaign, 
      Urbana, IL, United States.
FAU - Moye, Laura S
AU  - Moye LS
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States.
FAU - Southey, Bruce R
AU  - Southey BR
AD  - Department of Animal Sciences, University of Illinois at Urbana-Champaign, 
      Urbana, IL, United States.
FAU - Hernandez, Alvaro G
AU  - Hernandez AG
AD  - Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, 
      Urbana, IL, United States.
FAU - Dripps, Isaac
AU  - Dripps I
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States.
FAU - Romanova, Elena V
AU  - Romanova EV
AD  - Department of Chemistry and the Beckman Institute, University of Illinois at 
      Urbana-Champaign, Urbana, IL, United States.
FAU - Rubakhin, Stanislav S
AU  - Rubakhin SS
AD  - Department of Chemistry and the Beckman Institute, University of Illinois at 
      Urbana-Champaign, Urbana, IL, United States.
FAU - Sweedler, Jonathan V
AU  - Sweedler JV
AD  - Department of Chemistry and the Beckman Institute, University of Illinois at 
      Urbana-Champaign, Urbana, IL, United States.
FAU - Pradhan, Amynah A
AU  - Pradhan AA
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United 
      States.
FAU - Rodriguez-Zas, Sandra L
AU  - Rodriguez-Zas SL
AD  - Department of Animal Sciences, University of Illinois at Urbana-Champaign, 
      Urbana, IL, United States.
AD  - Department of Statistics, University of Illinois at Urbana-Champaign, Urbana, IL, 
      United States.
LA  - eng
GR  - P30 DA018310/DA/NIDA NIH HHS/United States
GR  - R01 DA040688/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20181218
PL  - Switzerland
TA  - Front Syst Neurosci
JT  - Frontiers in systems neuroscience
JID - 101477946
PMC - PMC6305622
OTO - NOTNLM
OT  - RNA-seq
OT  - hyperalgesia
OT  - immune response
OT  - migraine
OT  - synapse processes
OT  - transcription factor
OT  - trigeminal ganglia
EDAT- 2019/01/09 06:00
MHDA- 2019/01/09 06:01
PMCR- 2018/01/01
CRDT- 2019/01/09 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/12/03 00:00 [accepted]
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/01/09 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnsys.2018.00063 [doi]
PST - epublish
SO  - Front Syst Neurosci. 2018 Dec 18;12:63. doi: 10.3389/fnsys.2018.00063. 
      eCollection 2018.