PMID- 30619090
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - FSHR Trans-Activation and Oligomerization.
PG  - 760
LID - 10.3389/fendo.2018.00760 [doi]
LID - 760
AB  - Follicle stimulating hormone (FSH) plays a key role in human reproduction 
      through, among others, induction of spermatogenesis in men and production of 
      estrogen in women. The function FSH is performed upon binding to its cognate 
      receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of 
      target cells (granulosa and Sertoli cells). FSHR belongs to the family of G 
      protein-coupled receptors (GPCRs), a family of receptors distinguished by the 
      presence of various signaling pathway activation as well as formation of 
      cross-talking aggregates. Until recently, it was claimed that the FSHR occurred 
      naturally as a monomer, however, the crystal structure as well as experimental 
      evidence have shown that FSHR both self-associates and forms heterodimers with 
      the luteinizing hormone/chorionic gonadotropin receptor-LHCGR. The tremendous 
      gain of knowledge is also visible on the subject of receptor activation. It was 
      once thought that activation occurs only as a result of ligand binding to a 
      particular receptor, however there is mounting evidence of trans-activation as 
      well as biased signaling between GPCRs. Herein, we describe the mechanisms of 
      aforementioned phenomena as well as briefly describe important experiments that 
      contributed to their better understanding.
FAU - Szymanska, Kamila
AU  - Szymanska K
AD  - Department of Biochemistry and Molecular Biology, Medical University of Lublin, 
      Lublin, Poland.
FAU - Kalafut, Joanna
AU  - Kalafut J
AD  - Department of Biochemistry and Molecular Biology, Medical University of Lublin, 
      Lublin, Poland.
FAU - Przybyszewska, Alicja
AU  - Przybyszewska A
AD  - Department of Biochemistry and Molecular Biology, Medical University of Lublin, 
      Lublin, Poland.
FAU - Paziewska, Beata
AU  - Paziewska B
AD  - Department of Biochemistry and Molecular Biology, Medical University of Lublin, 
      Lublin, Poland.
FAU - Adamczuk, Grzegorz
AU  - Adamczuk G
AD  - Independent Medical Biology Unit, Medical University of Lublin, Lublin, Poland.
FAU - Kielbus, Michal
AU  - Kielbus M
AD  - Department of Biochemistry and Molecular Biology, Medical University of Lublin, 
      Lublin, Poland.
FAU - Rivero-Muller, Adolfo
AU  - Rivero-Muller A
AD  - Department of Biochemistry and Molecular Biology, Medical University of Lublin, 
      Lublin, Poland.
AD  - Cell Biology, Biosciences, Faculty of Science and Engineering, Abo Akademi 
      University, Turku, Finland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181213
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6301190
OTO - NOTNLM
OT  - G protein-coupled receptor (GPCR)
OT  - biased signaling
OT  - follicle-stimulating hormone (FSH)
OT  - follicle-stimulating hormone receptor (FSHR)
OT  - heterodimers
OT  - homodimers
OT  - oligomerization
OT  - transactivation
EDAT- 2019/01/09 06:00
MHDA- 2019/01/09 06:01
PMCR- 2018/01/01
CRDT- 2019/01/09 06:00
PHST- 2018/09/26 00:00 [received]
PHST- 2018/11/30 00:00 [accepted]
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/01/09 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00760 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 Dec 13;9:760. doi: 10.3389/fendo.2018.00760. 
      eCollection 2018.