PMID- 30619502
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240506
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 15
DP  - 2018
TI  - An 8-week diet high in cereal fiber and coffee but free of red meat does not 
      improve beta-cell function in patients with type 2 diabetes mellitus: a 
      randomized controlled trial.
PG  - 90
LID - 10.1186/s12986-018-0324-5 [doi]
LID - 90
AB  - BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake 
      is associated with reduced risk for type 2 diabetes in epidemiological studies. 
      We hypothesized that a calorie-restricted diet, which is high in fiber and 
      coffee, but free of red meat, improves beta-cell function in patients with T2D. 
      METHODS: In a randomized parallel-group pilot trial, obese type 2 diabetes 
      patients were randomly allocated to consume either a diet high in cereal fiber 
      and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free 
      of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion 
      was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests 
      (MMTT) before and after dietary intervention. RESULTS: Both diets resulted in 
      comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK 
      -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and 
      blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric 
      inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK 
      only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion 
      after intervention. CONCLUSIONS: Calorie restriction independent of the intake of 
      fiber, coffee or meat failed to improve beta-cell function, but improved GIP 
      secretion in obese patients with type 2 diabetes. TRIAL REGISTRATION: 
      Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 
      August 2011 - Retrospectively registered.
FAU - Karusheva, Yanislava
AU  - Karusheva Y
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
FAU - Kunstein, Lejla
AU  - Kunstein L
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - 3Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, Moorenstr. 5, 40225 Dusseldorf, Germany. ISNI: 
      0000 0001 2176 9917. GRID: grid.411327.2
FAU - Bierwagen, Alessandra
AU  - Bierwagen A
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
FAU - Nowotny, Bettina
AU  - Nowotny B
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
FAU - Kabisch, Stefan
AU  - Kabisch S
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - Department Clinical Nutrition, German Institute for Nutritional Research (DifE) 
      Potsdam, Bergholz-Rehbrucke, Arthur-Scheunert-Allee 114-1, 14558 
      Bergholz-Rehbrucke, Germany.
AD  - 5Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin 
      Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany. GRID: 
      grid.412753.6
FAU - Groener, Jan B
AU  - Groener JB
AD  - 6Department for Internal Medicine I, University Hospital Heidelberg, Im 
      Neuenheimer Feld 410, 69120 Heidelberg, Germany. ISNI: 0000 0001 0328 4908. GRID: 
      grid.5253.1
FAU - Fleitmann, Ann Kristin
AU  - Fleitmann AK
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
FAU - Herder, Christian
AU  - Herder C
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
FAU - Pacini, Giovanni
AU  - Pacini G
AD  - 7Metabolic Unit, Institute of Biomedical Engineering, National Research Council, 
      Corso Stati Uniti, 4, 35127 Padova, Italy. ISNI: 0000 0001 1940 4177. GRID: 
      grid.5326.2
FAU - Strassburger, Klaus
AU  - Strassburger K
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - 8Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz 
      Center for Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm 
      Hennekamp 65, 40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: 
      grid.429051.b
FAU - Haring, Hans-Ulrich
AU  - Haring HU
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - 9Department of Internal Medicine, Division of Endocrinology, Diabetology, 
      Vascular Medicine, Nephrology and Clinical Chemistry and Institute of Diabetes 
      Research and Metabolic Diseases, University Hospital Tubingen, 
      Otfried-Muller-Strasse 10, 72076 Tubingen, Germany. ISNI: 0000 0001 0196 8249. 
      GRID: grid.411544.1
FAU - Nawroth, Peter P
AU  - Nawroth PP
AD  - 6Department for Internal Medicine I, University Hospital Heidelberg, Im 
      Neuenheimer Feld 410, 69120 Heidelberg, Germany. ISNI: 0000 0001 0328 4908. GRID: 
      grid.5253.1
FAU - Pfeiffer, Andreas F H
AU  - Pfeiffer AFH
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - Department Clinical Nutrition, German Institute for Nutritional Research (DifE) 
      Potsdam, Bergholz-Rehbrucke, Arthur-Scheunert-Allee 114-1, 14558 
      Bergholz-Rehbrucke, Germany.
AD  - 5Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin 
      Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany. GRID: 
      grid.412753.6
FAU - Burkart, Volker
AU  - Burkart V
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
FAU - Mussig, Karsten
AU  - Mussig K
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - 3Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, Moorenstr. 5, 40225 Dusseldorf, Germany. ISNI: 
      0000 0001 2176 9917. GRID: grid.411327.2
FAU - Roden, Michael
AU  - Roden M
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - 3Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, Moorenstr. 5, 40225 Dusseldorf, Germany. ISNI: 
      0000 0001 2176 9917. GRID: grid.411327.2
FAU - Szendroedi, Julia
AU  - Szendroedi J
AUID- ORCID: 0000-0002-5185-8168
AD  - 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for 
      Diabetes Research at Heinrich Heine University Dusseldorf, Auf'm Hennekamp 65, 
      40225 Dusseldorf, Germany. ISNI: 0000 0004 0492 602X. GRID: grid.429051.b
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Ingolstadter 
      Landstr. 1, 85764 Neuherberg, Germany.
AD  - 3Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, Moorenstr. 5, 40225 Dusseldorf, Germany. ISNI: 
      0000 0001 2176 9917. GRID: grid.411327.2
LA  - eng
SI  - ClinicalTrials.gov/NCT01409330
PT  - Journal Article
DEP - 20181229
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC6311026
OTO - NOTNLM
OT  - Beta-cell function
OT  - Calorie restriction
OT  - Coffee
OT  - Dietary fiber
OT  - Red meat
COIS- The study was performed according to the Declaration of Helsinki, approved by the 
      ethics committee of the Medical Faculty of Heinrich Heine University Dusseldorf. 
      All participants gave written informed consent before inclusion in the study.All 
      authors have seen and approved the manuscript being submitted.The authors declare 
      that they have no competing interests.Springer Nature remains neutral with regard 
      to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2019/01/09 06:00
MHDA- 2019/01/09 06:01
PMCR- 2018/12/29
CRDT- 2019/01/09 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2018/11/29 00:00 [accepted]
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/01/09 06:01 [medline]
PHST- 2018/12/29 00:00 [pmc-release]
AID - 324 [pii]
AID - 10.1186/s12986-018-0324-5 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2018 Dec 29;15:90. doi: 10.1186/s12986-018-0324-5. eCollection 
      2018.