PMID- 30619504
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1750-9378 (Print)
IS  - 1750-9378 (Electronic)
IS  - 1750-9378 (Linking)
VI  - 13
DP  - 2018
TI  - Association of HLA-G 3' UTR polymorphism and expression with the progression of 
      cervical lesions in human papillomavirus 18 infections.
PG  - 42
LID - 10.1186/s13027-018-0217-2 [doi]
LID - 42
AB  - BACKGROUND: Human leukocyte antigen (HLA)-G is an immune checkpoint molecule, 
      which expression in cervical cancer cells enables them to escape 
      immunosurveillance. To date, limited information has been published on the 
      association of HLA-G genetic background in malignant cells with levels of HLA-G 
      expression and the clinical outcome of patients. METHODS: We investigated the 
      influence of the HLA-G 14 bp In/Del (rs66554220) and + 3142C/G (rs1063320) 
      polymorphisms in 130 cases of HPV16 infection, 130 cases of HPV18 infection and 
      185 age-matched, unrelated, HPV-negative, and cytologically normal Chinese Han 
      women. Case-matched cervical biopsy tissues were evaluated by 
      immunohistochemistry. RESULTS: Our findings show that the frequency of alleles, 
      14 bp In (38.5% vs 29.2%, OR = 1.52, P < 0.05) and + 3142G (72.7% vs 57.0%, 
      OR = 2.01, P < 0.05), were significantly increased in the HPV18-infected group 
      compared with the control group. The HLA-G polymorphisms (alleles 14 bp In 
      and + 3142G) are also associated with the progression of HPV18-related cervical 
      lesions. Moreover, HLA-G expression increased from CIN1 to CIN2/3 lesions and was 
      highest in patients with adenocarcinoma; however, a significant association 
      between these characteristics and the HLA-G polymorphisms was not observed. 
      CONCLUSION: Our results support that the HLA-G 14 bp In and + 3142G alleles are 
      risk factors for HPV18 infections and influence the progression of HPV18-related 
      cervical lesions. This suggests that HLA-G-driven immune mechanisms play an 
      important role in cervical carcinogenesis.
FAU - Xu, Hui-Hui
AU  - Xu HH
AD  - 1Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. GRID: 
      grid.268099.c
AD  - 2Laboratory of Gynecologic Oncology, Taizhou Hospital of Zhejiang Province, 
      Wenzhou Medical University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. 
      GRID: grid.268099.c
FAU - Zhang, Xia
AU  - Zhang X
AD  - 3Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. GRID: 
      grid.268099.c
FAU - Zheng, Hai-Hong
AU  - Zheng HH
AD  - 4Department of Pathology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. GRID: 
      grid.268099.c
FAU - Han, Qiu-Yue
AU  - Han QY
AD  - 3Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. GRID: 
      grid.268099.c
FAU - Lin, Ai-Fen
AU  - Lin AF
AD  - 3Human Tissue Bank, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. GRID: 
      grid.268099.c
FAU - Yan, Wei-Hua
AU  - Yan WH
AUID- ORCID: 0000-0003-1774-7699
AD  - 1Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. GRID: 
      grid.268099.c
AD  - 2Laboratory of Gynecologic Oncology, Taizhou Hospital of Zhejiang Province, 
      Wenzhou Medical University, Linhai, Zhejiang, China. ISNI: 0000 0001 0348 3990. 
      GRID: grid.268099.c
LA  - eng
PT  - Journal Article
DEP - 20181229
PL  - England
TA  - Infect Agent Cancer
JT  - Infectious agents and cancer
JID - 101276559
PMC - PMC6311041
OTO - NOTNLM
OT  - Cervical cancer
OT  - Expression
OT  - Human leukocyte antigen-G
OT  - Human papillomavirus 18
OT  - Polymorphism
OT  - Precancerous cervical lesions
COIS- We all agreed to submit our manuscript "Association of HLA-G 3' UTR polymorphism 
      and expression with the progression of cervical lesions in human papillomavirus 
      18 infections" to Infectious Agents and Cancer. This manuscript has not been 
      submitted to elsewhere.The authors declare no conflict of interests.Springer 
      Nature remains neutral with regard to jurisdictional claims in published maps and 
      institutional affiliations.
EDAT- 2019/01/09 06:00
MHDA- 2019/01/09 06:01
PMCR- 2018/12/29
CRDT- 2019/01/09 06:00
PHST- 2018/10/27 00:00 [received]
PHST- 2018/12/20 00:00 [accepted]
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/01/09 06:01 [medline]
PHST- 2018/12/29 00:00 [pmc-release]
AID - 217 [pii]
AID - 10.1186/s13027-018-0217-2 [doi]
PST - epublish
SO  - Infect Agent Cancer. 2018 Dec 29;13:42. doi: 10.1186/s13027-018-0217-2. 
      eCollection 2018.