PMID- 30620642
OWN - NLM
STAT- MEDLINE
DCOM- 20190813
LR  - 20221207
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Linking)
VI  - 21
IP  - 1
DP  - 2019 Jan
TI  - Use of Continuous Glucose Monitoring Trends to Facilitate Exercise in Children 
      with Type 1 Diabetes.
PG  - 51-55
LID - 10.1089/dia.2018.0292 [doi]
AB  - Diabetes care during exercise frequently requires interruptions to activity and 
      adds extra challenges particularly for young individuals with type 1 diabetes 
      (T1D). This study investigated the use of a carbohydrate (CHO) intake algorithm 
      based on continuous glucose monitoring (CGM) trends during physical activity. 
      Children with T1D diagnosed for >1 year, ages 8-12 years, with a glycated 
      hemoglobin of <10% were recruited into a randomized crossover study. They 
      attended two similar mornings of fun-based physical activity and adhered to 
      either a CHO intake algorithm based on CGM trends (intervention) or to standard 
      exercise guidelines (consumption of 0.5 g CHO/kg/h when glucose <8 mmol/L) 
      (control). Outcome measures included events such as exercise interruptions, CHO 
      intake, and hypoglycemia events and percentage time spent in different sensor 
      glucose ranges. Fourteen children completed the study. No episodes of significant 
      hypoglycemia (sensor glucose level <3.0 mmol/L) occurred in either arm. Mean CHO 
      intake was the same in both arms, 0.3 +/- 0.2 g/kg/h. However, the intervention 
      algorithm resulted in fewer CHO intake events per day: rate [95% confidence 
      interval] 2.4 [1.6-2.3] versus 0.9 [0.4-1.5], P < 0.001, and exercise 
      interruptions: 7.2 [5.9-8.8] versus 1.4 [0.8-2.1], P < 0.001, compared with 
      control. There was no evidence of a difference in percentage time in range 
      (3.9-10 mmol/L) and percentage time spent high between study arms. Both control 
      and intervention protocols prevented significant hypoglycemia. Using a CHO intake 
      algorithm based on CGM trends resulted in fewer CHO intake events and fewer 
      interruptions to exercise. Use of this algorithm may reduce the burden of 
      diabetes management with potential to facilitate activity in young people with 
      T1D.
FAU - Burckhardt, Marie-Anne
AU  - Burckhardt MA
AD  - 1 Children's Diabetes Centre, Telethon Kids Institute, The University of Western 
      Australia, Perth, Australia.
AD  - 2 Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, 
      Western Australia.
AD  - 3 Division of Paediatrics, within the Medical School, The University of Western 
      Australia, Perth, Australia.
FAU - Chetty, Tarini
AU  - Chetty T
AD  - 1 Children's Diabetes Centre, Telethon Kids Institute, The University of Western 
      Australia, Perth, Australia.
AD  - 2 Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, 
      Western Australia.
FAU - Smith, Grant J
AU  - Smith GJ
AD  - 1 Children's Diabetes Centre, Telethon Kids Institute, The University of Western 
      Australia, Perth, Australia.
FAU - Adolfsson, Peter
AU  - Adolfsson P
AD  - 4 Department of Paediatrics, The hospital of Halland, Kungsbacka, Sweden.
AD  - 5 Institute of Clinical Sciences, Sahlgrenska Academy at University of 
      Gothenburg, Gothenburg, Sweden.
FAU - de Bock, Martin
AU  - de Bock M
AD  - 1 Children's Diabetes Centre, Telethon Kids Institute, The University of Western 
      Australia, Perth, Australia.
AD  - 2 Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, 
      Western Australia.
FAU - Jones, Timothy W
AU  - Jones TW
AD  - 1 Children's Diabetes Centre, Telethon Kids Institute, The University of Western 
      Australia, Perth, Australia.
AD  - 2 Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, 
      Western Australia.
AD  - 3 Division of Paediatrics, within the Medical School, The University of Western 
      Australia, Perth, Australia.
FAU - Davis, Elizabeth A
AU  - Davis EA
AD  - 1 Children's Diabetes Centre, Telethon Kids Institute, The University of Western 
      Australia, Perth, Australia.
AD  - 2 Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, 
      Western Australia.
AD  - 3 Division of Paediatrics, within the Medical School, The University of Western 
      Australia, Perth, Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (Blood Glucose)
RN  - 0 (Carbohydrates)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
MH  - *Algorithms
MH  - Blood Glucose/analysis
MH  - Blood Glucose Self-Monitoring/*methods
MH  - Carbohydrates/*analysis
MH  - Child
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 1/blood/*drug therapy/physiopathology
MH  - Exercise/*physiology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hypoglycemia/chemically induced/prevention & control
MH  - Hypoglycemic Agents/administration & dosage
MH  - Male
OTO - NOTNLM
OT  - Carbohydrate intake algorithm.
OT  - Continuous glucose monitoring
OT  - Exercise
OT  - Type 1 diabetes
EDAT- 2019/01/09 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/01/09 06:00
PHST- 2019/01/09 06:00 [entrez]
PHST- 2019/01/09 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
AID - 10.1089/dia.2018.0292 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2019 Jan;21(1):51-55. doi: 10.1089/dia.2018.0292.