PMID- 30622599
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240413
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2018
DP  - 2018
TI  - Spleen-Kidney Supplementing Formula Alleviates Renal Fibrosis in Diabetic Rats 
      via TGF-beta1-miR-21-PTEN Signaling Pathway.
PG  - 3824357
LID - 10.1155/2018/3824357 [doi]
LID - 3824357
AB  - BACKGROUND: Spleen-Kidney Supplementing Formula (SKSF), composed of 6 raw Chinese 
      herbs and proposed based on the therapeutic principle of supplementing 
      spleen-kidney and clearing the extra heat of stomach-lung, is effective in the 
      treatment of type 2 diabetes mellitus (T2DM). AIM: This study aims to investigate 
      the mechanism of SKSF to alleviate renal fibrosis in diabetic rats. METHODS: T2DM 
      model was induced by high-fat diet and multiple injections of low-dose 
      streptozotocin. After 8-week intervention, samples were collected for detection. 
      RESULTS: SKSF decreased fasting blood glucose, glycosylated hemoglobin A1c, blood 
      urea nitrogen, uric acid, urea, 24-hour urine protein, and KW/BW ratio, while it 
      increased creatinine clearance rate of T2DM rats. Meanwhile, SKSF attenuated the 
      renal fibrosis and improved the morphology and structure of renal tissue. 
      Furthermore, SKSF significantly reduced the expression level of plasma miR-21 and 
      TGF-beta1 protein level and increased PTEN protein level. CONCLUSION: SKSF could 
      attenuate the renal damage and renal fibrosis induced in T2DM, which may be 
      related to its regulation on the expressions of TGF-beta1, PTEN, and miR-21.
FAU - Tian, Chunyu
AU  - Tian C
AUID- ORCID: 0000-0001-6234-9388
AD  - Traditional Chinese Medical College, North China University of Science and 
      Technology, Tangshan 063210, China.
FAU - Wang, Ya
AU  - Wang Y
AUID- ORCID: 0000-0002-0781-9057
AD  - Traditional Chinese Medical College, North China University of Science and 
      Technology, Tangshan 063210, China.
FAU - Chang, Hong
AU  - Chang H
AUID- ORCID: 0000-0002-6926-8895
AD  - Traditional Chinese Medical College, North China University of Science and 
      Technology, Tangshan 063210, China.
FAU - Li, Ji'an
AU  - Li J
AUID- ORCID: 0000-0003-2094-5610
AD  - Traditional Chinese Medical College, North China University of Science and 
      Technology, Tangshan 063210, China.
FAU - La, Xiaojin
AU  - La X
AD  - Traditional Chinese Medical College, North China University of Science and 
      Technology, Tangshan 063210, China.
LA  - eng
PT  - Journal Article
DEP - 20181206
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC6304600
EDAT- 2019/01/10 06:00
MHDA- 2019/01/10 06:01
PMCR- 2018/12/06
CRDT- 2019/01/10 06:00
PHST- 2018/09/30 00:00 [received]
PHST- 2018/11/28 00:00 [accepted]
PHST- 2019/01/10 06:00 [entrez]
PHST- 2019/01/10 06:00 [pubmed]
PHST- 2019/01/10 06:01 [medline]
PHST- 2018/12/06 00:00 [pmc-release]
AID - 10.1155/2018/3824357 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2018 Dec 6;2018:3824357. doi: 
      10.1155/2018/3824357. eCollection 2018.