PMID- 30623538
OWN - NLM
STAT- MEDLINE
DCOM- 20190628
LR  - 20190628
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 19
IP  - 3
DP  - 2019 Mar
TI  - Citrullinated histone H3 expression in anti-neutrophil cytoplasmic 
      antibody-associated vasculitis in older Japanese autopsy patients.
PG  - 259-264
LID - 10.1111/ggi.13596 [doi]
AB  - AIM: Neutrophil extracellular traps play key roles in the necrotizing vasculitis 
      associated with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). 
      However, the relationships between neutrophil extracellular traps formation and 
      the distribution and phase of vasculitis are not well understood. In the present 
      study, we clarified the clinicopathological characteristics of older AAV 
      patients, as well as the expression of citrullinated histone H3 (citH3), a marker 
      of neutrophil extracellular traps, in autopsied AAV patients. METHODS: We 
      reviewed autopsy cases that were carried out at Tokyo Metropolitan Geriatric 
      Hospital, Tokyo, Japan, from 2001 to 2018. The expression of citH3 was determined 
      by immunostaining. RESULTS: AAV patients (six cases) were elderly (aged 73-94 
      years; three men and three women; myeloperoxidase anti-neutrophil cytoplasmic 
      antibody-positive, five cases; proteinase-3 anti-neutrophil cytoplasmic 
      antibody-positive, one case; disease duration was 1.5-5.5 months; and patients 
      were treated with steroids. All patients had necrotizing vasculitis in the 
      medium-to-small-sized vessels in various organs, and also severe 
      vasculitis-associated lesions including brain hemorrhage, alveolar bleeding, 
      interstitial pneumonia, crescentic nephritis, acute pancreatitis and 
      gastrointestinal bleeding. Expression of citH3 was associated with the activity 
      of inflammation. CONCLUSIONS: We report severe clinicopathological 
      characteristics of AAV in older patients. Expression of citH3 was a useful marker 
      to evaluate vasculitis severity. Identification of these features might aid in 
      the diagnosis of AAV. Geriatr Gerontol Int 2019; 19: 259-264.
CI  - (c) 2019 Japan Geriatrics Society.
FAU - Matsuda, Yoko
AU  - Matsuda Y
AUID- ORCID: 0000-0002-3235-655X
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Itabashi, Mitsuyo
AU  - Itabashi M
AD  - Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Tachibana, Yasuko
AU  - Tachibana Y
AD  - Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Sugihara, Takahiko
AU  - Sugihara T
AD  - Department of Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Sakashita, Yasuhiro
AU  - Sakashita Y
AD  - Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan 
      Geriatric Hospital & Institute of Gerontology, Tokyo, Japan.
FAU - Matsubara, Tomoyasu
AU  - Matsubara T
AD  - Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan 
      Geriatric Hospital & Institute of Gerontology, Tokyo, Japan.
FAU - Murayama, Shigeo
AU  - Murayama S
AD  - Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan 
      Geriatric Hospital & Institute of Gerontology, Tokyo, Japan.
FAU - Yumura, Wako
AU  - Yumura W
AD  - Department of Nephrology, Preventive Medical Center, International University of 
      Health Welfare Hospital, Tochigi, Japan.
FAU - Shimizu, Akira
AU  - Shimizu A
AD  - Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
FAU - Takei, Takashi
AU  - Takei T
AD  - Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Arai, Tomio
AU  - Arai T
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190108
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
RN  - 0 (Histones)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*metabolism/mortality/*pathology
MH  - Autopsy
MH  - *Citrullination
MH  - Female
MH  - Histones/*metabolism
MH  - Humans
MH  - Japan
MH  - Male
MH  - Retrospective Studies
OTO - NOTNLM
OT  - anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - autopsy
OT  - citrullinated histone H3
OT  - elderly
EDAT- 2019/01/10 06:00
MHDA- 2019/06/30 06:00
CRDT- 2019/01/10 06:00
PHST- 2018/09/21 00:00 [received]
PHST- 2018/10/31 00:00 [revised]
PHST- 2018/11/30 00:00 [accepted]
PHST- 2019/01/10 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2019/01/10 06:00 [entrez]
AID - 10.1111/ggi.13596 [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2019 Mar;19(3):259-264. doi: 10.1111/ggi.13596. Epub 2019 
      Jan 8.