PMID- 30623897
OWN - NLM
STAT- MEDLINE
DCOM- 20190807
LR  - 20200225
IS  - 1827-675X (Electronic)
IS  - 0392-100X (Print)
IS  - 0392-100X (Linking)
VI  - 38
IP  - 6
DP  - 2018 Dec
TI  - Clinical characteristics of patients with granulomatosis with polyangiitis and 
      microscopic polyangiitis in ENT practice: a comparative analysis.
PG  - 517-527
LID - 10.14639/0392-100X-1776 [doi]
AB  - ENT manifestations are commonly observed in patients with small vessel vasculitis 
      (SVV). The main aim of this study was to analyse and present the 
      clinicopathological characteristics of individuals with SVV emphasising 
      otorhinolaryngological symptoms. This study evaluated 64 patients, 41 with 
      granulomatosis with polyangiitis (GPA) and 23 with microscopic polyangiitis 
      (MPA). Herein, we compare the clinicopathologic features of GPA and MPA. The 
      average age at diagnosis was 50.2 and 56.2 years, for GPA and MPA, respectively. 
      57 patients (89%) were antineutrophil cytoplasmic antibody (ANCA) positive, 34 
      (59.6%) for anti-proteinase 3 (PR3)-ANCA and 21 (36.8%) for myeloperoxidase 
      (MPO)-ANCA. 7 patients (10.9%) were ANCA negative. The most commonly affected 
      organs were lungs (76.56%), ear, nose, throat (ENT) (75%) and kidneys (73.44%). 
      ENT disorders mainly appeared as chronic rhinosinusitis and epistaxis and 
      preceded SVV diagnosis by an average 14.4 months. In the majority of patients, 
      ENT disorders were the first symptoms of SVV and preceded its systemic 
      transformation. Pulmonary, ENT and nervous manifestations were more common in 
      GPA, whereas the prevalence of renal, gastrointestinal, cutaneous, cardiovascular 
      and ocular disorders was higher in MPA. The results of our study emphasise the 
      high prevalence of ENT symptoms in patients with SVV, especially in those with 
      GPA. We highlight the significant role of the otorhinolaryngologist in early SVV 
      diagnosis and management. Any patient with persistent ENT symptoms or ENT 
      dysfunctions not responding to standard otorhinolaryngological treatment should 
      be precisely and rapidly evaluated for the presence of systemic dysfunctions 
      (especially renal and pulmonary). Realising the differences and similarities 
      between GPA and MPA is crucial in undelayed SVV diagnosis and proper treatment.
CI  - Copyright (c) 2018 Societa Italiana di Otorinolaringoiatria e Chirurgia 
      Cervico-Facciale, Rome, Italy.
FAU - Wojciechowska, J
AU  - Wojciechowska J
AD  - Department and Clinic of Otolaryngology, Head and Neck Surgery, Wroclaw Medical 
      University Hospital, Borowska, Poland.
FAU - KreCicki, T
AU  - KreCicki T
AD  - Department and Clinic of Otolaryngology, Head and Neck Surgery, Wroclaw Medical 
      University Hospital, Borowska, Poland.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - Acta Otorhinolaryngol Ital
JT  - Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di 
      otorinolaringologia e chirurgia cervico-facciale
JID - 8213019
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Granulomatosis with Polyangiitis/complications/*diagnosis
MH  - Humans
MH  - Male
MH  - Microscopic Polyangiitis/complications/*diagnosis
MH  - Middle Aged
MH  - Otorhinolaryngologic Diseases/etiology
MH  - Young Adult
PMC - PMC6325653
OTO - NOTNLM
OT  - Granulomatosis with polyangiitis
OT  - MPO-ANCA
OT  - Microscopic polyangiitis
OT  - PR3-ANCA
OT  - Vasculitis
EDAT- 2019/01/10 06:00
MHDA- 2019/08/08 06:00
PMCR- 2018/12/01
CRDT- 2019/01/10 06:00
PHST- 2017/05/22 00:00 [received]
PHST- 2017/09/24 00:00 [accepted]
PHST- 2019/01/10 06:00 [entrez]
PHST- 2019/01/10 06:00 [pubmed]
PHST- 2019/08/08 06:00 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.14639/0392-100X-1776 [doi]
PST - ppublish
SO  - Acta Otorhinolaryngol Ital. 2018 Dec;38(6):517-527. doi: 10.14639/0392-100X-1776.