PMID- 30626079 OWN - NLM STAT- MEDLINE DCOM- 20190426 LR - 20200225 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 20 IP - 1 DP - 2019 Jan 8 TI - Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy. LID - 10.3390/ijms20010214 [doi] LID - 214 AB - Relapse remains a major obstacle to the survival of patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation. A disintegrin-like and metalloprotease with a thrombospondin type 1 motif (ADMATS13), which cleaves von Willebrand factor multimers into less active fragments, is encoded by the ADAMTS13 gene and has a functional single-nucleotide polymorphism (SNP) rs2285489 (C > T). We retrospectively examined whether ADAMTS13 rs2285489 affected the transplant outcomes in a cohort of 281 patients who underwent unrelated human leukocyte antigen (HLA)-matched bone marrow transplantation for hematologic malignancies. The recipient ADAMTS13 C/C genotype, which putatively has low inducibility, was associated with an increased relapse rate (hazard ratio [HR], 3.12; 95% confidence interval [CI], 1.25(-)7.77; P = 0.015), resulting in a lower disease-free survival rate in the patients with a recipient C/C genotype (HR, 1.64; 95% CI, 1.01(-)2.67; P = 0.045). Therefore, ADAMTS13 rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks. FAU - Nomoto, Haruka AU - Nomoto H AD - Department of Clinical Laboratory Science, Kanazawa University School of Medical Sciences, Kanazawa 920-0942, Japan. haruka84@stu.kanazawa-u.ac.jp. FAU - Takami, Akiyoshi AU - Takami A AUID- ORCID: 0000-0002-1822-9976 AD - Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan. takami-knz@umin.ac.jp. AD - Hematopoietic Cell Transplantation Center, Aichi Medical University Hospital, Nagakute 480-1195, Japan. takami-knz@umin.ac.jp. FAU - Espinoza, J Luis AU - Espinoza JL AUID- ORCID: 0000-0002-1794-6666 AD - Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan. luis1.esp2.cd@outlook.com. FAU - Onizuka, Makoto AU - Onizuka M AD - Department of Hematology and Oncology, Tokai University School of Medicine, Isehara 259-1193, Japan. moni5@mac.com. FAU - Kashiwase, Koichi AU - Kashiwase K AD - Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo 135-8521, Japan. k-kashiwase@ktks.bbc.jrc.or.jp. FAU - Morishima, Yasuo AU - Morishima Y AD - Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan. ymorisim@aichi-cc.jp. FAU - Fukuda, Takahiro AU - Fukuda T AD - Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo 104-0045, Japan. tafukuda@ncc.go.jp. FAU - Kodera, Yoshihisa AU - Kodera Y AD - Hematopoietic Cell Transplantation Center, Aichi Medical University Hospital, Nagakute 480-1195, Japan. ykodera@river.ocn.ne.jp. FAU - Doki, Noriko AU - Doki N AD - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan. n-doki@cick.jp. FAU - Miyamura, Koichi AU - Miyamura K AD - Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya 453-8511, Japan. miyamu@nagoya-1st.jrc.or.jp. FAU - Mori, Takehiko AU - Mori T AD - Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan. tmori@a3.keio.jp. FAU - Nakao, Shinji AU - Nakao S AD - Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8641, Japan. snakao8205@staff.kanazawa-u.ac.jp. FAU - Morishita, Eriko AU - Morishita E AUID- ORCID: 0000-0001-9116-3363 AD - Department of Clinical Laboratory Science, Kanazawa University School of Medical Sciences, Kanazawa 920-0942, Japan. eriko86@staff.kanazawa-u.ac.jp. LA - eng GR - 15K09513/The Ministry of Education, Culture, Sports and Technology of Japan/ GR - 16769214/The Ministry of Health, Labour and Welfare of Japan/ PT - Journal Article DEP - 20190108 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - EC 3.4.24.87 (ADAMTS13 Protein) RN - EC 3.4.24.87 (ADAMTS13 protein, human) SB - IM MH - ADAMTS13 Protein/*genetics MH - Adolescent MH - Adult MH - Aged MH - *Bone Marrow Transplantation MH - Child MH - Child, Preschool MH - Disease-Free Survival MH - Female MH - Hematologic Neoplasms/*genetics/*therapy MH - Humans MH - Infant MH - Kaplan-Meier Estimate MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Polymorphism, Single Nucleotide/*genetics MH - Recurrence MH - *Transplant Recipients MH - Treatment Outcome MH - Young Adult PMC - PMC6337246 OTO - NOTNLM OT - ADAMTS13 OT - bone marrow transplantation OT - single nucleotide polymorphism OT - unrelated donor COIS- The authors declare no competing financial interests. EDAT- 2019/01/11 06:00 MHDA- 2019/04/27 06:00 PMCR- 2019/01/01 CRDT- 2019/01/11 06:00 PHST- 2018/12/08 00:00 [received] PHST- 2019/01/02 00:00 [revised] PHST- 2019/01/04 00:00 [accepted] PHST- 2019/01/11 06:00 [entrez] PHST- 2019/01/11 06:00 [pubmed] PHST- 2019/04/27 06:00 [medline] PHST- 2019/01/01 00:00 [pmc-release] AID - ijms20010214 [pii] AID - ijms-20-00214 [pii] AID - 10.3390/ijms20010214 [doi] PST - epublish SO - Int J Mol Sci. 2019 Jan 8;20(1):214. doi: 10.3390/ijms20010214.