PMID- 30626094
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2079-4983 (Print)
IS  - 2079-4983 (Electronic)
IS  - 2079-4983 (Linking)
VI  - 10
IP  - 1
DP  - 2019 Jan 8
TI  - Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and 
      Neurodegenerative Disorder Therapies.
LID - 10.3390/jfb10010004 [doi]
LID - 4
AB  - Polymer nanoparticles (NPs) represent one of the most innovative non-invasive 
      approaches for drug delivery applications. NPs main objective is to convey the 
      therapeutic molecule be they drugs, proteins, or nucleic acids directly into the 
      target organ or tissue. Many polymers are used for the synthesis of NPs and among 
      the currently most employed materials several biocompatible synthetic polymers, 
      namely polylactic acid (PLA), poly lactic-co-glycolic acid (PLGA), and 
      polyethylene glycol (PEG), can be cited. These molecules are made of simple 
      monomers which are naturally present in the body and therefore easily excreted 
      without being toxic. The present review addresses the different approaches that 
      are most commonly adopted to synthetize biocompatible NPs to date, as well as the 
      experimental strategies designed to load them with therapeutic agents. In fact, 
      drugs may be internalized in the NPs or physically dispersed therein. In this 
      paper the various types of biodegradable polymer NPs will be discussed with 
      emphasis on their applications in drug delivery. Close attention will be devoted 
      to the treatment of cancer, where both active and passive targeting is used to 
      enhance efficacy and reduce systemic toxicity, and to diseases affecting the 
      central nervous system, inasmuch as NPs can be modified to target specific cells 
      or cross membrane barriers.
FAU - Calzoni, Eleonora
AU  - Calzoni E
AD  - Department of Chemistry, Biology and Biotechnology, Biochemistry and Molecular 
      Biology Section, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. 
      eleonoracalzoni@gmail.com.
AD  - Centro di Eccellenza su Materiali Innovativi Nanostrutturati (CEMIN), University 
      of Perugia, Via del Giochetto, 06123 Perugia, Italy. eleonoracalzoni@gmail.com.
FAU - Cesaretti, Alessio
AU  - Cesaretti A
AUID- ORCID: 0000-0001-5814-8524
AD  - Department of Chemistry, Biology and Biotechnology, Biochemistry and Molecular 
      Biology Section, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. 
      alex.cesaretti14@gmail.com.
AD  - Centro di Eccellenza su Materiali Innovativi Nanostrutturati (CEMIN), University 
      of Perugia, Via del Giochetto, 06123 Perugia, Italy. alex.cesaretti14@gmail.com.
FAU - Polchi, Alice
AU  - Polchi A
AD  - Department of Chemistry, Biology and Biotechnology, Biochemistry and Molecular 
      Biology Section, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. 
      alicepolchi@virgilio.it.
AD  - Centro di Eccellenza su Materiali Innovativi Nanostrutturati (CEMIN), University 
      of Perugia, Via del Giochetto, 06123 Perugia, Italy. alicepolchi@virgilio.it.
FAU - Di Michele, Alessandro
AU  - Di Michele A
AUID- ORCID: 0000-0002-0357-2608
AD  - Department of Physics and Geology, University of Perugia, via Pascoli, 06123 
      Perugia, Italy. alessandro.dimichele@unipg.it.
FAU - Tancini, Brunella
AU  - Tancini B
AD  - Department of Chemistry, Biology and Biotechnology, Biochemistry and Molecular 
      Biology Section, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. 
      brunella.tancini@unipg.it.
AD  - Centro di Eccellenza su Materiali Innovativi Nanostrutturati (CEMIN), University 
      of Perugia, Via del Giochetto, 06123 Perugia, Italy. brunella.tancini@unipg.it.
FAU - Emiliani, Carla
AU  - Emiliani C
AD  - Department of Chemistry, Biology and Biotechnology, Biochemistry and Molecular 
      Biology Section, University of Perugia, Via del Giochetto, 06123 Perugia, Italy. 
      carla.emiliani@unipg.it.
AD  - Centro di Eccellenza su Materiali Innovativi Nanostrutturati (CEMIN), University 
      of Perugia, Via del Giochetto, 06123 Perugia, Italy. carla.emiliani@unipg.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190108
PL  - Switzerland
TA  - J Funct Biomater
JT  - Journal of functional biomaterials
JID - 101570734
PMC - PMC6463038
OTO - NOTNLM
OT  - cancer therapy
OT  - drug delivery
OT  - nanoparticles
OT  - neurodegenerative disease therapy
OT  - polymers
COIS- The authors declare no conflict of interest.
EDAT- 2019/01/11 06:00
MHDA- 2019/01/11 06:01
PMCR- 2019/03/01
CRDT- 2019/01/11 06:00
PHST- 2018/10/31 00:00 [received]
PHST- 2018/12/20 00:00 [revised]
PHST- 2018/12/28 00:00 [accepted]
PHST- 2019/01/11 06:00 [entrez]
PHST- 2019/01/11 06:00 [pubmed]
PHST- 2019/01/11 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - jfb10010004 [pii]
AID - jfb-10-00004 [pii]
AID - 10.3390/jfb10010004 [doi]
PST - epublish
SO  - J Funct Biomater. 2019 Jan 8;10(1):4. doi: 10.3390/jfb10010004.