PMID- 30626391 OWN - NLM STAT- MEDLINE DCOM- 20190213 LR - 20200309 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 18 IP - 1 DP - 2019 Jan 9 TI - Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy. PG - 5 LID - 10.1186/s12940-018-0445-3 [doi] LID - 5 AB - BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt endocrine system and reproduction. However, epidemiological evidence on the association between PFAS and preeclampsia is inconsistent. We aimed to investigate the association between prenatal PFAS exposure and hypertensive disorders of pregnancy (HDP) in humans. METHODS: PFAS were measured by liquid chromatography system coupled with tandem mass spectrometry in 687 umbilical cord plasma samples collected between 2011 and 2012 in Shanghai, China. Information on HDP including gestational hypertension and preeclampsia was abstracted from medical records. Multiple logistic regression was used to examine the association of each PFAS with gestational hypertension, preeclampsia, and overall HDP in separate models. Elastic net regression with logit link was used to identify independent associations between exposures and outcomes. Logistic regression was used to obtain the unpenalized estimates of the selected PFAS components for the associations with outcomes, adjusting for age, education level, pre-pregnancy BMI, parity, and mutual adjustment of selected PFAS. RESULTS: The risk of gestational hypertension and preeclampsia was 3.3% and 2.8% in our subjects, respectively. Perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), perfluoroundecanoic acid (PFUA) were associated with preeclampsia based on elastic net penalty regression. In the fully adjusted statistical model, women with a higher level of standardized ln-transformed PFBS had an increased odds of preeclampsia [adjusted odds ratio (AOR): 1.81, 95% confidence interval (CI): 1.03-3.17], and overall HDP (AOR: 1.64, 95% CI: 1.09-2.47). CONCLUSIONS: Prenatal exposure to PFBS was positively associated with the risk of preeclampsia and overall HDP. FAU - Huang, Rong AU - Huang R AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. FAU - Chen, Qian AU - Chen Q AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. FAU - Zhang, Lin AU - Zhang L AD - Department of Obstetrics and Gynecology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, China. FAU - Luo, Kai AU - Luo K AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. AD - School of Public Health, Shanghai Jiao Tong University, 227 S. Chongqing Road, Shanghai, China. FAU - Chen, Lin AU - Chen L AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. FAU - Zhao, Shasha AU - Zhao S AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. FAU - Feng, Liping AU - Feng L AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. AD - Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, 27710, USA. FAU - Zhang, Jun AU - Zhang J AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. junjimzhang@sina.com. AD - School of Public Health, Shanghai Jiao Tong University, 227 S. Chongqing Road, Shanghai, China. junjimzhang@sina.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190109 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fatty Acids) RN - 0 (Fluorocarbons) SB - IM MH - Adult MH - Alkanesulfonic Acids/*blood MH - China MH - Environmental Monitoring MH - Environmental Pollutants/*blood MH - Fatty Acids/*blood MH - Female MH - Fetal Blood/*chemistry MH - Fluorocarbons/*blood MH - Humans MH - Hypertension, Pregnancy-Induced/*epidemiology MH - *Maternal Exposure MH - Pregnancy MH - Risk PMC - PMC6327470 OTO - NOTNLM OT - Cord blood OT - Gestational hypertension OT - PFAS OT - Preeclampsia COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The ethics approval was obtained from the Xinhua Hospital and International Peace Maternity and Infant Health affiliated to the Shanghai Jiao Tong University School of Medicine. This study was conducted in accordance with the principles of the Helsinki Declaration. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2019/01/11 06:00 MHDA- 2019/02/14 06:00 PMCR- 2019/01/09 CRDT- 2019/01/11 06:00 PHST- 2018/06/15 00:00 [received] PHST- 2018/12/28 00:00 [accepted] PHST- 2019/01/11 06:00 [entrez] PHST- 2019/01/11 06:00 [pubmed] PHST- 2019/02/14 06:00 [medline] PHST- 2019/01/09 00:00 [pmc-release] AID - 10.1186/s12940-018-0445-3 [pii] AID - 445 [pii] AID - 10.1186/s12940-018-0445-3 [doi] PST - epublish SO - Environ Health. 2019 Jan 9;18(1):5. doi: 10.1186/s12940-018-0445-3.