PMID- 30627176
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1735-0344 (Print)
IS  - 2345-3729 (Electronic)
IS  - 1735-0344 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Feb
TI  - Immunologic Role of Extracellular Vesicles and Exosomes in the Pathogenesis of 
      Cystic Fibrosis.
PG  - 66-72
AB  - Cystic Fibrosis (CF) is the most common lethal autosomal recessive disease that 
      affects many organs including, lung, pancreas and liver. Cystic fibrosis is a 
      monogenic disease and occurs in the white Caucasians. Massive neutrophil 
      granulocyte influx in the airways is one of the characteristics of CF. 
      Extracellular Vesicles (EVs), microvesicles, and exosomes are vesicles released 
      from cells into extracellular space of the body and are able to influence other 
      cells by different methods. They have an important role in the intracellular 
      communication by transferring information between donor and recipients cells. 
      Granulocytes are known as the main source of microparticles in the CF patients. 
      Microparticles derived from neutrophils are associated with the extensive 
      neutrophil influx into airways and aggregation at the epithelial surface of the 
      CF patient's respiratory tract. Exosomes are found in almost all body fluids, 
      such as urine, sputum, Bronchoalveolar Lavage (BAL), milk, Cerebrospinal Fluid 
      (CSF), plasma and sputum. Examination of exosomes derived from CF patients may be 
      helpful in the characterization of pathogenesis of disease in detail. In this 
      mini review, we have summarized the role of microparticles and exosomes in 
      pathogenesis of CF and finally discussed the feasibility of this particle in 
      treatment approaches.
FAU - Asef, Alireza
AU  - Asef A
AD  - Department of Biology. Islamic Azad University, Rasht Branch, Rasht, Iran.
FAU - Mortaz, Esmaeil
AU  - Mortaz E
AD  - Department of Immunology, Faculty of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
AD  - Clinical Tuberculosis and Epidemiology Research Center, National Research and 
      Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Jamaati, Hamidreza
AU  - Jamaati H
AD  - Chronic Respiratory Disease Research Center, NRITLD, Shahid Beheshti University 
      of Medical Sciences, Tehran- Iran.
FAU - Velayati, Aliakbar
AU  - Velayati A
AD  - Pediatric Respiratory Disease Research Center, NRITLD, Shahid Beheshti University 
      of Medical Sciences, Tehran- Iran.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Iran
TA  - Tanaffos
JT  - Tanaffos
JID - 101308232
PMC - PMC6320567
OTO - NOTNLM
OT  - Exosomes
OT  - Lung cystic fibrosis
OT  - Microparticles
OT  - sputum
EDAT- 2019/01/11 06:00
MHDA- 2019/01/11 06:01
PMCR- 2018/02/01
CRDT- 2019/01/11 06:00
PHST- 2019/01/11 06:00 [entrez]
PHST- 2019/01/11 06:00 [pubmed]
PHST- 2019/01/11 06:01 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - tanaffos-17-66 [pii]
PST - ppublish
SO  - Tanaffos. 2018 Feb;17(2):66-72.