PMID- 30627372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 21
IP  - 12
DP  - 2018 Dec
TI  - Involvement of central opiate receptors in modulation of centrally administered 
      oxytocin-induced antinociception.
PG  - 1275-1280
LID - 10.22038/ijbms.2018.26302.6449 [doi]
AB  - OBJECTIVES: Oxytocin is involved in modulation of many brain-mediated functions. 
      In the present study, we investigated the central effects of oxytocin and its 
      receptor antagonist, atosiban on inflammatory pain. The contribution of opiate 
      receptors was explored using non-selective and selective antagonists. MATERIALS 
      AND METHODS: The fourth ventricle of the brain of anesthetized rats was implanted 
      with a guide cannula. Inflammatory pain in the orofacial region was induced by 
      subcutaneous (SC) injection of formalin into the vibrissa pad, and time duration 
      of face rubbing behavior was measured for 45 min. RESULTS: A typical biphasic 
      pain was observed after formalin injection. This biphasic pain behavior was 
      attenuated by intra-fourth ventricle administration of oxytocin (12.5, 50, and 
      200 ng/rat). Central prior administration of 400 ng/rat atosiban (an oxytocin 
      receptor antagonist), naloxone (a non-selective opiate receptor antagonist), 
      naloxonazine (a selective micro-opiate receptor antagonist), and nor-binaltorphimine 
      (a selective kappa-opiate receptor antagonist), but not naltrindole (a delta-opiate 
      receptor antagonist), prevented oxytocin-induced (200 ng/rat) antinociception. 
      Except for naltrindole, other antagonists increased pain intensity when used 
      alone. Above-mentioned drugs did not alter locomotor activity. CONCLUSION: 
      Oxytocin, as a neuropeptide neurotransmitter, may be involved in the supraspinal 
      modulation of inflammatory pain through micro- and kappa-, but not delta-opiate receptors.
FAU - Erfanparast, Amir
AU  - Erfanparast A
AD  - Division of Physiology, Department of Basic Sciences, Faculty of Veterinary 
      Medicine, Urmia University, Urmia, Iran.
FAU - Tamaddonfard, Esmaeal
AU  - Tamaddonfard E
AD  - Division of Physiology, Department of Basic Sciences, Faculty of Veterinary 
      Medicine, Urmia University, Urmia, Iran.
FAU - Seyedin, Sahar
AU  - Seyedin S
AD  - Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC6312677
OTO - NOTNLM
OT  - Fourth ventricle
OT  - Opioid receptors
OT  - Orofacial pain
OT  - Oxytocin
OT  - Rats
COIS- The authors have no conflict of interest to declare.
EDAT- 2019/01/11 06:00
MHDA- 2019/01/11 06:01
PMCR- 2018/12/01
CRDT- 2019/01/11 06:00
PHST- 2019/01/11 06:00 [entrez]
PHST- 2019/01/11 06:00 [pubmed]
PHST- 2019/01/11 06:01 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.22038/ijbms.2018.26302.6449 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2018 Dec;21(12):1275-1280. doi: 
      10.22038/ijbms.2018.26302.6449.