PMID- 30628778
OWN - NLM
STAT- MEDLINE
DCOM- 20190604
LR  - 20190604
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 11
IP  - 5
DP  - 2019 Feb 6
TI  - Protection of Nanostructures-Integrated Microneedle Biosensor Using Dissolvable 
      Polymer Coating.
PG  - 4809-4819
LID - 10.1021/acsami.8b18981 [doi]
AB  - Real-time transdermal biosensing provides a direct route to quantify biomarkers 
      or physiological signals of local tissues. Although microneedles (MNs) present a 
      mini-invasive transdermal technique, integration of MNs with advanced 
      nanostructures to enhance sensing functionalities has rarely been achieved. This 
      is largely due to the fact that nanostructures present on MNs surface could be 
      easily destructed due to friction during skin insertion. In this work, we 
      reported a dissolvable polymer-coating technique to protect 
      nanostructures-integrated MNs from mechanical destruction during MNs insertion. 
      After penetration into the skin, the polymer could readily dissolve by 
      interstitial fluids so that the superficial nanostructures on MNs could be 
      re-exposed for sensing purpose. To demonstrate this technique, metallic and resin 
      MNs decorated with vertical ZnO nanowires (vNWs) were employed as an example. 
      Dissolvable poly(vinyl pyrrolidone) was spray-coated on the vNW-MNs surface as a 
      protective layer, which effectively protected the superficial ZnO NWs when MNs 
      penetrated the skin. Transdermal biosensing of H(2)O(2) biomarker in skin tissue 
      using the polymer-protecting MNs sensor was demonstrated both ex vivo and in 
      vivo. The results indicated that polymer coating successfully preserved the 
      sensing functionalities of the MNs sensor after inserting into the skin, whereas 
      the sensitivity of the MN sensor without a coating protection was significantly 
      compromised by 3-folds. This work provided unique opportunities of protecting 
      functional nanomodulus on MNs surface for minimally invasive transdermal 
      biosensing.
FAU - Liu, Fanmao
AU  - Liu F
AUID- ORCID: 0000-0001-7590-8062
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital , 
      Sun Yat-sen University , 510080 Guangzhou , China.
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Lin, Zhihong
AU  - Lin Z
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Jin, Quanchang
AU  - Jin Q
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Wu, Qianni
AU  - Wu Q
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center , Sun Yat-sen 
      University , 510060 Guangzhou , China.
FAU - Yang, Chengduan
AU  - Yang C
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital , 
      Sun Yat-sen University , 510080 Guangzhou , China.
FAU - Chen, Hui-Jiuan
AU  - Chen HJ
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Cao, Zihan
AU  - Cao Z
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Lin, Di-An
AU  - Lin DA
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Zhou, Lingfei
AU  - Zhou L
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Hang, Tian
AU  - Hang T
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - He, Gen
AU  - He G
AUID- ORCID: 0000-0003-1394-0053
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
FAU - Xu, Yonghang
AU  - Xu Y
AD  - School of Materials Science and Energy Engineering , Foshan University , 528000 
      Foshan , China.
FAU - Xia, Wenhao
AU  - Xia W
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital , 
      Sun Yat-sen University , 510080 Guangzhou , China.
FAU - Tao, Jun
AU  - Tao J
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital , 
      Sun Yat-sen University , 510080 Guangzhou , China.
FAU - Xie, Xi
AU  - Xie X
AUID- ORCID: 0000-0001-7406-8444
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital , 
      Sun Yat-sen University , 510080 Guangzhou , China.
AD  - State Key Laboratory of Optoelectronic Materials and Technologies, School of 
      Electronics and Information Technology , Sun Yat-sen University , 510006 
      Guangzhou , China.
LA  - eng
PT  - Journal Article
DEP - 20190124
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - FZ989GH94E (Povidone)
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - Animals
MH  - Biosensing Techniques/*instrumentation
MH  - Equipment Design
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microinjections/*instrumentation
MH  - Models, Biological
MH  - Nanowires/*chemistry
MH  - *Needles
MH  - Povidone/chemistry
MH  - Skin/chemistry
MH  - Swine
MH  - Zinc Oxide/chemistry
OTO - NOTNLM
OT  - biosensing
OT  - dissolvable polymer coating
OT  - microneedle
OT  - nanostructure
OT  - transdermal biosensing
EDAT- 2019/01/11 06:00
MHDA- 2019/06/05 06:00
CRDT- 2019/01/11 06:00
PHST- 2019/01/11 06:00 [pubmed]
PHST- 2019/06/05 06:00 [medline]
PHST- 2019/01/11 06:00 [entrez]
AID - 10.1021/acsami.8b18981 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2019 Feb 6;11(5):4809-4819. doi: 
      10.1021/acsami.8b18981. Epub 2019 Jan 24.