PMID- 30629141 OWN - NLM STAT- MEDLINE DCOM- 20201005 LR - 20201005 IS - 2047-2412 (Electronic) IS - 2047-2404 (Linking) VI - 20 IP - 7 DP - 2019 Jul 1 TI - Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus. PG - 816-827 LID - 10.1093/ehjci/jey217 [doi] AB - AIMS: Few prospective studies have evaluated the natural progression of left ventricular (LV) remodelling in patients with Type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the impact of obesity on longitudinal cardiac structural and functional changes in patients with T2DM. METHODS AND RESULTS: This study comprised of 274 patients with T2DM (mean age, 62.2 +/- 11.4 years; male, 51.5%). Echocardiographic parameters including LV geometry, systolic, and diastolic functions were measured at baseline and follow-up. The median follow-up was 24 months (from 12 months to 48 months). The entire cohort showed a significant increase in LV wall thickness, LV mass (LVM), and prevalence of concentric hypertrophy (19.6-27.3%). Further, systolic function and diastolic function had deteriorated at follow-up assessment. Multivariable adjusted linear regression demonstrated that baseline body mass index (BMI) predicted longitudinal change to LVM (beta = 0.29, P < 0.01) and LV ejection fraction (beta = -0.15, P < 0.05). Patients were divided into three groups according to their BMI: normal weight (BMI <23 kg/m2), overweight (BMI between 23 kg/m2 and 27.5 kg/m2), or obese (BMI >/=27.5 kg/m2). Importantly, obesity at baseline predicted a greater longitudinal increase in LVM and decrease in LV ejection fraction compared with overweight and normal weight patients. CONCLUSION: Being obese at baseline was associated with greater longitudinal increase in LV mass and greater deterioration in LV systolic function. CI - Published on behalf of the European Society of Cardiology. All rights reserved. (c) The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. FAU - Wu, Mei-Zhen AU - Wu MZ AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. AD - Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Chen, Yan AU - Chen Y AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. AD - Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Zou, Yuan AU - Zou Y AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. AD - Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Zhen, Zhe AU - Zhen Z AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. AD - Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Yu, Yu-Juan AU - Yu YJ AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. AD - Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. FAU - Liu, Ying-Xian AU - Liu YX AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. FAU - Yuen, Michele AU - Yuen M AD - Division of Endocrinology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. FAU - Ho, Lai-Ming AU - Ho LM AD - School of Public Health, The University of Hong Kong, Hong Kong, China. FAU - Siu-Ling Lam, Karen AU - Siu-Ling Lam K AD - Division of Endocrinology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. FAU - Tse, Hung-Fat AU - Tse HF AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. FAU - Yiu, Kai-Hang AU - Yiu KH AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, 102 Pokfulam Road, Hong Kong, China. AD - Division of Cardiology, Department of Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. LA - eng PT - Journal Article PL - England TA - Eur Heart J Cardiovasc Imaging JT - European heart journal. Cardiovascular Imaging JID - 101573788 SB - IM MH - Aged MH - Diabetes Mellitus, Type 2/*complications MH - Disease Progression MH - Echocardiography MH - Female MH - Humans MH - Male MH - Middle Aged MH - Obesity/*complications MH - Prospective Studies MH - *Ventricular Remodeling OTO - NOTNLM OT - Type 2 diabetes mellitus OT - body mass index OT - longitudinal cardiac change OT - obesity EDAT- 2019/01/11 06:00 MHDA- 2020/10/06 06:00 CRDT- 2019/01/11 06:00 PHST- 2018/08/28 00:00 [received] PHST- 2018/11/13 00:00 [revised] PHST- 2018/12/29 00:00 [accepted] PHST- 2019/01/11 06:00 [pubmed] PHST- 2020/10/06 06:00 [medline] PHST- 2019/01/11 06:00 [entrez] AID - 5281273 [pii] AID - 10.1093/ehjci/jey217 [doi] PST - ppublish SO - Eur Heart J Cardiovasc Imaging. 2019 Jul 1;20(7):816-827. doi: 10.1093/ehjci/jey217.