PMID- 30629191
OWN - NLM
STAT- MEDLINE
DCOM- 20191129
LR  - 20191129
IS  - 1554-6578 (Electronic)
IS  - 0022-3069 (Linking)
VI  - 78
IP  - 2
DP  - 2019 Feb 1
TI  - Age-Related Changes of the Neurovascular Unit in the Cerebral Cortex of Alzheimer 
      Disease Mouse Models: A Neuroanatomical and Molecular Study.
PG  - 101-112
LID - 10.1093/jnen/nly125 [doi]
AB  - We describe age-related histological structure and molecular changes of the 
      neurovascular unit (NVU) in the cerebral cortex of Tg2576 and age-matched 
      wild-type (WT) mice. Major results can be summarized as follows: (i) beta-amyloid 
      (6E10)-immunoreactivity progressively increases in neurons and astrocytes of 
      Tg2576 mice, reaching the highest concentration at 5 months and then decreasing 
      as soon as extracellular plaque deposition begins; (ii) the synaptic puncta 
      density of glutamatergic and GABAergic neurons in Tg2576 mice is unbalanced 
      versus WT at all investigated ages, with a decrease in synaptophysin and VGLUT1; 
      density of VGAT contacts is higher in 27-month-old Tg2576 versus WT mice; (iii) 
      capillary density is higher in 5-month-old Tg2576 versus WT mice, then decreases 
      to a lower density at 27 months, when the capillary-astrocyte interface is lower; 
      and (iv) mRNA expression of genes involved in microvessel dynamics indicates age- 
      and genotype-dependent changes in the expression levels of hypoxia-related genes, 
      i.e. the highest level is in 5-month-old animals and there is impaired regulation 
      in Tg2576. We conclude that at 5 months, when learning and memory impairment is 
      already present in the absence of extracellular amyloid plaque deposition, Tg2576 
      mice display alterations in the structure and molecular regulation of the NVU.
FAU - Giuliani, Alessandro
AU  - Giuliani A
AD  - Department of Veterinary Medical Sciences (DIMEVET), University of Bologna, 
      Bologna, Italy.
FAU - Sivilia, Sandra
AU  - Sivilia S
AD  - IRET Foundation, Ozzano Emilia, Italy.
FAU - Baldassarro, Vito Antonio
AU  - Baldassarro VA
AD  - Department of Veterinary Medical Sciences (DIMEVET), University of Bologna, 
      Bologna, Italy.
AD  - IRET Foundation, Ozzano Emilia, Italy.
AD  - Pharmacy and Biotechnology Department (FaBiT), University of Bologna, Bologna, 
      Italy.
FAU - Gusciglio, Marco
AU  - Gusciglio M
AD  - IRET Foundation, Ozzano Emilia, Italy.
FAU - Lorenzini, Luca
AU  - Lorenzini L
AD  - IRET Foundation, Ozzano Emilia, Italy.
AD  - Health Science and Technologies Interdepartmental Center for Industrial Research 
      (HST-ICIR), University of Bologna, Bologna, Italy.
FAU - Sannia, Michele
AU  - Sannia M
AD  - Department of Veterinary Medical Sciences (DIMEVET), University of Bologna, 
      Bologna, Italy.
AD  - Health Science and Technologies Interdepartmental Center for Industrial Research 
      (HST-ICIR), University of Bologna, Bologna, Italy.
FAU - Calza, Laura
AU  - Calza L
AD  - IRET Foundation, Ozzano Emilia, Italy.
AD  - Health Science and Technologies Interdepartmental Center for Industrial Research 
      (HST-ICIR), University of Bologna, Bologna, Italy.
AD  - Pharmacy and Biotechnology Department (FaBiT), University of Bologna, Bologna, 
      Italy.
FAU - Giardino, Luciana
AU  - Giardino L
AD  - Department of Veterinary Medical Sciences (DIMEVET), University of Bologna, 
      Bologna, Italy.
AD  - IRET Foundation, Ozzano Emilia, Italy.
AD  - Health Science and Technologies Interdepartmental Center for Industrial Research 
      (HST-ICIR), University of Bologna, Bologna, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
SB  - IM
MH  - Aging/*pathology
MH  - Alzheimer Disease/*pathology
MH  - Animals
MH  - Astrocytes/*pathology
MH  - Cerebral Cortex/*pathology
MH  - Disease Models, Animal
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Neurons/*pathology
EDAT- 2019/01/11 06:00
MHDA- 2019/11/30 06:00
CRDT- 2019/01/11 06:00
PHST- 2019/01/11 06:00 [pubmed]
PHST- 2019/11/30 06:00 [medline]
PHST- 2019/01/11 06:00 [entrez]
AID - 5281410 [pii]
AID - 10.1093/jnen/nly125 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2019 Feb 1;78(2):101-112. doi: 10.1093/jnen/nly125.