PMID- 30632188
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20190726
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 36
IP  - 3
DP  - 2019 Mar
TI  - Left ventricular metabolic remodeling and accompanied dysfunction in type 2 
      diabetic patients: A 3D speckle tracking analysis.
PG  - 486-494
LID - 10.1111/echo.14248 [doi]
AB  - PURPOSES: The purposes of our study were to determine the risk factors related to 
      metabolic left ventricular remodeling (LVR) in type 2 diabetes mellitus (T2DM) 
      patients and to assess the LV function with different geometry in such 
      population. METHODS: Seventy-eight T2DM patients with normal 2D-LVEF (>/=55%) were 
      enrolled and divided into two groups with LV normal geometry (LVN) and with LV 
      remodeling (LVR). The control group was composed of forty age- and sex-matched 
      healthy individuals with LVN. A multifactor logistic regression was used to 
      determine the risk factors for LVR, and their diagnostic values were evaluated 
      using the area under the ROC curves (AUC). Three-dimensional speckle tracking 
      echocardiography (3DSTE) was used to measure LV global longitudinal strain (GLS), 
      global circumferential strain (GCS), global area strain (GAS), and global radial 
      strain (GRS). RESULTS: Fasting plasma glucose (FPG), hyperlipidemia, and BMI were 
      independently associated with LVR in T2DM patients, and the AUC values were 
      0.699, 0.697, and 0.732, respectively. The T2DM patients with LVN showed 
      significantly lower GLS than the controls (P < 0.05), whereas the T2DM patients 
      with LVR showed significantly lower GLS, GCS, GAS, and GRS than the T2DM patients 
      with LVN (all P < 0.01). Additionally, GLS, GAS, and GRS values decreased 
      significantly in the T2DM patients with LV hypertrophy than in those with LV 
      concentric remodeling (all P < 0.05). CONCLUSIONS: The routine echocardiography 
      and 3DSTE could be used in combining way to detect the metabolic LV remodeling 
      and accompanied dysfunction in T2DM patients.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Wang, Qingqing
AU  - Wang Q
AUID- ORCID: 0000-0002-6950-0631
AD  - Department of Ultrasound, Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Tan, Kaibin
AU  - Tan K
AD  - Department of Ultrasound, The Third Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Xia, Hongmei
AU  - Xia H
AD  - Department of Ultrasound, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing, China.
FAU - Gao, Yunhua
AU  - Gao Y
AD  - Department of Ultrasound, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20190110
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Echocardiography
MH  - Echocardiography, Three-Dimensional/*methods
MH  - Female
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Ventricular Dysfunction, Left/*complications/*diagnostic imaging/physiopathology
MH  - Ventricular Remodeling/*physiology
OTO - NOTNLM
OT  - LV dysfunction
OT  - left ventricular remodeling
OT  - risk factors
OT  - three-dimensional speckle tracking echocardiography
OT  - type 2 diabetes mellitus
EDAT- 2019/01/12 06:00
MHDA- 2019/07/28 06:00
CRDT- 2019/01/12 06:00
PHST- 2018/10/16 00:00 [received]
PHST- 2018/11/20 00:00 [revised]
PHST- 2018/12/07 00:00 [accepted]
PHST- 2019/01/12 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
PHST- 2019/01/12 06:00 [entrez]
AID - 10.1111/echo.14248 [doi]
PST - ppublish
SO  - Echocardiography. 2019 Mar;36(3):486-494. doi: 10.1111/echo.14248. Epub 2019 Jan 
      10.