PMID- 30632770
OWN - NLM
STAT- MEDLINE
DCOM- 20200331
LR  - 20200331
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 60
IP  - 4
DP  - 2020
TI  - Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, 
      and potential.
PG  - 670-683
LID - 10.1080/10408398.2018.1547268 [doi]
AB  - Type 2 diabetes mellitus (T2DM) has become one of the most prevalent diseases on 
      earth and several treatments have been developed. However, the current 
      intervention approaches have not been as effective as expected. One promising 
      supplementary strategy is the use of probiotics through direct or indirect 
      approaches. Probiotics are microbial food cultures conferring health-promoting 
      properties. In this review, we summarized the current theories and mechanisms of 
      T2DM intervention using probiotics and hypothesize that probiotics intervene T2DM 
      during its onsetting, developing, and complicating. For the first time, we 
      comprehensively analyzed T2DM intervention in animal models using both wide-type 
      probiotics in different forms and using recombinant probiotics. Then, probiotic 
      intervention in T2DM patients was reviewed and the main results were compared 
      with that obtained from animal studies. Finally yet importantly, remaining 
      questions that are important such as in which form and in which state, as well as 
      the future potential of probiotic intervention in T2DM were discussed from a 
      perspective of food microbiologists. In conclusion, probiotic intervention in 
      T2DM is promising but there are still many important issues unsolved yet. 
      Critical review of the advances, questions, and potential of probiotic 
      intervention in T2DM promotes the development of this approach for further 
      application in humans.
FAU - Sun, Zhongke
AU  - Sun Z
AD  - College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, China.
AD  - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 
      China.
FAU - Sun, Xuejiao
AU  - Sun X
AD  - College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, China.
AD  - College of Life Sciences, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Li, Juan
AU  - Li J
AD  - College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, China.
FAU - Li, Zhaoyang
AU  - Li Z
AD  - College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, China.
FAU - Hu, Qingwei
AU  - Hu Q
AD  - Zhoukou Maternal and Child Health Care Hospital, Zhoukou, China.
FAU - Li, Lili
AU  - Li L
AD  - College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, China.
FAU - Hao, Xinqi
AU  - Hao X
AD  - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 
      China.
FAU - Song, Maoping
AU  - Song M
AD  - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 
      China.
FAU - Li, Chengwei
AU  - Li C
AD  - College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, China.
AD  - College of Life Sciences, Henan Institute of Science and Technology, Xinxiang, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190111
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*microbiology/*therapy
MH  - Humans
MH  - Probiotics/*therapeutic use
OTO - NOTNLM
OT  - Probiotics
OT  - diabetes mellitus
OT  - glucose
OT  - immunity
OT  - insulin
EDAT- 2019/01/12 06:00
MHDA- 2020/04/01 06:00
CRDT- 2019/01/12 06:00
PHST- 2019/01/12 06:00 [pubmed]
PHST- 2020/04/01 06:00 [medline]
PHST- 2019/01/12 06:00 [entrez]
AID - 10.1080/10408398.2018.1547268 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2020;60(4):670-683. doi: 10.1080/10408398.2018.1547268. 
      Epub 2019 Jan 11.