PMID- 30632863
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 1549-781X (Electronic)
IS  - 1040-8363 (Linking)
VI  - 56
IP  - 2
DP  - 2019 Mar
TI  - The immunology of the macaque placenta: A detailed analysis and critical 
      comparison with the human placenta.
PG  - 118-145
LID - 10.1080/10408363.2018.1538200 [doi]
AB  - The cynomolgus monkey is increasingly considered in toxicological research as the 
      most appropriate model for humans due to the species' close physiological 
      contiguity, including reproductive physiology. Here, literature on the cynomolgus 
      monkey placenta is reviewed in regards to its similarity to the human placenta 
      and particularly for its immunological role, which is not entirely mirrored in 
      humans. Pertinent original data are included in this article. The cynomolgus 
      monkey placenta is evaluated based on three aspects: first, morphological 
      development; second, the spatial and temporal appearance of maternal and fetal 
      immune cells and certain immune cell products of the innate and adaptive immune 
      systems; and third, the expression of relevant immune tolerance-related molecules 
      including the homologs of anti-human leucocyte antigen, indoleamine 
      2,3-dioxygenase, FAS/FAS-L, annexin II, and progesterone. Parameters relevant to 
      the immunological role of the placenta are evaluated from the immunologically 
      immature stage of gestational day (GD) 50 until more mature stages close to 
      birth. Selected comparisons are drawn with human and other laboratory animal 
      placentas. In conclusion, the cynomolgus monkey placenta has a high degree of 
      morphological and physiological similarity to the human placenta. However, there 
      are differences in the topographical distribution of cell types and immune 
      tolerance-related molecules. Three basic features are recognized: (1) the 
      immunological capacity of the placenta changes throughout the lifetime of the 
      organ; (2) these immunological changes include multiple parameters such as 
      morphological adaptations, cell type involvement, and changes in immune-relevant 
      molecule expression; and (3) the immune systems of two genetically disparate 
      individuals (mother and child) are functionally intertwined at the maternal-fetal 
      interface.
FAU - Buse, Eberhard
AU  - Buse E
AD  - a Prof. Emeritus, Munster , Germany.
FAU - Markert, Udo R
AU  - Markert UR
AUID- ORCID: 0000-0001-5299-595X
AD  - b Placenta Lab, Department of Obstetrics , University Hospital Jena , Jena , 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190111
PL  - England
TA  - Crit Rev Clin Lab Sci
JT  - Critical reviews in clinical laboratory sciences
JID - 8914816
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Macaca fascicularis/*immunology
MH  - Placenta/cytology/*immunology/physiology
MH  - Pregnancy
OTO - NOTNLM
OT  - Cynomolgus monkey
OT  - immune tolerance
OT  - macaque
OT  - placenta
OT  - placental development
OT  - placental immune cells
OT  - placental morphology
OT  - reproduction
OT  - reproductive immunology
OT  - reproductive toxicology
EDAT- 2019/01/12 06:00
MHDA- 2020/04/21 06:00
CRDT- 2019/01/12 06:00
PHST- 2019/01/12 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/01/12 06:00 [entrez]
AID - 10.1080/10408363.2018.1538200 [doi]
PST - ppublish
SO  - Crit Rev Clin Lab Sci. 2019 Mar;56(2):118-145. doi: 
      10.1080/10408363.2018.1538200. Epub 2019 Jan 11.