PMID- 30632978
OWN - NLM
STAT- MEDLINE
DCOM- 20190513
LR  - 20190513
IS  - 2310-6972 (Print)
IS  - 2310-6905 (Linking)
VI  - 64
IP  - 6
DP  - 2018 Nov
TI  - [Increase of antituberculosis efficiency of rifampicin embedded into phospholipid 
      nanoparticles with sodium oleate].
PG  - 505-510
LID - 10.18097/PBMC20186406505 [doi]
AB  - The formulation of the antituberculosis drug rifampicin embedded into 20-30 nm 
      nanoparticles from soy phosphatidylcholine and sodium oleate, is characterized by 
      greater bioavailability as compared with free drug substance. In this study 
      higher antituberculosis activity of this formulation was shown. Rifampicin in 
      nanoparticles demonstrated more effective inhibition of M. tuberculosis H37Rv 
      growth: minimal inhibiting concentration (MIC) was twice smaller than for free 
      rifampicin. Administration of this preparation to mice with tuberculosis induced 
      by M. tuberculosis Erdman revealed that after 6 weeks of oral administration the 
      CUF value in lung was 22 times smaller for rifampicin in nanoparticles than for 
      free drug (1.7 un. vs. 37.4 un.). The LD50 value in mice was two fold higher for 
      rifampicin in nanoformulation.
FAU - Sanzhakov, M A
AU  - Sanzhakov MA
AD  - Institute of Biomedical Chemistry, Moscow, Russia.
FAU - Ipatova, O M
AU  - Ipatova OM
AD  - Institute of Biomedical Chemistry, Moscow, Russia.
FAU - Torkhovskaya, T I
AU  - Torkhovskaya TI
AD  - Institute of Biomedical Chemistry, Moscow, Russia; Scientific Research Institute 
      of Physical-Chemical Medicine, Moscow, Russia.
FAU - Tikhonova, E G
AU  - Tikhonova EG
AD  - Institute of Biomedical Chemistry, Moscow, Russia; PLC "IBMH-EcoBioPharm", 
      Moscow, Russia.
FAU - Medvedeva, N V
AU  - Medvedeva NV
AD  - Institute of Biomedical Chemistry, Moscow, Russia.
FAU - Zakharova, T S
AU  - Zakharova TS
AD  - Institute of Biomedical Chemistry, Moscow, Russia.
FAU - Prozorovskiy, V N
AU  - Prozorovskiy VN
AD  - Institute of Biomedical Chemistry, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Povyshenie protivotuberkuleznogo deistviia rifampitsina pri vstraivanii v 
      fosfolipidnye nanochastitsy c oleatom natriia.
PL  - Russia (Federation)
TA  - Biomed Khim
JT  - Biomeditsinskaia khimiia
JID - 101196966
RN  - 0 (Antitubercular Agents)
RN  - 0 (Drug Carriers)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - 399SL044HN (osteum)
RN  - VJT6J7R4TR (Rifampin)
SB  - IM
MH  - Animals
MH  - Antitubercular Agents/*pharmacology
MH  - *Drug Carriers
MH  - Mice
MH  - Mycobacterium tuberculosis/drug effects
MH  - *Nanoparticles
MH  - *Oleic Acid
MH  - Rifampin/*pharmacology
OTO - NOTNLM
OT  - CUF
OT  - M. tuberculosis
OT  - antituberculosis therapy
OT  - cell growth
OT  - phospholipid nanoparticles
OT  - rifampicin
EDAT- 2019/01/12 06:00
MHDA- 2019/05/14 06:00
CRDT- 2019/01/12 06:00
PHST- 2019/01/12 06:00 [entrez]
PHST- 2019/01/12 06:00 [pubmed]
PHST- 2019/05/14 06:00 [medline]
AID - 10.18097/PBMC20186406505 [doi]
PST - ppublish
SO  - Biomed Khim. 2018 Nov;64(6):505-510. doi: 10.18097/PBMC20186406505.