PMID- 30633736
OWN - NLM
STAT- MEDLINE
DCOM- 20190322
LR  - 20231005
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 25
DP  - 2019 Jan 11
TI  - Efficacy of Sublingual Administration of Dermatophagoides Farinae Drops for 
      Treatment of Pediatric Allergic Rhinitis Accompanied by Adenoid Hypertrophy and 
      Improvement of Immune Function.
PG  - 333-340
LID - 10.12659/MSM.911982 [doi]
AB  - BACKGROUND The aim of this study was to determine the efficacy of sublingual 
      administration of Dermatophagoides farinae drops for the treatment of allergic 
      rhinitis (AR) accompanied by adenoid hypertrophy and the effect on immune 
      function in children. MATERIAL AND METHODS Eosinophil counts in peripheral blood 
      before and after treatment were determined; serum levels of immunoglobulin E 
      (IgE), total IgE (T-IgE), immunoglobulin G4 (IgG4), interleukin-2 (IL-2), and 
      interleukin-6 (IL-6) before and after treatment were detected by enzyme-linked 
      immunosorbent assay. RESULTS The total effective rate in the study group was 
      significantly higher than that in the control group (P<0.05). In both the study 
      and control groups, symptom scores, medication scores, eosinophil counts in the 
      peripheral blood, and serum levels of IgE, T-IgE, and IL-6 were significantly 
      lower than those before treatment (P<0.05), while the serum levels of IgG4 and 
      IL-2 were significantly higher than those before treatment (P<0.05). After 
      treatment, symptom scores, medication scores, eosinophil counts in the peripheral 
      blood, and serum levels of IgE, T-IgE, and IL-6 in the study group were 
      significantly lower than those in the control group (P<0.05), while the serum 
      levels of IgG4 and IL-2 were significantly higher in the study group than those 
      in the control group (P<0.05). CONCLUSIONS Sublingual administration of D. 
      farinae drops improved the clinical symptoms of pediatric AR caused by 
      Dermatophagoides mites and improved the immune functions in children.
FAU - Yu, Wangbo
AU  - Yu W
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Affiliated Hospital of 
      North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
FAU - Mao, Lifang
AU  - Mao L
AD  - Department of Integrated Western and Chinese Colorectal and Anal Surgery, 
      Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China 
      (mainland).
FAU - Pan, Qingchun
AU  - Pan Q
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Affiliated Hospital of 
      North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
FAU - He, Tao
AU  - He T
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Affiliated Hospital of 
      North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
FAU - Yu, Ming
AU  - Yu M
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Affiliated Hospital of 
      Guizhou Medical University, Guiyang, Guizhou, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20190111
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-6)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adenoids/drug effects/physiopathology
MH  - Administration, Sublingual
MH  - Animals
MH  - Asthma/immunology
MH  - Child
MH  - Child, Preschool
MH  - Dermatophagoides farinae/*immunology
MH  - Desensitization, Immunologic/*methods
MH  - Eosinophils/drug effects
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/analysis/blood
MH  - Immunoglobulin G/analysis/blood
MH  - Interleukin-2/analysis/blood
MH  - Interleukin-6/analysis/blood
MH  - Male
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/*therapy
MH  - Sublingual Immunotherapy/methods
MH  - Treatment Outcome
PMC - PMC6338006
COIS- Conflict of interest None.
EDAT- 2019/01/12 06:00
MHDA- 2019/03/23 06:00
PMCR- 2019/01/11
CRDT- 2019/01/12 06:00
PHST- 2019/01/12 06:00 [entrez]
PHST- 2019/01/12 06:00 [pubmed]
PHST- 2019/03/23 06:00 [medline]
PHST- 2019/01/11 00:00 [pmc-release]
AID - 911982 [pii]
AID - 10.12659/MSM.911982 [doi]
PST - epublish
SO  - Med Sci Monit. 2019 Jan 11;25:333-340. doi: 10.12659/MSM.911982.