PMID- 30633768
OWN - NLM
STAT- MEDLINE
DCOM- 20191118
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 1
DP  - 2019
TI  - Outcomes of cardiac resynchronization therapy in patients with atrial 
      fibrillation accompanied by slow ventricular response.
PG  - e0210603
LID - 10.1371/journal.pone.0210603 [doi]
LID - e0210603
AB  - It remains unclear as to whether cardiac resynchronization therapy (CRT) would be 
      as effective in patients with atrial fibrillation (AF) accompanied by slow 
      ventricular response (AF-SVR, < 60 beats/min) as in those with sinus rhythm (SR). 
      Echocardiographic reverse remodeling was compared between AF-SVR patients (n = 
      17) and those with SR (n = 88) at six months and 12 months after CRT treatment. 
      We also evaluated the changes in QRS duration; New York Heart Association (NYHA) 
      functional class; and long-term composite clinical outcomes including cardiac 
      death, heart transplantation, and heart failure (HF)-related hospitalization. 
      Left ventricular pacing sites and biventricular pacing percentages were not 
      significantly different between the AF-SVR and SR groups. However, heart rate 
      increase after CRT was significantly greater in the AF-SVR group than in the SR 
      group (P < 0.001). At six and 12 months postoperation, both groups showed a 
      comparable improvement in NYHA class; QRS narrowing; and echocardiographic 
      variables including left ventricular end-systolic volume, left ventricular 
      ejection fraction, and left atrial volume index. Over the median follow-up 
      duration of 1.6 (interquartile range: 0.8-2.2) years, no significant 
      between-group differences were observed regarding the rates of long-term 
      composite clinical events (35% versus 24%; hazard ratio: 1.71; 95% confidence 
      interval: 0.23-12.48; P = 0.60). CRT implantation provided comparable beneficial 
      effects for patients with AF-SVR as compared with those with SR, by correcting 
      electrical dyssynchrony and increasing biventricular pacing rate, in terms of QRS 
      narrowing, symptom improvement, ventricular reverse remodeling, and long-term 
      clinical outcomes.
FAU - Hwang, Jin Kyung
AU  - Hwang JK
AD  - Division of Cardiology, Department of Medicine, Veterans Health Service Medical 
      Center, Seoul, Korea.
FAU - Gwag, Hye Bin
AU  - Gwag HB
AD  - Division of Cardiology, Department of Medicine, Samsung Medical Center, 
      Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Park, Kyoung-Min
AU  - Park KM
AD  - Division of Cardiology, Department of Medicine, Samsung Medical Center, 
      Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - On, Young Keun
AU  - On YK
AD  - Division of Cardiology, Department of Medicine, Samsung Medical Center, 
      Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Kim, June Soo
AU  - Kim JS
AD  - Division of Cardiology, Department of Medicine, Samsung Medical Center, 
      Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Park, Seung-Jung
AU  - Park SJ
AUID- ORCID: 0000-0003-3288-0594
AD  - Division of Cardiology, Department of Medicine, Samsung Medical Center, 
      Sunkyunkwan University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190111
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/physiopathology/*therapy
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Heart Failure/physiopathology/*therapy
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Ventricular Dysfunction/physiopathology/*therapy
MH  - Ventricular Remodeling
PMC - PMC6329507
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/01/12 06:00
MHDA- 2019/11/19 06:00
PMCR- 2019/01/11
CRDT- 2019/01/12 06:00
PHST- 2018/09/18 00:00 [received]
PHST- 2018/12/30 00:00 [accepted]
PHST- 2019/01/12 06:00 [entrez]
PHST- 2019/01/12 06:00 [pubmed]
PHST- 2019/11/19 06:00 [medline]
PHST- 2019/01/11 00:00 [pmc-release]
AID - PONE-D-18-27162 [pii]
AID - 10.1371/journal.pone.0210603 [doi]
PST - epublish
SO  - PLoS One. 2019 Jan 11;14(1):e0210603. doi: 10.1371/journal.pone.0210603. 
      eCollection 2019.