PMID- 30634146
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20190315
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 221
DP  - 2019 Apr
TI  - Therapeutic effect of N- acetyl cysteine as an antioxidant on rainbow trout's 
      brain in cypermethrin toxicity.
PG  - 30-36
LID - S0045-6535(18)32538-4 [pii]
LID - 10.1016/j.chemosphere.2018.12.196 [doi]
AB  - The aim of this study was to investigate the therapeutic effect of 
      N-acetylcystein (NAC) against oxidative stress induced by Cypermethrin pesticide 
      in rainbow trout (Oncorhynchus mykiss). The experiment was designed as 5 groups 
      (A, B, C, D, and E). Group A was organized as control group and had no treatment. 
      The other groups were treated with Cypermethrin for 14 days. At the end of this 
      period, Groups B (1.0 mM NAC) and D (0.5 mM NAC) was performed with NAC for 96 h. 
      Group C was not administered NAC, the recovery process was evaluated with this 
      group. Group E was exposed to cypermethrin during 14 days and sampled. 
      Acetylcholinesterase (AChE), malondialdehyde (MDA), glutathione peroxidase (GPx), 
      superoxide dismutase (SOD), catalase (CAT), paraoxonase (PON), arylesterase (AR), 
      myeloperoxidase (MPO) activities, oxidative DNA damage 
      (8-hydroxy-2'-deoxyguanosine (8-OHdG)), caspase-3 levels, and trace elements 
      contents analyses were performed in all fish brains. According to the results, 
      MDA, MPO, 8-OHdG and caspase-3 levels were significantly decreased compared to 
      the other groups (pesticide and recovery) (p < 0.05), AChE, SOD, CAT, GPx, PON, 
      and AR activities increased (p < 0.05). In brain tissue, no statistically 
      significant difference was observed in trace element analysis of all application 
      groups. According to the obtained data, the positive effect of N-acetylcysteine 
      on protein synthesis, detoxification, and diverse metabolic functions against 
      cypermethrin toxicity has been more effective in 1.0 mM NAC. NAC has important 
      therapeutic effect on pesticide-induced neurotoxicity for fish in terms of all 
      data. It was concluded that NAC has an antioxidant effect against 
      pesticide-induced oxidative stress and the selected biochemical markers are 
      useful for such studies.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Alak, Gonca
AU  - Alak G
AD  - Department of Aquaculture, Faculty of Fisheries, Ataturk University, TR-25030 
      Erzurum, Turkey. Electronic address: galak@atauni.edu.tr.
FAU - Yeltekin, Asli Cilingir
AU  - Yeltekin AC
AD  - Department of Chemistry, Faculty of Science, University of Yuzuncu Yil, TR-65080, 
      Van, Turkey.
FAU - Ozgeris, Fatma Betul
AU  - Ozgeris FB
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ataturk 
      University, TR-25030 Erzurum, Turkey.
FAU - Parlak, Veysel
AU  - Parlak V
AD  - Department of Aquaculture, Faculty of Fisheries, Ataturk University, TR-25030 
      Erzurum, Turkey.
FAU - Ucar, Arzu
AU  - Ucar A
AD  - Department of Aquaculture, Faculty of Fisheries, Ataturk University, TR-25030 
      Erzurum, Turkey.
FAU - Sait Keles, M
AU  - Sait Keles M
AD  - Department of Biochemistry, Faculty of Medicine, Ataturk University, TR-25030 
      Erzurum, Turkey.
FAU - Atamanalp, Muhammed
AU  - Atamanalp M
AD  - Department of Aquaculture, Faculty of Fisheries, Ataturk University, TR-25030 
      Erzurum, Turkey. Electronic address: mataman@atauni.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20190104
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Antioxidants)
RN  - 0 (Pesticides)
RN  - 0 (Pyrethrins)
RN  - 1TR49121NP (cypermethrin)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/pharmacology/*therapeutic use
MH  - Animals
MH  - Antioxidants/metabolism/*therapeutic use
MH  - Brain/drug effects/*metabolism
MH  - Oncorhynchus mykiss/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Pesticides/toxicity
MH  - Pyrethrins/*toxicity
OTO - NOTNLM
OT  - 8-OHdG
OT  - AChE
OT  - Caspase-3
OT  - Fish
OT  - N-Acetylcysteine
OT  - Pesticide
EDAT- 2019/01/12 06:00
MHDA- 2019/03/16 06:00
CRDT- 2019/01/12 06:00
PHST- 2018/10/23 00:00 [received]
PHST- 2018/12/27 00:00 [revised]
PHST- 2018/12/29 00:00 [accepted]
PHST- 2019/01/12 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2019/01/12 06:00 [entrez]
AID - S0045-6535(18)32538-4 [pii]
AID - 10.1016/j.chemosphere.2018.12.196 [doi]
PST - ppublish
SO  - Chemosphere. 2019 Apr;221:30-36. doi: 10.1016/j.chemosphere.2018.12.196. Epub 
      2019 Jan 4.