PMID- 30634489
OWN - NLM
STAT- MEDLINE
DCOM- 20190529
LR  - 20200309
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 16
IP  - 2
DP  - 2019 Jan 9
TI  - Effects of Developmental Arsenic Exposure on the Social Behavior and Related Gene 
      Expression in C3H Adult Male Mice.
LID - 10.3390/ijerph16020174 [doi]
LID - 174
AB  - Arsenic is carcinogenic and teratogenic. In addition, it is also a developmental 
      neurotoxicant. Little is known however about the effect of arsenic exposure 
      during brain development on social behavior. This study aimed to detect the 
      effect of developmental arsenic exposure on social behavior and related gene 
      expression in C3H adult male mice. Pregnant C3H mice were exposed to sodium 
      arsenite (NaAsO(2), 85 ppm in the drinking water) from gestational day (GD) 8 to 
      18. The F1 generation male pups from different mothers were taken and social 
      behavior tasks were examined. Social behavioral-related gene expression in the 
      prefrontal cortex was determined by the real-time RT-PCR method. The mice with 
      developmental arsenic exposure showed poor sociability and poor social novelty 
      preference. Glutamate receptor expression (NMDA and AMPA receptor subunits) 
      showed no significant difference, but gene expressions of serotonin receptor 5B 
      (5-HT 5B) and brain-derived neurotrophic factor (BDNF) were significantly 
      decreased (p < 0.05) in the arsenic-exposed group compared to control group. The 
      heme oxygenase-1 (HO-1) and cyclooxygenase-2 (COX-2) gene expressions were not 
      significantly different. Our findings indicate that developmental arsenic 
      exposure might affect social behavior by modulating serotonin receptors and 
      reducing BDNF. Some oxidative stress markers and inflammatory markers were not 
      affected.
FAU - Htway, Soe-Minn
AU  - Htway SM
AD  - Department of Physiology, University of Medicine, Magway, Magway 04011, Myanmar. 
      drsmhtway@gmail.com.
FAU - Sein, Mya-Thanda
AU  - Sein MT
AUID- ORCID: 0000-0002-5135-3418
AD  - Department of Physiology, University of Medicine, Magway, Magway 04011, Myanmar. 
      dr.myathandasein@gmail.com.
FAU - Nohara, Keiko
AU  - Nohara K
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies, Tsukuba 305-8506, Japan. keikon@nies.go.jp.
FAU - Win-Shwe, Tin-Tin
AU  - Win-Shwe TT
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies, Tsukuba 305-8506, Japan. tin.tin.win.shwe@nies.go.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190109
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Arsenites)
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carcinogens)
RN  - 0 (Receptors, Ionotropic Glutamate)
RN  - 0 (Sodium Compounds)
RN  - 48OVY2OC72 (sodium arsenite)
SB  - IM
MH  - Animals
MH  - Arsenites/*toxicity
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Carcinogens/*toxicity
MH  - Female
MH  - Gene Expression/*drug effects
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Mice, Inbred C3H
MH  - Pregnancy
MH  - Receptors, Ionotropic Glutamate/genetics
MH  - *Social Behavior
MH  - Sodium Compounds/*toxicity
PMC - PMC6352149
OTO - NOTNLM
OT  - arsenic
OT  - developmental
OT  - gene expression
OT  - mice
OT  - prefrontal cortex
OT  - social behavior
COIS- The authors declare no conflict of interest.
EDAT- 2019/01/13 06:00
MHDA- 2019/05/30 06:00
PMCR- 2019/01/01
CRDT- 2019/01/13 06:00
PHST- 2018/11/30 00:00 [received]
PHST- 2019/01/03 00:00 [revised]
PHST- 2019/01/03 00:00 [accepted]
PHST- 2019/01/13 06:00 [entrez]
PHST- 2019/01/13 06:00 [pubmed]
PHST- 2019/05/30 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - ijerph16020174 [pii]
AID - ijerph-16-00174 [pii]
AID - 10.3390/ijerph16020174 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2019 Jan 9;16(2):174. doi: 
      10.3390/ijerph16020174.