PMID- 30635022
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20200225
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Print)
IS  - 1364-8535 (Linking)
VI  - 23
IP  - 1
DP  - 2019 Jan 11
TI  - Predicting mortality in patients undergoing VA-ECMO after coronary artery bypass 
      grafting: the REMEMBER score.
PG  - 11
LID - 10.1186/s13054-019-2307-y [doi]
LID - 11
AB  - BACKGROUND: Prediction scoring systems for coronary artery bypass grafting (CABG) 
      patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) have not 
      yet been reported. This study was designed to develop a predictive score for 
      in-hospital mortality for cardiogenic shock patients who received VA-ECMO after 
      isolated CABG. METHODS: Retrospective cohort study of consecutive CABG patients 
      supported with VA-ECMO (n = 166) at the Beijing Anzhen Hospital between February 
      2004 and March 2017. RESULTS: One hundred and six patients (64%) could be weaned 
      from VA-ECMO, and 74 patients (45%) survived to hospital discharge. On the basis 
      of multivariable logistic regression analyses, the pRedicting mortality in 
      patients undergoing veno-arterial Extracorporeal MEMBrane oxygenation after 
      coronary artEry bypass gRafting (REMEMBER) score was created with six pre-ECMO 
      parameters: older age, left main coronary artery disease, inotropic score > 75, 
      CK-MB > 130 IU/L, serum creatinine > 150 umol/L, and platelet count 
      < 100 x 10(9)/L. Four risk classes, namely class I (REMEMBER score 0-13), class 
      II (14-19), class III (20-25), and class IV (> 25) with their corresponding 
      mortality (13%, 55%, 70%, and 94%, respectively), were identified. The area under 
      the receiver operating characteristic curve 0.85(95% CI 0.79-0.91) for the 
      REMEMBER score was better than those for the SOFA, SAVE, EuroSCORE, and ENCOURAGE 
      scores in this population. CONCLUSIONS: The REMEMBER score might help clinicians 
      at bedside to predict in-hospital mortality for patients receiving VA-ECMO after 
      isolated CABG for refractory cardiogenic shock. Prospective studies are needed to 
      externally validate this scoring system.
FAU - Wang, Liangshan
AU  - Wang L
AD  - Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Yang, Feng
AU  - Yang F
AD  - Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Wang, Xiaomeng
AU  - Wang X
AD  - Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Xie, Haixiu
AU  - Xie H
AD  - Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Fan, Eddy
AU  - Fan E
AD  - Interdepartmental Division of Critical Care Medicine, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Ogino, Mark
AU  - Ogino M
AD  - Division of Neonatology, Nemours/Alfred I. DuPont Hospital for Children, 
      Wilmington, Delaware, USA.
FAU - Brodie, Daniel
AU  - Brodie D
AD  - Columbia University College of Physicians and Surgeons/New York-Presbyterian 
      Hospital, New York, NY, USA.
FAU - Wang, Hong
AU  - Wang H
AD  - Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Hou, Xiaotong
AU  - Hou X
AD  - Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China. xt.hou@ccmu.edu.cn.
LA  - eng
GR  - 2016YFC1301001, to X Hou/The National Key Research and Development Program of 
      China/
PT  - Journal Article
DEP - 20190111
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
CIN - Crit Care. 2019 Mar 7;23(1):71. PMID: 30845996
CIN - Crit Care. 2019 Jun 3;23(1):199. PMID: 31159848
CIN - Ann Transl Med. 2019 Jul;7(Suppl 3):S100. PMID: 31576307
MH  - Aged
MH  - Area Under Curve
MH  - Cohort Studies
MH  - Coronary Artery Bypass/*statistics & numerical data
MH  - Extracorporeal Membrane Oxygenation/methods/*mortality
MH  - Female
MH  - Forecasting/*methods
MH  - Hospital Mortality
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Organ Dysfunction Scores
MH  - Prospective Studies
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Shock, Cardiogenic/mortality/therapy
PMC - PMC6330483
OTO - NOTNLM
OT  - Cardiogenic shock
OT  - Coronary artery bypass grafting
OT  - Mortality
OT  - Venoarterial extracorporeal membrane oxygenation
OT  - pRedicting mortality in patients undergoing veno-arterial Extracorporeal MEMBrane 
      oxygenation after coronary artEry bypass gRafting (REMEMBER) score
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study was approved by the 
      institutional ethics committee/review board of the Beijing Anzhen Hospital. 
      Informed consent for demographic, physiological and hospital-outcome data 
      analyses was not obtained because this observational study did not modify 
      existing diagnostic or therapeutic strategies. However, patients and/or relatives 
      were informed about the anonymous data collection and that they could decline 
      inclusion. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The 
      authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer 
      Nature remains neutral with regard to jurisdictional claims in published maps and 
      institutional affiliations.
EDAT- 2019/01/13 06:00
MHDA- 2019/10/01 06:00
PMCR- 2019/01/11
CRDT- 2019/01/13 06:00
PHST- 2018/09/05 00:00 [received]
PHST- 2019/01/02 00:00 [accepted]
PHST- 2019/01/13 06:00 [entrez]
PHST- 2019/01/13 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2019/01/11 00:00 [pmc-release]
AID - 10.1186/s13054-019-2307-y [pii]
AID - 2307 [pii]
AID - 10.1186/s13054-019-2307-y [doi]
PST - epublish
SO  - Crit Care. 2019 Jan 11;23(1):11. doi: 10.1186/s13054-019-2307-y.