PMID- 30636257
OWN - NLM
STAT- MEDLINE
DCOM- 20190322
LR  - 20200225
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 25
DP  - 2019 Jan 13
TI  - Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are 
      Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated 
      Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) 
      Expression.
PG  - 389-394
LID - 10.12659/MSM.912922 [doi]
AB  - BACKGROUND Depression is a common disorder linked with high levels of chronicity, 
      psycho-social and physical problems, and suicide. Here, we assessed the 
      antidepressant effects of the hydromethanolic extract of Taraxacum officinale and 
      investigated the underlying mechanism. MATERIAL AND METHODS Antidepressant 
      effects were examined by use of the tail suspension test (TST). Concentrations of 
      corticosterone, dopamine, noradrenaline, and adrenaline were examined by 
      biochemical assays. The mRNA expression was assessed by quantitative RT-PCR. 
      Phytochemical analysis was performed by LC/MS. RESULTS The results showed that 
      the extract at the dosage of 50 and 100 mg/kg significantly (p<0.01) alleviated 
      the TST-induced immobility in the mice, and the effects were comparable to the 
      antidepressant drug Bupropion, which was used as the positive control. 
      Investigation of the underlying mechanism revealed that the T. officinale extract 
      exerts it effects by significantly (p<0.05) decreasing the levels of 
      corticosterone and increasing the concentrations of dopamine, noradrenaline, and 
      adrenaline. Further, the extract also increased the expression of brain-derived 
      neurotrophic factor (Bdnf), which was associated with significant (p<0.05) 
      decrease in the expression of mitogen-activated protein kinase phosphatase-1 
      (Mkp-1), indicative of the antidepressant potential of T. officinale. Finally, 
      the active constituents of the extract, which include isoetin, hesperidin, 
      naringenin, Kaempferol, sinapinic, and gallic acid, were also identified, which 
      could potentially be responsible for its antidepressant effects. CONCLUSIONS In 
      conclusion, T. officinale exerts significant antidepressant effects in a mouse 
      model of depression by inhibition of corticosterone levels and modulation of 
      Mkp-1 and Bdnf expression.
FAU - Gao, Cunyou
AU  - Gao C
AD  - Jiading District Mental Health Center, Shanghai, China (mainland).
FAU - Kong, Suli
AU  - Kong S
AD  - Jiading District Mental Health Center, Shanghai, China (mainland).
AD  - Mental Diseases Prevention and Treatment Institute of Chinese People's Liberation 
      Army (PLA), PLA 91st Central Hospital, Jiaozuo, Henan, China (mainland).
FAU - Guo, Benyu
AU  - Guo B
AD  - Jiading District Mental Health Center, Shanghai, China (mainland).
FAU - Liang, Xuejun
AU  - Liang X
AD  - Mental Diseases Prevention and Treatment Institute of Chinese People's Liberation 
      Army (PLA), PLA 91st Central Hospital, Jiaozuo, Henan, China (mainland).
FAU - Duan, Huifeng
AU  - Duan H
AD  - Mental Diseases Prevention and Treatment Institute of Chinese People's Liberation 
      Army (PLA), PLA 91st Central Hospital, Jiaozuo, Henan, China (mainland).
FAU - Li, Donghe
AU  - Li D
AD  - Mental Diseases Prevention and Treatment Institute of Chinese People's Liberation 
      Army (PLA), PLA 91st Central Hospital, Jiaozuo, Henan, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20190113
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - EC 3.1.3.48 (Dual Specificity Phosphatase 1)
RN  - EC 3.1.3.48 (Dusp1 protein, mouse)
RN  - VTD58H1Z2X (Dopamine)
RN  - W980KJ009P (Corticosterone)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/drug effects/metabolism
MH  - Corticosterone/metabolism
MH  - Depression/*drug therapy/metabolism
MH  - Depressive Disorder/drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Dopamine/analysis
MH  - Dual Specificity Phosphatase 1/drug effects/metabolism
MH  - Epinephrine/analysis
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Norepinephrine/analysis
MH  - Phytotherapy/methods
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Plant Leaves/metabolism
MH  - Stress, Psychological/metabolism
MH  - Swimming
MH  - Taraxacum/*metabolism/physiology
PMC - PMC6340315
EDAT- 2019/01/14 06:00
MHDA- 2019/03/23 06:00
PMCR- 2019/01/13
CRDT- 2019/01/14 06:00
PHST- 2019/01/14 06:00 [entrez]
PHST- 2019/01/14 06:00 [pubmed]
PHST- 2019/03/23 06:00 [medline]
PHST- 2019/01/13 00:00 [pmc-release]
AID - 912922 [pii]
AID - 10.12659/MSM.912922 [doi]
PST - epublish
SO  - Med Sci Monit. 2019 Jan 13;25:389-394. doi: 10.12659/MSM.912922.