PMID- 30636944
OWN - NLM
STAT- MEDLINE
DCOM- 20190419
LR  - 20220331
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 34
IP  - 2
DP  - 2019 Jan 14
TI  - Clinical Characteristics of Oral Allergy Syndrome in Children with Atopic 
      Dermatitis and Birch Sensitization: a Single Center Study.
PG  - e11
LID - 10.3346/jkms.2019.34.e11 [doi]
LID - e11
AB  - BACKGROUND: Oral allergy syndrome (OAS) is an immunoglobulin E (IgE)-mediated 
      hypersensitivity that occurs frequently in older children with pollen 
      sensitization. This study focused on the clinical characteristics of OAS in 
      children with atopic dermatitis (AD) and birch sensitization. METHOD: s: A total 
      of 186 patients aged 2-18 years with AD and birch sensitization were enrolled in 
      this study between January 2016 and March 2017. Their levels of serum total IgE 
      and birch- and ragweed-specific IgE (sIgE) were measured using ImmunoCAP (Thermo 
      Fisher Scienti fi c, Uppsala, Sweden). Information regarding causative foods and 
      symptoms were obtained via interviews. The patients were divided into 3 groups 
      according to their ages (group 1, 2-6 years; group 2, 7-12 years; and group 3, 
      13-18 years). RESULTS: Eighty-one of the 186 (43.5%) children with AD who were 
      sensitized to birch pollen were diagnosed as having OAS. The prevalence of OAS in 
      group 1 (the children who had AD and birch sensitization aged 2-6 years) was 
      36.6%. A greater predominance of men was noted in the non-OAS group (77.1%) 
      compared to the OAS group (60.5%). Apples were the most common causative food in 
      group 2 and 3 while kiwis were the most common cause of OAS in group 1. There was 
      a statistically significant correlation between birch-sIgE levels and the 
      prevalence of OAS (P = 0.000). The cut-off value was 6.77 kU(A)/L with 55.6% 
      sensitivity and 79.0% specificity (area under the curve 0.653). CONCLUSION: In 
      our study, the prevalence of OAS in children with AD and birch sensitization was 
      43.5%. Even in the preschool age group, the prevalence of OAS was considerable. 
      Patients with high levels of birch-sIgE were more likely to have OAS. Clinicians 
      should therefore be vigilant about OAS in patients with a high degree of 
      sensitization to birch pollen and even young children if they have birch 
      sensitization.
FAU - Kim, Kang-In
AU  - Kim KI
AUID- ORCID: 0000-0001-9307-5578
AD  - Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang 
      University Hospital, Seoul, Korea.
FAU - Lee, Bomi
AU  - Lee B
AUID- ORCID: 0000-0002-5004-9916
AD  - Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang 
      University Hospital, Seoul, Korea.
FAU - Min, Taek Ki
AU  - Min TK
AUID- ORCID: 0000-0002-5078-5622
AD  - Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang 
      University Hospital, Seoul, Korea.
FAU - Lee, Jeongho
AU  - Lee J
AUID- ORCID: 0000-0003-4455-7540
AD  - Department of Pediatrics, Soonchunhyang University Hospital, Seoul, Korea.
FAU - Pyun, Bok Yang
AU  - Pyun BY
AUID- ORCID: 0000-0002-6375-9394
AD  - Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang 
      University Hospital, Seoul, Korea.
FAU - Jeon, You Hoon
AU  - Jeon YH
AUID- ORCID: 0000-0002-8164-7580
AD  - Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, 
      Hwaseong, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190102
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Actinidia/immunology
MH  - Adolescent
MH  - Ambrosia/immunology
MH  - Area Under Curve
MH  - Betula/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/complications/*diagnosis
MH  - Female
MH  - Food Hypersensitivity/complications/*diagnosis/epidemiology/prevention & control
MH  - Humans
MH  - Immunoglobulin E/blood/metabolism
MH  - Male
MH  - Malus/immunology
MH  - Pollen/immunology
MH  - Prevalence
MH  - ROC Curve
MH  - Republic of Korea/epidemiology
PMC - PMC6327088
OTO - NOTNLM
OT  - Atopic Dermatitis
OT  - Birch
OT  - Children
OT  - Oral Allergy Syndrome
COIS- Disclosure: The authors have no potential conflicts of interest to disclose.
EDAT- 2019/01/15 06:00
MHDA- 2019/04/20 06:00
PMCR- 2019/01/14
CRDT- 2019/01/15 06:00
PHST- 2018/08/06 00:00 [received]
PHST- 2018/10/17 00:00 [accepted]
PHST- 2019/01/15 06:00 [entrez]
PHST- 2019/01/15 06:00 [pubmed]
PHST- 2019/04/20 06:00 [medline]
PHST- 2019/01/14 00:00 [pmc-release]
AID - 10.3346/jkms.2019.34.e11 [doi]
PST - epublish
SO  - J Korean Med Sci. 2019 Jan 2;34(2):e11. doi: 10.3346/jkms.2019.34.e11. 
      eCollection 2019 Jan 14.